Silencing of LINC00707 suppresses cell proliferation, migration, and invasion of osteosarcoma cells by modulating miR-338-3p/AHSA1 axis

Osteosarcoma is the most common type of primary malignant tumor of the bone, with a high metastatic rate and poor prognosis. Therefore, it is important to further elucidate the molecular mechanisms involved in the development of osteosarcoma and explore new molecular therapeutic targets. Long interg...

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Autores principales:	Zhang Xiao-rong, Shao Jian-li, Li Heng, Wang Liang
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	linc00707 osteosarcoma cerna mir-338-3p ahsa1 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9fa619a8a1b0496da13efb5f1d6ad8a7
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spelling	oai:doaj.org-article:9fa619a8a1b0496da13efb5f1d6ad8a72021-12-05T14:10:41ZSilencing of LINC00707 suppresses cell proliferation, migration, and invasion of osteosarcoma cells by modulating miR-338-3p/AHSA1 axis2391-541210.1515/biol-2021-0070https://doaj.org/article/9fa619a8a1b0496da13efb5f1d6ad8a72021-07-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0070https://doaj.org/toc/2391-5412Osteosarcoma is the most common type of primary malignant tumor of the bone, with a high metastatic rate and poor prognosis. Therefore, it is important to further elucidate the molecular mechanisms involved in the development of osteosarcoma and explore new molecular therapeutic targets. Long intergenic nonprotein-coding RNA 707 (LINC00707) is an oncogenic gene in several cancers. In this study, we further clarified its role and regulatory mechanism in osteosarcoma. We found that LINC00707 levels are significantly higher in the osteosarcoma cell lines SW 1353, HOS, U-2 OS, MG-63, and Saos-2 compared to those in human fetal osteoblastic cell line hFOB1.19. LINC00707 silencing suppressed cell proliferation, migration, and invasion of MG-63 and Saos-2 cells. Moreover, LINC00707 can act as a competitive endogenous RNA of miR-338-3p, and miR-338-3p inhibitor and AHSA1 overexpression alleviated the effect of LINC00707 silencing. In conclusion, we demonstrated high expression of LINC00707 in osteosarcoma cell lines and that silencing LINC00707 suppresses cell proliferation, migration, and invasion by targeting the miR-338-3p/AHSA1 axis in MG-63 and Saos-2 cells. These findings suggest that LINC00707 may serve as a potential target for osteosarcoma treatment.Zhang Xiao-rongShao Jian-liLi HengWang LiangDe Gruyterarticlelinc00707osteosarcomacernamir-338-3pahsa1Biology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 728-736 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	linc00707 osteosarcoma cerna mir-338-3p ahsa1 Biology (General) QH301-705.5
spellingShingle	linc00707 osteosarcoma cerna mir-338-3p ahsa1 Biology (General) QH301-705.5 Zhang Xiao-rong Shao Jian-li Li Heng Wang Liang Silencing of LINC00707 suppresses cell proliferation, migration, and invasion of osteosarcoma cells by modulating miR-338-3p/AHSA1 axis
description	Osteosarcoma is the most common type of primary malignant tumor of the bone, with a high metastatic rate and poor prognosis. Therefore, it is important to further elucidate the molecular mechanisms involved in the development of osteosarcoma and explore new molecular therapeutic targets. Long intergenic nonprotein-coding RNA 707 (LINC00707) is an oncogenic gene in several cancers. In this study, we further clarified its role and regulatory mechanism in osteosarcoma. We found that LINC00707 levels are significantly higher in the osteosarcoma cell lines SW 1353, HOS, U-2 OS, MG-63, and Saos-2 compared to those in human fetal osteoblastic cell line hFOB1.19. LINC00707 silencing suppressed cell proliferation, migration, and invasion of MG-63 and Saos-2 cells. Moreover, LINC00707 can act as a competitive endogenous RNA of miR-338-3p, and miR-338-3p inhibitor and AHSA1 overexpression alleviated the effect of LINC00707 silencing. In conclusion, we demonstrated high expression of LINC00707 in osteosarcoma cell lines and that silencing LINC00707 suppresses cell proliferation, migration, and invasion by targeting the miR-338-3p/AHSA1 axis in MG-63 and Saos-2 cells. These findings suggest that LINC00707 may serve as a potential target for osteosarcoma treatment.
format	article
author	Zhang Xiao-rong Shao Jian-li Li Heng Wang Liang
author_facet	Zhang Xiao-rong Shao Jian-li Li Heng Wang Liang
author_sort	Zhang Xiao-rong
title	Silencing of LINC00707 suppresses cell proliferation, migration, and invasion of osteosarcoma cells by modulating miR-338-3p/AHSA1 axis
title_short	Silencing of LINC00707 suppresses cell proliferation, migration, and invasion of osteosarcoma cells by modulating miR-338-3p/AHSA1 axis
title_full	Silencing of LINC00707 suppresses cell proliferation, migration, and invasion of osteosarcoma cells by modulating miR-338-3p/AHSA1 axis
title_fullStr	Silencing of LINC00707 suppresses cell proliferation, migration, and invasion of osteosarcoma cells by modulating miR-338-3p/AHSA1 axis
title_full_unstemmed	Silencing of LINC00707 suppresses cell proliferation, migration, and invasion of osteosarcoma cells by modulating miR-338-3p/AHSA1 axis
title_sort	silencing of linc00707 suppresses cell proliferation, migration, and invasion of osteosarcoma cells by modulating mir-338-3p/ahsa1 axis
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/9fa619a8a1b0496da13efb5f1d6ad8a7
work_keys_str_mv	AT zhangxiaorong silencingoflinc00707suppressescellproliferationmigrationandinvasionofosteosarcomacellsbymodulatingmir3383pahsa1axis AT shaojianli silencingoflinc00707suppressescellproliferationmigrationandinvasionofosteosarcomacellsbymodulatingmir3383pahsa1axis AT liheng silencingoflinc00707suppressescellproliferationmigrationandinvasionofosteosarcomacellsbymodulatingmir3383pahsa1axis AT wangliang silencingoflinc00707suppressescellproliferationmigrationandinvasionofosteosarcomacellsbymodulatingmir3383pahsa1axis
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Silencing of LINC00707 suppresses cell proliferation, migration, and invasion of osteosarcoma cells by modulating miR-338-3p/AHSA1 axis

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