Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis
Tumour hypoxia influences both the immune responses and angiogenesis. Here, the authors show that HIF-1α deletion in NK cells impairs NK cytotoxic activity but inhibit tumour growth by decreasing the infiltration of NK cells that express angiostatic soluble VEGFR-1, thus resulting in non-functional...
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Nature Portfolio
2017
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oai:doaj.org-article:9fad3e202ec447b8825aaed0e43794af2021-12-02T15:37:00ZLoss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis10.1038/s41467-017-01599-w2041-1723https://doaj.org/article/9fad3e202ec447b8825aaed0e43794af2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01599-whttps://doaj.org/toc/2041-1723Tumour hypoxia influences both the immune responses and angiogenesis. Here, the authors show that HIF-1α deletion in NK cells impairs NK cytotoxic activity but inhibit tumour growth by decreasing the infiltration of NK cells that express angiostatic soluble VEGFR-1, thus resulting in non-functional angiogenesis.Ewelina KrzywinskaChahrazade Kantari-MimounYann KerdilesMichal SobeckiTakayuki IsagawaDagmar GotthardtMagali CastellsJohannes HauboldCorinne MillienThomas VielBertrand TavitianNorihiko TakedaJoachim FandreyEric VivierVeronika SexlChristian StockmannNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017) |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Ewelina Krzywinska Chahrazade Kantari-Mimoun Yann Kerdiles Michal Sobecki Takayuki Isagawa Dagmar Gotthardt Magali Castells Johannes Haubold Corinne Millien Thomas Viel Bertrand Tavitian Norihiko Takeda Joachim Fandrey Eric Vivier Veronika Sexl Christian Stockmann Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis |
| description |
Tumour hypoxia influences both the immune responses and angiogenesis. Here, the authors show that HIF-1α deletion in NK cells impairs NK cytotoxic activity but inhibit tumour growth by decreasing the infiltration of NK cells that express angiostatic soluble VEGFR-1, thus resulting in non-functional angiogenesis. |
| format |
article |
| author |
Ewelina Krzywinska Chahrazade Kantari-Mimoun Yann Kerdiles Michal Sobecki Takayuki Isagawa Dagmar Gotthardt Magali Castells Johannes Haubold Corinne Millien Thomas Viel Bertrand Tavitian Norihiko Takeda Joachim Fandrey Eric Vivier Veronika Sexl Christian Stockmann |
| author_facet |
Ewelina Krzywinska Chahrazade Kantari-Mimoun Yann Kerdiles Michal Sobecki Takayuki Isagawa Dagmar Gotthardt Magali Castells Johannes Haubold Corinne Millien Thomas Viel Bertrand Tavitian Norihiko Takeda Joachim Fandrey Eric Vivier Veronika Sexl Christian Stockmann |
| author_sort |
Ewelina Krzywinska |
| title |
Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis |
| title_short |
Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis |
| title_full |
Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis |
| title_fullStr |
Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis |
| title_full_unstemmed |
Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis |
| title_sort |
loss of hif-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/9fad3e202ec447b8825aaed0e43794af |
| work_keys_str_mv |
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1718386306415853568 |