Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells

The tumour microenvironment provides signals to support leukaemic stem cells (LSC) maintenance and chemoresistance. Here, the authors show that disrupting niche-associated signalling by inhibiting receptor-mediated endocytosis with a dynamin GTPase inhibitor overcomes chemoresistance of LSC.

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Autores principales:	Cedric S. Tremblay, Sung Kai Chiu, Jesslyn Saw, Hannah McCalmont, Veronique Litalien, Jacqueline Boyle, Stefan E. Sonderegger, Ngoc Chau, Kathryn Evans, Loretta Cerruti, Jessica M. Salmon, Adam McCluskey, Richard B. Lock, Phillip J. Robinson, Stephen M. Jane, David J. Curtis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9f9ae7f5fae34540a33d8cb9dbda1467
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spelling	oai:doaj.org-article:9f9ae7f5fae34540a33d8cb9dbda14672021-12-02T15:39:16ZSmall molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells10.1038/s41467-020-20091-62041-1723https://doaj.org/article/9f9ae7f5fae34540a33d8cb9dbda14672020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20091-6https://doaj.org/toc/2041-1723The tumour microenvironment provides signals to support leukaemic stem cells (LSC) maintenance and chemoresistance. Here, the authors show that disrupting niche-associated signalling by inhibiting receptor-mediated endocytosis with a dynamin GTPase inhibitor overcomes chemoresistance of LSC.Cedric S. TremblaySung Kai ChiuJesslyn SawHannah McCalmontVeronique LitalienJacqueline BoyleStefan E. SondereggerNgoc ChauKathryn EvansLoretta CerrutiJessica M. SalmonAdam McCluskeyRichard B. LockPhillip J. RobinsonStephen M. JaneDavid J. CurtisNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cedric S. Tremblay Sung Kai Chiu Jesslyn Saw Hannah McCalmont Veronique Litalien Jacqueline Boyle Stefan E. Sonderegger Ngoc Chau Kathryn Evans Loretta Cerruti Jessica M. Salmon Adam McCluskey Richard B. Lock Phillip J. Robinson Stephen M. Jane David J. Curtis Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells
description	The tumour microenvironment provides signals to support leukaemic stem cells (LSC) maintenance and chemoresistance. Here, the authors show that disrupting niche-associated signalling by inhibiting receptor-mediated endocytosis with a dynamin GTPase inhibitor overcomes chemoresistance of LSC.
format	article
author	Cedric S. Tremblay Sung Kai Chiu Jesslyn Saw Hannah McCalmont Veronique Litalien Jacqueline Boyle Stefan E. Sonderegger Ngoc Chau Kathryn Evans Loretta Cerruti Jessica M. Salmon Adam McCluskey Richard B. Lock Phillip J. Robinson Stephen M. Jane David J. Curtis
author_facet	Cedric S. Tremblay Sung Kai Chiu Jesslyn Saw Hannah McCalmont Veronique Litalien Jacqueline Boyle Stefan E. Sonderegger Ngoc Chau Kathryn Evans Loretta Cerruti Jessica M. Salmon Adam McCluskey Richard B. Lock Phillip J. Robinson Stephen M. Jane David J. Curtis
author_sort	Cedric S. Tremblay
title	Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells
title_short	Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells
title_full	Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells
title_fullStr	Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells
title_full_unstemmed	Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells
title_sort	small molecule inhibition of dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9f9ae7f5fae34540a33d8cb9dbda1467
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Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells

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