Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation

Alzheimer's disease is linked to metabolic syndrome and Type-2 diabetes, but the mechanism behind this association is unclear. Here, the authors show that elevated glucose and amyloid ß work together to increase nitrosative stress, leading to aberrant mitochondrial activity and synaptic dysfunc...

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Autores principales:	Mohd Waseem Akhtar, Sara Sanz-Blasco, Nima Dolatabadi, James Parker, Kevin Chon, Michelle S. Lee, Walid Soussou, Scott R. McKercher, Rajesh Ambasudhan, Tomohiro Nakamura, Stuart A. Lipton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9fb0c0af61564f9ba2f975e9d457f235
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spelling	oai:doaj.org-article:9fb0c0af61564f9ba2f975e9d457f2352021-12-02T17:32:07ZElevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation10.1038/ncomms102422041-1723https://doaj.org/article/9fb0c0af61564f9ba2f975e9d457f2352016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10242https://doaj.org/toc/2041-1723Alzheimer's disease is linked to metabolic syndrome and Type-2 diabetes, but the mechanism behind this association is unclear. Here, the authors show that elevated glucose and amyloid ß work together to increase nitrosative stress, leading to aberrant mitochondrial activity and synaptic dysfunction.Mohd Waseem AkhtarSara Sanz-BlascoNima DolatabadiJames ParkerKevin ChonMichelle S. LeeWalid SoussouScott R. McKercherRajesh AmbasudhanTomohiro NakamuraStuart A. LiptonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mohd Waseem Akhtar Sara Sanz-Blasco Nima Dolatabadi James Parker Kevin Chon Michelle S. Lee Walid Soussou Scott R. McKercher Rajesh Ambasudhan Tomohiro Nakamura Stuart A. Lipton Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation
description	Alzheimer's disease is linked to metabolic syndrome and Type-2 diabetes, but the mechanism behind this association is unclear. Here, the authors show that elevated glucose and amyloid ß work together to increase nitrosative stress, leading to aberrant mitochondrial activity and synaptic dysfunction.
format	article
author	Mohd Waseem Akhtar Sara Sanz-Blasco Nima Dolatabadi James Parker Kevin Chon Michelle S. Lee Walid Soussou Scott R. McKercher Rajesh Ambasudhan Tomohiro Nakamura Stuart A. Lipton
author_facet	Mohd Waseem Akhtar Sara Sanz-Blasco Nima Dolatabadi James Parker Kevin Chon Michelle S. Lee Walid Soussou Scott R. McKercher Rajesh Ambasudhan Tomohiro Nakamura Stuart A. Lipton
author_sort	Mohd Waseem Akhtar
title	Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation
title_short	Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation
title_full	Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation
title_fullStr	Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation
title_full_unstemmed	Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation
title_sort	elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein s-nitrosylation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/9fb0c0af61564f9ba2f975e9d457f235
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Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation

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