Elevated Serum Triglycerides are Associated with Ketosis-Prone Type 2 Diabetes in Young Individuals

Shu Ye,1,* Hui Ran,1,* Hongmei Zhang,1 Hui Wu,2 Wen Li,1 Shichun Du,1 Qing Su1 1Department of Endocrinology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, People’s Republic of China; 2Department of Endocrinology, Zhejiang Provincial Peopl...

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Autores principales:	Ye S, Ran H, Zhang H, Wu H, Li W, Du S, Su Q
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	ketosis triglycerides hypertriglyceridemia Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/9fb10423193e4998b22fe9bc56af8c31
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spelling	oai:doaj.org-article:9fb10423193e4998b22fe9bc56af8c312021-12-02T14:24:11ZElevated Serum Triglycerides are Associated with Ketosis-Prone Type 2 Diabetes in Young Individuals1178-7007https://doaj.org/article/9fb10423193e4998b22fe9bc56af8c312021-02-01T00:00:00Zhttps://www.dovepress.com/elevated-serum-triglycerides-are-associated-with-ketosis-prone-type-2--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Shu Ye,1,* Hui Ran,1,* Hongmei Zhang,1 Hui Wu,2 Wen Li,1 Shichun Du,1 Qing Su1 1Department of Endocrinology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, People’s Republic of China; 2Department of Endocrinology, Zhejiang Provincial People’s Hospital, Hangzhou Medical College, Hangzhou, 310014, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shichun DuDepartment of Endocrinology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Kong Jiang Road 1665#, Shanghai, 200092, People’s Republic of ChinaEmail dushichun@xinhuamed.com.cnPurpose: Ketosis-prone type 2 diabetes (KPT2D) is increasingly recognized in young adults. However, the role of blood lipids in KPT2D, especially serum triglycerides (TGs), is not yet clearly understood.Patients and Methods: We retrospectively evaluated 409 young patients diagnosed with KPT2D or classical type 2 diabetes (T2D) attending an academic tertiary hospital. Clinical characteristics and laboratory findings were compared between KPT2D and T2D patients. ANOVA or a non-parametric test analyses were used to evaluate differences in clinical characteristics and laboratory findings. Multivariate regression analyses and stratified analyses were used to further investigate differences in serum TGs levels between KPT2D and T2D individuals.Results: KPT2D is a subtype of T2D with traits of overweight or obesity. However, hyperglycemia and impaired β-cell functions were more severe in KPT2D patients. Serum TGs levels were significantly higher (P = 0.0003) in KPT2D individuals. Furthermore, the proportion of very high serum TGs levels was 6-fold higher (P < 0.0001) in KPT2D than in T2D patients. Elevated serum TGs were associated with young KPT2D patients.Conclusion: Lifestyle changes as well as lipid-lowering treatments might be effective in lowering the incidence of ketosis as well as stabilizing disease progression.Keywords: ketosis, triglycerides, hypertriglyceridemiaYe SRan HZhang HWu HLi WDu SSu QDove Medical PressarticleketosistriglycerideshypertriglyceridemiaSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 497-504 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ketosis triglycerides hypertriglyceridemia Specialties of internal medicine RC581-951
spellingShingle	ketosis triglycerides hypertriglyceridemia Specialties of internal medicine RC581-951 Ye S Ran H Zhang H Wu H Li W Du S Su Q Elevated Serum Triglycerides are Associated with Ketosis-Prone Type 2 Diabetes in Young Individuals
description	Shu Ye,1,* Hui Ran,1,* Hongmei Zhang,1 Hui Wu,2 Wen Li,1 Shichun Du,1 Qing Su1 1Department of Endocrinology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, People’s Republic of China; 2Department of Endocrinology, Zhejiang Provincial People’s Hospital, Hangzhou Medical College, Hangzhou, 310014, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shichun DuDepartment of Endocrinology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Kong Jiang Road 1665#, Shanghai, 200092, People’s Republic of ChinaEmail dushichun@xinhuamed.com.cnPurpose: Ketosis-prone type 2 diabetes (KPT2D) is increasingly recognized in young adults. However, the role of blood lipids in KPT2D, especially serum triglycerides (TGs), is not yet clearly understood.Patients and Methods: We retrospectively evaluated 409 young patients diagnosed with KPT2D or classical type 2 diabetes (T2D) attending an academic tertiary hospital. Clinical characteristics and laboratory findings were compared between KPT2D and T2D patients. ANOVA or a non-parametric test analyses were used to evaluate differences in clinical characteristics and laboratory findings. Multivariate regression analyses and stratified analyses were used to further investigate differences in serum TGs levels between KPT2D and T2D individuals.Results: KPT2D is a subtype of T2D with traits of overweight or obesity. However, hyperglycemia and impaired β-cell functions were more severe in KPT2D patients. Serum TGs levels were significantly higher (P = 0.0003) in KPT2D individuals. Furthermore, the proportion of very high serum TGs levels was 6-fold higher (P < 0.0001) in KPT2D than in T2D patients. Elevated serum TGs were associated with young KPT2D patients.Conclusion: Lifestyle changes as well as lipid-lowering treatments might be effective in lowering the incidence of ketosis as well as stabilizing disease progression.Keywords: ketosis, triglycerides, hypertriglyceridemia
format	article
author	Ye S Ran H Zhang H Wu H Li W Du S Su Q
author_facet	Ye S Ran H Zhang H Wu H Li W Du S Su Q
author_sort	Ye S
title	Elevated Serum Triglycerides are Associated with Ketosis-Prone Type 2 Diabetes in Young Individuals
title_short	Elevated Serum Triglycerides are Associated with Ketosis-Prone Type 2 Diabetes in Young Individuals
title_full	Elevated Serum Triglycerides are Associated with Ketosis-Prone Type 2 Diabetes in Young Individuals
title_fullStr	Elevated Serum Triglycerides are Associated with Ketosis-Prone Type 2 Diabetes in Young Individuals
title_full_unstemmed	Elevated Serum Triglycerides are Associated with Ketosis-Prone Type 2 Diabetes in Young Individuals
title_sort	elevated serum triglycerides are associated with ketosis-prone type 2 diabetes in young individuals
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/9fb10423193e4998b22fe9bc56af8c31
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Elevated Serum Triglycerides are Associated with Ketosis-Prone Type 2 Diabetes in Young Individuals

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