Platelet Membranes Coated Gold Nanocages for Tumor Targeted Drug Delivery and Amplificated Low-Dose Radiotherapy

Continuous high doses of radiation can cause irreversible side effects and radiation resistance; thus, advanced radiosensitizers are urgently needed. To overcome this problem, we developed a nano platelet radiosensitization system (PCA) by coating the chemotherapeutic drug cisplatin (CDDP) loaded go...

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Autores principales:	Mingzhu Chen, Ping Wang, Dazhen Jiang, Zhirong Bao, Hong Quan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	platelet membranes gold nanocages drug delivery low-dose radiotherapy cisplatin Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/9fb4a9b552f34f1ead41e0f8fc7af4fe
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spelling	oai:doaj.org-article:9fb4a9b552f34f1ead41e0f8fc7af4fe2021-11-30T17:49:28ZPlatelet Membranes Coated Gold Nanocages for Tumor Targeted Drug Delivery and Amplificated Low-Dose Radiotherapy2234-943X10.3389/fonc.2021.793006https://doaj.org/article/9fb4a9b552f34f1ead41e0f8fc7af4fe2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.793006/fullhttps://doaj.org/toc/2234-943XContinuous high doses of radiation can cause irreversible side effects and radiation resistance; thus, advanced radiosensitizers are urgently needed. To overcome this problem, we developed a nano platelet radiosensitization system (PCA) by coating the chemotherapeutic drug cisplatin (CDDP) loaded gold nanocages (AuNs) within the platelet membrane. The developed PCA system may enable AuNs to have immune escape and targeting capabilities. After administration, PCA will actively target tumor cells and avoid being cleared by the immune system. Subsequently, CDDP, which destroys tumor cell DNA, can not only kill tumor cells directly but also combine with AuNs, which deposit radiation energy into tumor tissues, reducing RT resistance. In vivo and in vitro studies revealed that the combination of PCA with RT (2Gy) efficiently inhibits tumor proliferation without causing side effects such as inflammation. To conclude, this is the first attempt to use platelet membranes to correctly transport AuNs while also accomplishing low-dose RT, which could help AuNs-based tumor RT become more effective.Mingzhu ChenPing WangDazhen JiangZhirong BaoHong QuanFrontiers Media S.A.articleplatelet membranesgold nanocagesdrug deliverylow-dose radiotherapycisplatinNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	platelet membranes gold nanocages drug delivery low-dose radiotherapy cisplatin Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	platelet membranes gold nanocages drug delivery low-dose radiotherapy cisplatin Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Mingzhu Chen Ping Wang Dazhen Jiang Zhirong Bao Hong Quan Platelet Membranes Coated Gold Nanocages for Tumor Targeted Drug Delivery and Amplificated Low-Dose Radiotherapy
description	Continuous high doses of radiation can cause irreversible side effects and radiation resistance; thus, advanced radiosensitizers are urgently needed. To overcome this problem, we developed a nano platelet radiosensitization system (PCA) by coating the chemotherapeutic drug cisplatin (CDDP) loaded gold nanocages (AuNs) within the platelet membrane. The developed PCA system may enable AuNs to have immune escape and targeting capabilities. After administration, PCA will actively target tumor cells and avoid being cleared by the immune system. Subsequently, CDDP, which destroys tumor cell DNA, can not only kill tumor cells directly but also combine with AuNs, which deposit radiation energy into tumor tissues, reducing RT resistance. In vivo and in vitro studies revealed that the combination of PCA with RT (2Gy) efficiently inhibits tumor proliferation without causing side effects such as inflammation. To conclude, this is the first attempt to use platelet membranes to correctly transport AuNs while also accomplishing low-dose RT, which could help AuNs-based tumor RT become more effective.
format	article
author	Mingzhu Chen Ping Wang Dazhen Jiang Zhirong Bao Hong Quan
author_facet	Mingzhu Chen Ping Wang Dazhen Jiang Zhirong Bao Hong Quan
author_sort	Mingzhu Chen
title	Platelet Membranes Coated Gold Nanocages for Tumor Targeted Drug Delivery and Amplificated Low-Dose Radiotherapy
title_short	Platelet Membranes Coated Gold Nanocages for Tumor Targeted Drug Delivery and Amplificated Low-Dose Radiotherapy
title_full	Platelet Membranes Coated Gold Nanocages for Tumor Targeted Drug Delivery and Amplificated Low-Dose Radiotherapy
title_fullStr	Platelet Membranes Coated Gold Nanocages for Tumor Targeted Drug Delivery and Amplificated Low-Dose Radiotherapy
title_full_unstemmed	Platelet Membranes Coated Gold Nanocages for Tumor Targeted Drug Delivery and Amplificated Low-Dose Radiotherapy
title_sort	platelet membranes coated gold nanocages for tumor targeted drug delivery and amplificated low-dose radiotherapy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9fb4a9b552f34f1ead41e0f8fc7af4fe
work_keys_str_mv	AT mingzhuchen plateletmembranescoatedgoldnanocagesfortumortargeteddrugdeliveryandamplificatedlowdoseradiotherapy AT pingwang plateletmembranescoatedgoldnanocagesfortumortargeteddrugdeliveryandamplificatedlowdoseradiotherapy AT dazhenjiang plateletmembranescoatedgoldnanocagesfortumortargeteddrugdeliveryandamplificatedlowdoseradiotherapy AT zhirongbao plateletmembranescoatedgoldnanocagesfortumortargeteddrugdeliveryandamplificatedlowdoseradiotherapy AT hongquan plateletmembranescoatedgoldnanocagesfortumortargeteddrugdeliveryandamplificatedlowdoseradiotherapy
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Platelet Membranes Coated Gold Nanocages for Tumor Targeted Drug Delivery and Amplificated Low-Dose Radiotherapy

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