Role of circulating angiogenin levels in portal hypertension and TIPS.

<h4>Background</h4>Pathogenesis of portal hypertension is multifactorial and includes pathologic intrahepatic angiogenesis, whereby TIPS insertion is an effective therapy of portal hypertension associated complications. While angiogenin is a potent contributor to angiogenesis in general,...

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Autores principales:	Alexander Queck, Frank E Uschner, Philip G Ferstl, Martin Schulz, Maximilian J Brol, Michael Praktiknjo, Robert Schierwagen, Sabine Klein, Christian P Strassburg, Carsten Meyer, Christian Jansen, Marie-Luise Berres, Jonel Trebicka
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9fa2a0477e6649d599c9a9453526128a
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spelling	oai:doaj.org-article:9fa2a0477e6649d599c9a9453526128a2021-12-02T20:19:33ZRole of circulating angiogenin levels in portal hypertension and TIPS.1932-620310.1371/journal.pone.0256473https://doaj.org/article/9fa2a0477e6649d599c9a9453526128a2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256473https://doaj.org/toc/1932-6203<h4>Background</h4>Pathogenesis of portal hypertension is multifactorial and includes pathologic intrahepatic angiogenesis, whereby TIPS insertion is an effective therapy of portal hypertension associated complications. While angiogenin is a potent contributor to angiogenesis in general, little is known about its impact on TIPS function over time.<h4>Methods</h4>In a total of 118 samples from 47 patients, angiogenin concentrations were measured in portal and inferior caval vein plasma at TIPS insertion (each blood compartment n = 23) or angiographic intervention after TIPS (each blood compartment n = 36) and its relationship with patient outcome was investigated.<h4>Results</h4>Angiogenin levels in the inferior caval vein were significantly higher compared to the portal vein (P = 0.048). Ten to 14 days after TIPS, inferior caval vein angiogenin level correlated inversely with the portal systemic pressure gradient (P<0.001), measured invasively during control angiography. Moreover, patients with TIPS revision during this angiography, showed significantly lower angiogenin level in the inferior caval vein compared to patients without TIPS dysfunction (P = 0.01).<h4>Conclusion</h4>In cirrhosis patients with complications of severe portal hypertension, circulating levels of angiogenin are derived from the injured liver. Moreover, angiogenin levels in the inferior caval vein after TIPS may predict TIPS dysfunction.Alexander QueckFrank E UschnerPhilip G FerstlMartin SchulzMaximilian J BrolMichael PraktiknjoRobert SchierwagenSabine KleinChristian P StrassburgCarsten MeyerChristian JansenMarie-Luise BerresJonel TrebickaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256473 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alexander Queck Frank E Uschner Philip G Ferstl Martin Schulz Maximilian J Brol Michael Praktiknjo Robert Schierwagen Sabine Klein Christian P Strassburg Carsten Meyer Christian Jansen Marie-Luise Berres Jonel Trebicka Role of circulating angiogenin levels in portal hypertension and TIPS.
description	<h4>Background</h4>Pathogenesis of portal hypertension is multifactorial and includes pathologic intrahepatic angiogenesis, whereby TIPS insertion is an effective therapy of portal hypertension associated complications. While angiogenin is a potent contributor to angiogenesis in general, little is known about its impact on TIPS function over time.<h4>Methods</h4>In a total of 118 samples from 47 patients, angiogenin concentrations were measured in portal and inferior caval vein plasma at TIPS insertion (each blood compartment n = 23) or angiographic intervention after TIPS (each blood compartment n = 36) and its relationship with patient outcome was investigated.<h4>Results</h4>Angiogenin levels in the inferior caval vein were significantly higher compared to the portal vein (P = 0.048). Ten to 14 days after TIPS, inferior caval vein angiogenin level correlated inversely with the portal systemic pressure gradient (P<0.001), measured invasively during control angiography. Moreover, patients with TIPS revision during this angiography, showed significantly lower angiogenin level in the inferior caval vein compared to patients without TIPS dysfunction (P = 0.01).<h4>Conclusion</h4>In cirrhosis patients with complications of severe portal hypertension, circulating levels of angiogenin are derived from the injured liver. Moreover, angiogenin levels in the inferior caval vein after TIPS may predict TIPS dysfunction.
format	article
author	Alexander Queck Frank E Uschner Philip G Ferstl Martin Schulz Maximilian J Brol Michael Praktiknjo Robert Schierwagen Sabine Klein Christian P Strassburg Carsten Meyer Christian Jansen Marie-Luise Berres Jonel Trebicka
author_facet	Alexander Queck Frank E Uschner Philip G Ferstl Martin Schulz Maximilian J Brol Michael Praktiknjo Robert Schierwagen Sabine Klein Christian P Strassburg Carsten Meyer Christian Jansen Marie-Luise Berres Jonel Trebicka
author_sort	Alexander Queck
title	Role of circulating angiogenin levels in portal hypertension and TIPS.
title_short	Role of circulating angiogenin levels in portal hypertension and TIPS.
title_full	Role of circulating angiogenin levels in portal hypertension and TIPS.
title_fullStr	Role of circulating angiogenin levels in portal hypertension and TIPS.
title_full_unstemmed	Role of circulating angiogenin levels in portal hypertension and TIPS.
title_sort	role of circulating angiogenin levels in portal hypertension and tips.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/9fa2a0477e6649d599c9a9453526128a
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Role of circulating angiogenin levels in portal hypertension and TIPS.

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