Coordinated activation of distinct Ca2+ sources and metabotropic glutamate receptors encodes Hebbian synaptic plasticity

During STDP, the magnitude of postsynaptic Ca2+transients is hypothesized to determine the strength of synaptic plasticity. Here, the authors find that STDP in mature hippocampal synapses does not obey this rule but instead relies on the coordinated activation of NMDARs and VGCCs and their regulatio...

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Autores principales:	Cezar M. Tigaret, Valeria Olivo, Josef H.L.P. Sadowski, Michael C. Ashby, Jack R. Mellor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9f9d787105724ad4af6f572861d5bab0
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spelling	oai:doaj.org-article:9f9d787105724ad4af6f572861d5bab02021-12-02T17:31:51ZCoordinated activation of distinct Ca2+ sources and metabotropic glutamate receptors encodes Hebbian synaptic plasticity10.1038/ncomms102892041-1723https://doaj.org/article/9f9d787105724ad4af6f572861d5bab02016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10289https://doaj.org/toc/2041-1723During STDP, the magnitude of postsynaptic Ca2+transients is hypothesized to determine the strength of synaptic plasticity. Here, the authors find that STDP in mature hippocampal synapses does not obey this rule but instead relies on the coordinated activation of NMDARs and VGCCs and their regulation by mGluRs and SK channels.Cezar M. TigaretValeria OlivoJosef H.L.P. SadowskiMichael C. AshbyJack R. MellorNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cezar M. Tigaret Valeria Olivo Josef H.L.P. Sadowski Michael C. Ashby Jack R. Mellor Coordinated activation of distinct Ca2+ sources and metabotropic glutamate receptors encodes Hebbian synaptic plasticity
description	During STDP, the magnitude of postsynaptic Ca2+transients is hypothesized to determine the strength of synaptic plasticity. Here, the authors find that STDP in mature hippocampal synapses does not obey this rule but instead relies on the coordinated activation of NMDARs and VGCCs and their regulation by mGluRs and SK channels.
format	article
author	Cezar M. Tigaret Valeria Olivo Josef H.L.P. Sadowski Michael C. Ashby Jack R. Mellor
author_facet	Cezar M. Tigaret Valeria Olivo Josef H.L.P. Sadowski Michael C. Ashby Jack R. Mellor
author_sort	Cezar M. Tigaret
title	Coordinated activation of distinct Ca2+ sources and metabotropic glutamate receptors encodes Hebbian synaptic plasticity
title_short	Coordinated activation of distinct Ca2+ sources and metabotropic glutamate receptors encodes Hebbian synaptic plasticity
title_full	Coordinated activation of distinct Ca2+ sources and metabotropic glutamate receptors encodes Hebbian synaptic plasticity
title_fullStr	Coordinated activation of distinct Ca2+ sources and metabotropic glutamate receptors encodes Hebbian synaptic plasticity
title_full_unstemmed	Coordinated activation of distinct Ca2+ sources and metabotropic glutamate receptors encodes Hebbian synaptic plasticity
title_sort	coordinated activation of distinct ca2+ sources and metabotropic glutamate receptors encodes hebbian synaptic plasticity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/9f9d787105724ad4af6f572861d5bab0
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Coordinated activation of distinct Ca2+ sources and metabotropic glutamate receptors encodes Hebbian synaptic plasticity

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