Computational analysis of candidate disease genes and variants for salt-sensitive hypertension in indigenous Southern Africans.

Multiple factors underlie susceptibility to essential hypertension, including a significant genetic and ethnic component, and environmental effects. Blood pressure response of hypertensive individuals to salt is heterogeneous, but salt sensitivity appears more prevalent in people of indigenous Afric...

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Autores principales:	Nicki Tiffin, Ayton Meintjes, Rajkumar Ramesar, Vladimir B Bajic, Brian Rayner
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9fab1f8a73584ee19c3b0616c2d9d439
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spelling	oai:doaj.org-article:9fab1f8a73584ee19c3b0616c2d9d4392021-11-18T06:34:44ZComputational analysis of candidate disease genes and variants for salt-sensitive hypertension in indigenous Southern Africans.1932-620310.1371/journal.pone.0012989https://doaj.org/article/9fab1f8a73584ee19c3b0616c2d9d4392010-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20886000/?tool=EBIhttps://doaj.org/toc/1932-6203Multiple factors underlie susceptibility to essential hypertension, including a significant genetic and ethnic component, and environmental effects. Blood pressure response of hypertensive individuals to salt is heterogeneous, but salt sensitivity appears more prevalent in people of indigenous African origin. The underlying genetics of salt-sensitive hypertension, however, are poorly understood. In this study, computational methods including text- and data-mining have been used to select and prioritize candidate aetiological genes for salt-sensitive hypertension. Additionally, we have compared allele frequencies and copy number variation for single nucleotide polymorphisms in candidate genes between indigenous Southern African and Caucasian populations, with the aim of identifying candidate genes with significant variability between the population groups: identifying genetic variability between population groups can exploit ethnic differences in disease prevalence to aid with prioritisation of good candidate genes. Our top-ranking candidate genes include parathyroid hormone precursor (PTH) and type-1 angiotensin II receptor (AGTR1). We propose that the candidate genes identified in this study warrant further investigation as potential aetiological genes for salt-sensitive hypertension.Nicki TiffinAyton MeintjesRajkumar RamesarVladimir B BajicBrian RaynerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 9, p e12989 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nicki Tiffin Ayton Meintjes Rajkumar Ramesar Vladimir B Bajic Brian Rayner Computational analysis of candidate disease genes and variants for salt-sensitive hypertension in indigenous Southern Africans.
description	Multiple factors underlie susceptibility to essential hypertension, including a significant genetic and ethnic component, and environmental effects. Blood pressure response of hypertensive individuals to salt is heterogeneous, but salt sensitivity appears more prevalent in people of indigenous African origin. The underlying genetics of salt-sensitive hypertension, however, are poorly understood. In this study, computational methods including text- and data-mining have been used to select and prioritize candidate aetiological genes for salt-sensitive hypertension. Additionally, we have compared allele frequencies and copy number variation for single nucleotide polymorphisms in candidate genes between indigenous Southern African and Caucasian populations, with the aim of identifying candidate genes with significant variability between the population groups: identifying genetic variability between population groups can exploit ethnic differences in disease prevalence to aid with prioritisation of good candidate genes. Our top-ranking candidate genes include parathyroid hormone precursor (PTH) and type-1 angiotensin II receptor (AGTR1). We propose that the candidate genes identified in this study warrant further investigation as potential aetiological genes for salt-sensitive hypertension.
format	article
author	Nicki Tiffin Ayton Meintjes Rajkumar Ramesar Vladimir B Bajic Brian Rayner
author_facet	Nicki Tiffin Ayton Meintjes Rajkumar Ramesar Vladimir B Bajic Brian Rayner
author_sort	Nicki Tiffin
title	Computational analysis of candidate disease genes and variants for salt-sensitive hypertension in indigenous Southern Africans.
title_short	Computational analysis of candidate disease genes and variants for salt-sensitive hypertension in indigenous Southern Africans.
title_full	Computational analysis of candidate disease genes and variants for salt-sensitive hypertension in indigenous Southern Africans.
title_fullStr	Computational analysis of candidate disease genes and variants for salt-sensitive hypertension in indigenous Southern Africans.
title_full_unstemmed	Computational analysis of candidate disease genes and variants for salt-sensitive hypertension in indigenous Southern Africans.
title_sort	computational analysis of candidate disease genes and variants for salt-sensitive hypertension in indigenous southern africans.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/9fab1f8a73584ee19c3b0616c2d9d439
work_keys_str_mv	AT nickitiffin computationalanalysisofcandidatediseasegenesandvariantsforsaltsensitivehypertensioninindigenoussouthernafricans AT aytonmeintjes computationalanalysisofcandidatediseasegenesandvariantsforsaltsensitivehypertensioninindigenoussouthernafricans AT rajkumarramesar computationalanalysisofcandidatediseasegenesandvariantsforsaltsensitivehypertensioninindigenoussouthernafricans AT vladimirbbajic computationalanalysisofcandidatediseasegenesandvariantsforsaltsensitivehypertensioninindigenoussouthernafricans AT brianrayner computationalanalysisofcandidatediseasegenesandvariantsforsaltsensitivehypertensioninindigenoussouthernafricans
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Computational analysis of candidate disease genes and variants for salt-sensitive hypertension in indigenous Southern Africans.

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