Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis.

Detrimental inflammation of the lungs is a hallmark of severe influenza virus infections. Endothelial cells are the source of cytokine amplification, although mechanisms underlying this process are unknown. Here, using combined pharmacological and gene-deletion approaches, we show that plasminogen c...

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Autores principales:	Fatma Berri, Guus F Rimmelzwaan, Michel Hanss, Emmanuel Albina, Marie-Laure Foucault-Grunenwald, Vuong B Lê, Stella E Vogelzang-van Trierum, Patrica Gil, Eric Camerer, Dominique Martinez, Bruno Lina, Roger Lijnen, Peter Carmeliet, Béatrice Riteau
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9f9c69898aa84d7dba0eade89776cc72
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spelling	oai:doaj.org-article:9f9c69898aa84d7dba0eade89776cc722021-11-18T06:05:54ZPlasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis.1553-73661553-737410.1371/journal.ppat.1003229https://doaj.org/article/9f9c69898aa84d7dba0eade89776cc722013-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23555246/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Detrimental inflammation of the lungs is a hallmark of severe influenza virus infections. Endothelial cells are the source of cytokine amplification, although mechanisms underlying this process are unknown. Here, using combined pharmacological and gene-deletion approaches, we show that plasminogen controls lung inflammation and pathogenesis of infections with influenza A/PR/8/34, highly pathogenic H5N1 and 2009 pandemic H1N1 viruses. Reduction of virus replication was not responsible for the observed effect. However, pharmacological depletion of fibrinogen, the main target of plasminogen reversed disease resistance of plasminogen-deficient mice or mice treated with an inhibitor of plasminogen-mediated fibrinolysis. Therefore, plasminogen contributes to the deleterious inflammation of the lungs and local fibrin clot formation may be implicated in host defense against influenza virus infections. Our studies suggest that the hemostatic system might be explored for novel treatments against influenza.Fatma BerriGuus F RimmelzwaanMichel HanssEmmanuel AlbinaMarie-Laure Foucault-GrunenwaldVuong B LêStella E Vogelzang-van TrierumPatrica GilEric CamererDominique MartinezBruno LinaRoger LijnenPeter CarmelietBéatrice RiteauPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 9, Iss 3, p e1003229 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Fatma Berri Guus F Rimmelzwaan Michel Hanss Emmanuel Albina Marie-Laure Foucault-Grunenwald Vuong B Lê Stella E Vogelzang-van Trierum Patrica Gil Eric Camerer Dominique Martinez Bruno Lina Roger Lijnen Peter Carmeliet Béatrice Riteau Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis.
description	Detrimental inflammation of the lungs is a hallmark of severe influenza virus infections. Endothelial cells are the source of cytokine amplification, although mechanisms underlying this process are unknown. Here, using combined pharmacological and gene-deletion approaches, we show that plasminogen controls lung inflammation and pathogenesis of infections with influenza A/PR/8/34, highly pathogenic H5N1 and 2009 pandemic H1N1 viruses. Reduction of virus replication was not responsible for the observed effect. However, pharmacological depletion of fibrinogen, the main target of plasminogen reversed disease resistance of plasminogen-deficient mice or mice treated with an inhibitor of plasminogen-mediated fibrinolysis. Therefore, plasminogen contributes to the deleterious inflammation of the lungs and local fibrin clot formation may be implicated in host defense against influenza virus infections. Our studies suggest that the hemostatic system might be explored for novel treatments against influenza.
format	article
author	Fatma Berri Guus F Rimmelzwaan Michel Hanss Emmanuel Albina Marie-Laure Foucault-Grunenwald Vuong B Lê Stella E Vogelzang-van Trierum Patrica Gil Eric Camerer Dominique Martinez Bruno Lina Roger Lijnen Peter Carmeliet Béatrice Riteau
author_facet	Fatma Berri Guus F Rimmelzwaan Michel Hanss Emmanuel Albina Marie-Laure Foucault-Grunenwald Vuong B Lê Stella E Vogelzang-van Trierum Patrica Gil Eric Camerer Dominique Martinez Bruno Lina Roger Lijnen Peter Carmeliet Béatrice Riteau
author_sort	Fatma Berri
title	Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis.
title_short	Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis.
title_full	Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis.
title_fullStr	Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis.
title_full_unstemmed	Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis.
title_sort	plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/9f9c69898aa84d7dba0eade89776cc72
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Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis.

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