The Voronoi theory of the normal liver lobular architecture and its applicability in hepatic zonation

Abstract The precise characterization of the lobular architecture of the liver has been subject of investigation since the earliest historical publications, but an accurate model to describe the hepatic lobular microanatomy is yet to be proposed. Our aim was to evaluate whether Voronoi diagrams can...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	C. Lau, B. Kalantari, K. P. Batts, L. D. Ferrell, S. L. Nyberg, R. P. Graham, Roger K. Moreira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9fb3446a10e0438ca62b5f7b9bacc0d9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9fb3446a10e0438ca62b5f7b9bacc0d9
record_format	dspace
spelling	oai:doaj.org-article:9fb3446a10e0438ca62b5f7b9bacc0d92021-12-02T17:39:20ZThe Voronoi theory of the normal liver lobular architecture and its applicability in hepatic zonation10.1038/s41598-021-88699-22045-2322https://doaj.org/article/9fb3446a10e0438ca62b5f7b9bacc0d92021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88699-2https://doaj.org/toc/2045-2322Abstract The precise characterization of the lobular architecture of the liver has been subject of investigation since the earliest historical publications, but an accurate model to describe the hepatic lobular microanatomy is yet to be proposed. Our aim was to evaluate whether Voronoi diagrams can be used to describe the classic liver lobular architecture. We examined the histology of normal porcine and human livers and analyzed the geometric relationships of various microanatomic structures utilizing digital tools. The Voronoi diagram model described the organization of the hepatic classic lobules with overall accuracy nearly 90% based on known histologic landmarks. We have also designed a Voronoi-based algorithm of hepatic zonation, which also showed an overall zonal accuracy of nearly 90%. Therefore, we have presented evidence that Voronoi diagrams represent the basis of the two-dimensional organization of the normal liver and that this concept may have wide applicability in liver pathology and research.C. LauB. KalantariK. P. BattsL. D. FerrellS. L. NybergR. P. GrahamRoger K. MoreiraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q C. Lau B. Kalantari K. P. Batts L. D. Ferrell S. L. Nyberg R. P. Graham Roger K. Moreira The Voronoi theory of the normal liver lobular architecture and its applicability in hepatic zonation
description	Abstract The precise characterization of the lobular architecture of the liver has been subject of investigation since the earliest historical publications, but an accurate model to describe the hepatic lobular microanatomy is yet to be proposed. Our aim was to evaluate whether Voronoi diagrams can be used to describe the classic liver lobular architecture. We examined the histology of normal porcine and human livers and analyzed the geometric relationships of various microanatomic structures utilizing digital tools. The Voronoi diagram model described the organization of the hepatic classic lobules with overall accuracy nearly 90% based on known histologic landmarks. We have also designed a Voronoi-based algorithm of hepatic zonation, which also showed an overall zonal accuracy of nearly 90%. Therefore, we have presented evidence that Voronoi diagrams represent the basis of the two-dimensional organization of the normal liver and that this concept may have wide applicability in liver pathology and research.
format	article
author	C. Lau B. Kalantari K. P. Batts L. D. Ferrell S. L. Nyberg R. P. Graham Roger K. Moreira
author_facet	C. Lau B. Kalantari K. P. Batts L. D. Ferrell S. L. Nyberg R. P. Graham Roger K. Moreira
author_sort	C. Lau
title	The Voronoi theory of the normal liver lobular architecture and its applicability in hepatic zonation
title_short	The Voronoi theory of the normal liver lobular architecture and its applicability in hepatic zonation
title_full	The Voronoi theory of the normal liver lobular architecture and its applicability in hepatic zonation
title_fullStr	The Voronoi theory of the normal liver lobular architecture and its applicability in hepatic zonation
title_full_unstemmed	The Voronoi theory of the normal liver lobular architecture and its applicability in hepatic zonation
title_sort	voronoi theory of the normal liver lobular architecture and its applicability in hepatic zonation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9fb3446a10e0438ca62b5f7b9bacc0d9
work_keys_str_mv	AT clau thevoronoitheoryofthenormalliverlobulararchitectureanditsapplicabilityinhepaticzonation AT bkalantari thevoronoitheoryofthenormalliverlobulararchitectureanditsapplicabilityinhepaticzonation AT kpbatts thevoronoitheoryofthenormalliverlobulararchitectureanditsapplicabilityinhepaticzonation AT ldferrell thevoronoitheoryofthenormalliverlobulararchitectureanditsapplicabilityinhepaticzonation AT slnyberg thevoronoitheoryofthenormalliverlobulararchitectureanditsapplicabilityinhepaticzonation AT rpgraham thevoronoitheoryofthenormalliverlobulararchitectureanditsapplicabilityinhepaticzonation AT rogerkmoreira thevoronoitheoryofthenormalliverlobulararchitectureanditsapplicabilityinhepaticzonation AT clau voronoitheoryofthenormalliverlobulararchitectureanditsapplicabilityinhepaticzonation AT bkalantari voronoitheoryofthenormalliverlobulararchitectureanditsapplicabilityinhepaticzonation AT kpbatts voronoitheoryofthenormalliverlobulararchitectureanditsapplicabilityinhepaticzonation AT ldferrell voronoitheoryofthenormalliverlobulararchitectureanditsapplicabilityinhepaticzonation AT slnyberg voronoitheoryofthenormalliverlobulararchitectureanditsapplicabilityinhepaticzonation AT rpgraham voronoitheoryofthenormalliverlobulararchitectureanditsapplicabilityinhepaticzonation AT rogerkmoreira voronoitheoryofthenormalliverlobulararchitectureanditsapplicabilityinhepaticzonation
_version_	1718379839300304896

The Voronoi theory of the normal liver lobular architecture and its applicability in hepatic zonation

Ejemplares similares