Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis.

Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis.

Detrimental inflammation of the lungs is a hallmark of severe influenza virus infections. Endothelial cells are the source of cytokine amplification, although mechanisms underlying this process are unknown. Here, using combined pharmacological and gene-deletion approaches, we show that plasminogen c...

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Auteurs principaux: Fatma Berri, Guus F Rimmelzwaan, Michel Hanss, Emmanuel Albina, Marie-Laure Foucault-Grunenwald, Vuong B Lê, Stella E Vogelzang-van Trierum, Patrica Gil, Eric Camerer, Dominique Martinez, Bruno Lina, Roger Lijnen, Peter Carmeliet, Béatrice Riteau
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2013
Sujets:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Accès en ligne:https://doaj.org/article/9f9c69898aa84d7dba0eade89776cc72
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Internet

https://doaj.org/article/9f9c69898aa84d7dba0eade89776cc72

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