Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1

Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1

Narcolepsy type 1 (NT1) is a severe sleep disorder with strong association to the HLA type DQB1*0602 and increased incidence among children vaccinated with the Influenza A vaccine Pandemrix. Here the authors show that these children develop T and B cell autoimmunity against protein-O-mannosyltransfe...

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Autores principales: A. Vuorela, T. L. Freitag, K. Leskinen, H. Pessa, T. Härkönen, I. Stracenski, T. Kirjavainen, P. Olsen, O. Saarenpää-Heikkilä, J. Ilonen, M. Knip, A. Vaheri, M. Partinen, P. Saavalainen, S. Meri, O. Vaarala
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/9fa5bcd4c4734421be40062b8170747a
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spelling oai:doaj.org-article:9fa5bcd4c4734421be40062b8170747a2021-12-02T14:25:16ZEnhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 110.1038/s41467-021-22637-82041-1723https://doaj.org/article/9fa5bcd4c4734421be40062b8170747a2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22637-8https://doaj.org/toc/2041-1723Narcolepsy type 1 (NT1) is a severe sleep disorder with strong association to the HLA type DQB1*0602 and increased incidence among children vaccinated with the Influenza A vaccine Pandemrix. Here the authors show that these children develop T and B cell autoimmunity against protein-O-mannosyltransferase 1 via cross-reactivity.A. VuorelaT. L. FreitagK. LeskinenH. PessaT. HärkönenI. StracenskiT. KirjavainenP. OlsenO. Saarenpää-HeikkiläJ. IlonenM. KnipA. VaheriM. PartinenP. SaavalainenS. MeriO. VaaralaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
A. Vuorela
T. L. Freitag
K. Leskinen
H. Pessa
T. Härkönen
I. Stracenski
T. Kirjavainen
P. Olsen
O. Saarenpää-Heikkilä
J. Ilonen
M. Knip
A. Vaheri
M. Partinen
P. Saavalainen
S. Meri
O. Vaarala
Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1
description Narcolepsy type 1 (NT1) is a severe sleep disorder with strong association to the HLA type DQB1*0602 and increased incidence among children vaccinated with the Influenza A vaccine Pandemrix. Here the authors show that these children develop T and B cell autoimmunity against protein-O-mannosyltransferase 1 via cross-reactivity.
format article
author A. Vuorela
T. L. Freitag
K. Leskinen
H. Pessa
T. Härkönen
I. Stracenski
T. Kirjavainen
P. Olsen
O. Saarenpää-Heikkilä
J. Ilonen
M. Knip
A. Vaheri
M. Partinen
P. Saavalainen
S. Meri
O. Vaarala
author_facet A. Vuorela
T. L. Freitag
K. Leskinen
H. Pessa
T. Härkönen
I. Stracenski
T. Kirjavainen
P. Olsen
O. Saarenpää-Heikkilä
J. Ilonen
M. Knip
A. Vaheri
M. Partinen
P. Saavalainen
S. Meri
O. Vaarala
author_sort A. Vuorela
title Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1
title_short Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1
title_full Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1
title_fullStr Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1
title_full_unstemmed Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1
title_sort enhanced influenza a h1n1 t cell epitope recognition and cross-reactivity to protein-o-mannosyltransferase 1 in pandemrix-associated narcolepsy type 1
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/9fa5bcd4c4734421be40062b8170747a
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