Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition

Transcription activator-like effector proteins recognise specific DNA sequences via tandem repeats. Here the authors demonstrate TALEs can recognise the methylated bases 5mC and 5hmC, enabling them to detect epigenetic modifications.

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Autores principales:	Yuan Zhang, Lulu Liu, Shengjie Guo, Jinghui Song, Chenxu Zhu, Zongwei Yue, Wensheng Wei, Chengqi Yi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9fa1a1debc864944b0f358f9a944cd6f
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spelling	oai:doaj.org-article:9fa1a1debc864944b0f358f9a944cd6f2021-12-02T15:38:47ZDeciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition10.1038/s41467-017-00860-62041-1723https://doaj.org/article/9fa1a1debc864944b0f358f9a944cd6f2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00860-6https://doaj.org/toc/2041-1723Transcription activator-like effector proteins recognise specific DNA sequences via tandem repeats. Here the authors demonstrate TALEs can recognise the methylated bases 5mC and 5hmC, enabling them to detect epigenetic modifications.Yuan ZhangLulu LiuShengjie GuoJinghui SongChenxu ZhuZongwei YueWensheng WeiChengqi YiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuan Zhang Lulu Liu Shengjie Guo Jinghui Song Chenxu Zhu Zongwei Yue Wensheng Wei Chengqi Yi Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition
description	Transcription activator-like effector proteins recognise specific DNA sequences via tandem repeats. Here the authors demonstrate TALEs can recognise the methylated bases 5mC and 5hmC, enabling them to detect epigenetic modifications.
format	article
author	Yuan Zhang Lulu Liu Shengjie Guo Jinghui Song Chenxu Zhu Zongwei Yue Wensheng Wei Chengqi Yi
author_facet	Yuan Zhang Lulu Liu Shengjie Guo Jinghui Song Chenxu Zhu Zongwei Yue Wensheng Wei Chengqi Yi
author_sort	Yuan Zhang
title	Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition
title_short	Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition
title_full	Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition
title_fullStr	Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition
title_full_unstemmed	Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition
title_sort	deciphering tal effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9fa1a1debc864944b0f358f9a944cd6f
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Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition

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