Access to enantioenriched compounds bearing challenging tetrasubstituted stereocenters via kinetic resolution of auxiliary adjacent alcohols

A large number of enantiopure substances, such as those with tetrasubstituted carbon centres bearing several similar substituents, are inaccessible due to the incapability of chiral catalysts/ligands to recognize those substrates. Here, the authors develop kinetic resolution of auxiliary adjacent al...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shengtong Niu, Hao Zhang, Weici Xu, Prasanta Ray Bagdi, Guoxiang Zhang, Jinggong Liu, Shuang Yang, Xinqiang Fang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9f992a20413744d4a39aebedfbf97e4e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9f992a20413744d4a39aebedfbf97e4e
record_format	dspace
spelling	oai:doaj.org-article:9f992a20413744d4a39aebedfbf97e4e2021-12-02T17:40:24ZAccess to enantioenriched compounds bearing challenging tetrasubstituted stereocenters via kinetic resolution of auxiliary adjacent alcohols10.1038/s41467-021-23990-42041-1723https://doaj.org/article/9f992a20413744d4a39aebedfbf97e4e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23990-4https://doaj.org/toc/2041-1723A large number of enantiopure substances, such as those with tetrasubstituted carbon centres bearing several similar substituents, are inaccessible due to the incapability of chiral catalysts/ligands to recognize those substrates. Here, the authors develop kinetic resolution of auxiliary adjacent alcohols (KRA*) strategy to access various optically enriched compounds with two, three or four spatially and electronically similar groups.Shengtong NiuHao ZhangWeici XuPrasanta Ray BagdiGuoxiang ZhangJinggong LiuShuang YangXinqiang FangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shengtong Niu Hao Zhang Weici Xu Prasanta Ray Bagdi Guoxiang Zhang Jinggong Liu Shuang Yang Xinqiang Fang Access to enantioenriched compounds bearing challenging tetrasubstituted stereocenters via kinetic resolution of auxiliary adjacent alcohols
description	A large number of enantiopure substances, such as those with tetrasubstituted carbon centres bearing several similar substituents, are inaccessible due to the incapability of chiral catalysts/ligands to recognize those substrates. Here, the authors develop kinetic resolution of auxiliary adjacent alcohols (KRA*) strategy to access various optically enriched compounds with two, three or four spatially and electronically similar groups.
format	article
author	Shengtong Niu Hao Zhang Weici Xu Prasanta Ray Bagdi Guoxiang Zhang Jinggong Liu Shuang Yang Xinqiang Fang
author_facet	Shengtong Niu Hao Zhang Weici Xu Prasanta Ray Bagdi Guoxiang Zhang Jinggong Liu Shuang Yang Xinqiang Fang
author_sort	Shengtong Niu
title	Access to enantioenriched compounds bearing challenging tetrasubstituted stereocenters via kinetic resolution of auxiliary adjacent alcohols
title_short	Access to enantioenriched compounds bearing challenging tetrasubstituted stereocenters via kinetic resolution of auxiliary adjacent alcohols
title_full	Access to enantioenriched compounds bearing challenging tetrasubstituted stereocenters via kinetic resolution of auxiliary adjacent alcohols
title_fullStr	Access to enantioenriched compounds bearing challenging tetrasubstituted stereocenters via kinetic resolution of auxiliary adjacent alcohols
title_full_unstemmed	Access to enantioenriched compounds bearing challenging tetrasubstituted stereocenters via kinetic resolution of auxiliary adjacent alcohols
title_sort	access to enantioenriched compounds bearing challenging tetrasubstituted stereocenters via kinetic resolution of auxiliary adjacent alcohols
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9f992a20413744d4a39aebedfbf97e4e
work_keys_str_mv	AT shengtongniu accesstoenantioenrichedcompoundsbearingchallengingtetrasubstitutedstereocentersviakineticresolutionofauxiliaryadjacentalcohols AT haozhang accesstoenantioenrichedcompoundsbearingchallengingtetrasubstitutedstereocentersviakineticresolutionofauxiliaryadjacentalcohols AT weicixu accesstoenantioenrichedcompoundsbearingchallengingtetrasubstitutedstereocentersviakineticresolutionofauxiliaryadjacentalcohols AT prasantaraybagdi accesstoenantioenrichedcompoundsbearingchallengingtetrasubstitutedstereocentersviakineticresolutionofauxiliaryadjacentalcohols AT guoxiangzhang accesstoenantioenrichedcompoundsbearingchallengingtetrasubstitutedstereocentersviakineticresolutionofauxiliaryadjacentalcohols AT jinggongliu accesstoenantioenrichedcompoundsbearingchallengingtetrasubstitutedstereocentersviakineticresolutionofauxiliaryadjacentalcohols AT shuangyang accesstoenantioenrichedcompoundsbearingchallengingtetrasubstitutedstereocentersviakineticresolutionofauxiliaryadjacentalcohols AT xinqiangfang accesstoenantioenrichedcompoundsbearingchallengingtetrasubstitutedstereocentersviakineticresolutionofauxiliaryadjacentalcohols
_version_	1718379779451781120

Access to enantioenriched compounds bearing challenging tetrasubstituted stereocenters via kinetic resolution of auxiliary adjacent alcohols

Ejemplares similares