Fundus autofluorescence in premature infants

Abstract To describe fundus autofluorescence (FAF) patterns in premature infants and to determine whether FAF increases gradually with increasing post-gestational age. This was a cross-sectional, observational and descriptive case series. FAF images were obtained from patients screened for Retinopat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Guillermo Salcedo-Villanueva, Yurico Lopez-Contreras, Ana Gonzalez-H. Leon, Juan C. Romo-Aguas, Gerardo Garcia-Aguirre, Linda A. Cernichiaro-Espinosa, Maria A. Martinez-Castellanos, Hugo Quiroz-Mercado
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9fb3e14ebf4a47a28b9e9e35d5d2f297
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9fb3e14ebf4a47a28b9e9e35d5d2f297
record_format	dspace
spelling	oai:doaj.org-article:9fb3e14ebf4a47a28b9e9e35d5d2f2972021-12-02T18:27:49ZFundus autofluorescence in premature infants10.1038/s41598-021-88262-z2045-2322https://doaj.org/article/9fb3e14ebf4a47a28b9e9e35d5d2f2972021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88262-zhttps://doaj.org/toc/2045-2322Abstract To describe fundus autofluorescence (FAF) patterns in premature infants and to determine whether FAF increases gradually with increasing post-gestational age. This was a cross-sectional, observational and descriptive case series. FAF images were obtained from patients screened for Retinopathy of Prematurity. The presence of the following hypo-autofluorescence areas/structures was graded and ranked: macular pigment (foveal centre), optic nerve head, peripapillary vessels/vascular arcade (PP/VA), and equatorial vessels (EqV). Ranks were attributed to the number of structures visualized from the posterior pole towards the periphery. The rank of FAF could then be analysed by Spearman’s correlation against age. Additionally, patients were divided by age into group 1 (< 40 weeks of corrected gestational age (WCGA)) and group 2 (> 40 WCGA). Differences between groups were tested with the Mann–Whitney U test. Thirteen patients were analysed. The mean WCGA at examination was 47.85 weeks. Spearman’s correlation showed a strong positive correlation (r = 0.714) (P = 0.006) of FAF and WCGA. The Mann–Whitney U test revealed that the PP/VA and EqV were significantly more visible at > 40 WCGA than at < 40 WCGA (8.0 [P = 0.016] and 7.5 [P = 0.03], respectively). Patterns of FAF are described for the first time in premature infants. FAF increases gradually with age and centrifugally from the posterior pole towards the equator in premature infants.Guillermo Salcedo-VillanuevaYurico Lopez-ContrerasAna Gonzalez-H. LeonJuan C. Romo-AguasGerardo Garcia-AguirreLinda A. Cernichiaro-EspinosaMaria A. Martinez-CastellanosHugo Quiroz-MercadoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guillermo Salcedo-Villanueva Yurico Lopez-Contreras Ana Gonzalez-H. Leon Juan C. Romo-Aguas Gerardo Garcia-Aguirre Linda A. Cernichiaro-Espinosa Maria A. Martinez-Castellanos Hugo Quiroz-Mercado Fundus autofluorescence in premature infants
description	Abstract To describe fundus autofluorescence (FAF) patterns in premature infants and to determine whether FAF increases gradually with increasing post-gestational age. This was a cross-sectional, observational and descriptive case series. FAF images were obtained from patients screened for Retinopathy of Prematurity. The presence of the following hypo-autofluorescence areas/structures was graded and ranked: macular pigment (foveal centre), optic nerve head, peripapillary vessels/vascular arcade (PP/VA), and equatorial vessels (EqV). Ranks were attributed to the number of structures visualized from the posterior pole towards the periphery. The rank of FAF could then be analysed by Spearman’s correlation against age. Additionally, patients were divided by age into group 1 (< 40 weeks of corrected gestational age (WCGA)) and group 2 (> 40 WCGA). Differences between groups were tested with the Mann–Whitney U test. Thirteen patients were analysed. The mean WCGA at examination was 47.85 weeks. Spearman’s correlation showed a strong positive correlation (r = 0.714) (P = 0.006) of FAF and WCGA. The Mann–Whitney U test revealed that the PP/VA and EqV were significantly more visible at > 40 WCGA than at < 40 WCGA (8.0 [P = 0.016] and 7.5 [P = 0.03], respectively). Patterns of FAF are described for the first time in premature infants. FAF increases gradually with age and centrifugally from the posterior pole towards the equator in premature infants.
format	article
author	Guillermo Salcedo-Villanueva Yurico Lopez-Contreras Ana Gonzalez-H. Leon Juan C. Romo-Aguas Gerardo Garcia-Aguirre Linda A. Cernichiaro-Espinosa Maria A. Martinez-Castellanos Hugo Quiroz-Mercado
author_facet	Guillermo Salcedo-Villanueva Yurico Lopez-Contreras Ana Gonzalez-H. Leon Juan C. Romo-Aguas Gerardo Garcia-Aguirre Linda A. Cernichiaro-Espinosa Maria A. Martinez-Castellanos Hugo Quiroz-Mercado
author_sort	Guillermo Salcedo-Villanueva
title	Fundus autofluorescence in premature infants
title_short	Fundus autofluorescence in premature infants
title_full	Fundus autofluorescence in premature infants
title_fullStr	Fundus autofluorescence in premature infants
title_full_unstemmed	Fundus autofluorescence in premature infants
title_sort	fundus autofluorescence in premature infants
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9fb3e14ebf4a47a28b9e9e35d5d2f297
work_keys_str_mv	AT guillermosalcedovillanueva fundusautofluorescenceinprematureinfants AT yuricolopezcontreras fundusautofluorescenceinprematureinfants AT anagonzalezhleon fundusautofluorescenceinprematureinfants AT juancromoaguas fundusautofluorescenceinprematureinfants AT gerardogarciaaguirre fundusautofluorescenceinprematureinfants AT lindaacernichiaroespinosa fundusautofluorescenceinprematureinfants AT mariaamartinezcastellanos fundusautofluorescenceinprematureinfants AT hugoquirozmercado fundusautofluorescenceinprematureinfants
_version_	1718377996810715136

Fundus autofluorescence in premature infants

Ejemplares similares