Dermoscopic appearance of an amelanotic mucosal melanoma

Background: Hypomelanotic or amelanotic melanomas are challenging to identify, especially at mucosal sites. The dermoscopic clues to the diagnosis of mucosal melanomas have been reported to be structureless zones with the presence of blue, gray, or white colors. Case: A female in her seventies n...

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Autores principales:	Andreas Blum, Ulrike Beck-Zoul, Laura Held, Sylvie Haase
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2016
Materias:	melanoma mucosal melanoma dermoscopy Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/9f9703e941e84e529019f715c59ffa1f
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spelling	oai:doaj.org-article:9f9703e941e84e529019f715c59ffa1f2021-11-17T08:30:59ZDermoscopic appearance of an amelanotic mucosal melanoma10.5826/dpc.0604a052160-9381https://doaj.org/article/9f9703e941e84e529019f715c59ffa1f2016-10-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/183https://doaj.org/toc/2160-9381 Background: Hypomelanotic or amelanotic melanomas are challenging to identify, especially at mucosal sites. The dermoscopic clues to the diagnosis of mucosal melanomas have been reported to be structureless zones with the presence of blue, gray, or white colors. Case: A female in her seventies noted a new lesion on the inside of her right labia that first appeared two months prior. Her past medical history was significant for rheumatoid arthritis requiring ongoing treatment with methotrexate for 20 years and adalimumab for 10 years. After no response to two weeks of local treatment for suspected herpes simplex infection, her gynecologist performed a skin biopsy. Based on the histopathological diagnosis of an amelanotic melanoma (Breslow thickness of 1.3 mm) the patient was referred to dermatology for further assessment. Polarized dermoscopy revealed a distinct asymmetric, sharply demarcated homogenous white papule (4 x 5 mm) as well as polymorphous vessels. Conclusion: Dermoscopy may aid in the diagnosis of amelanotic mucosal melanomas. Our case revealed a structureless white area and polymorphous vessels. Additional clues to the diagnosis were the advanced age of the patient and the clinical presentation of a new lesion. Andreas BlumUlrike Beck-ZoulLaura HeldSylvie HaaseMattioli1885articlemelanomamucosal melanomadermoscopyDermatologyRL1-803ENDermatology Practical & Conceptual (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	melanoma mucosal melanoma dermoscopy Dermatology RL1-803
spellingShingle	melanoma mucosal melanoma dermoscopy Dermatology RL1-803 Andreas Blum Ulrike Beck-Zoul Laura Held Sylvie Haase Dermoscopic appearance of an amelanotic mucosal melanoma
description	Background: Hypomelanotic or amelanotic melanomas are challenging to identify, especially at mucosal sites. The dermoscopic clues to the diagnosis of mucosal melanomas have been reported to be structureless zones with the presence of blue, gray, or white colors. Case: A female in her seventies noted a new lesion on the inside of her right labia that first appeared two months prior. Her past medical history was significant for rheumatoid arthritis requiring ongoing treatment with methotrexate for 20 years and adalimumab for 10 years. After no response to two weeks of local treatment for suspected herpes simplex infection, her gynecologist performed a skin biopsy. Based on the histopathological diagnosis of an amelanotic melanoma (Breslow thickness of 1.3 mm) the patient was referred to dermatology for further assessment. Polarized dermoscopy revealed a distinct asymmetric, sharply demarcated homogenous white papule (4 x 5 mm) as well as polymorphous vessels. Conclusion: Dermoscopy may aid in the diagnosis of amelanotic mucosal melanomas. Our case revealed a structureless white area and polymorphous vessels. Additional clues to the diagnosis were the advanced age of the patient and the clinical presentation of a new lesion.
format	article
author	Andreas Blum Ulrike Beck-Zoul Laura Held Sylvie Haase
author_facet	Andreas Blum Ulrike Beck-Zoul Laura Held Sylvie Haase
author_sort	Andreas Blum
title	Dermoscopic appearance of an amelanotic mucosal melanoma
title_short	Dermoscopic appearance of an amelanotic mucosal melanoma
title_full	Dermoscopic appearance of an amelanotic mucosal melanoma
title_fullStr	Dermoscopic appearance of an amelanotic mucosal melanoma
title_full_unstemmed	Dermoscopic appearance of an amelanotic mucosal melanoma
title_sort	dermoscopic appearance of an amelanotic mucosal melanoma
publisher	Mattioli1885
publishDate	2016
url	https://doaj.org/article/9f9703e941e84e529019f715c59ffa1f
work_keys_str_mv	AT andreasblum dermoscopicappearanceofanamelanoticmucosalmelanoma AT ulrikebeckzoul dermoscopicappearanceofanamelanoticmucosalmelanoma AT lauraheld dermoscopicappearanceofanamelanoticmucosalmelanoma AT sylviehaase dermoscopicappearanceofanamelanoticmucosalmelanoma
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Dermoscopic appearance of an amelanotic mucosal melanoma

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