Prognostic implication of PD‐L1 polymorphisms in non‐small cell lung cancer treated with radiotherapy

Abstract Background To investigate the impact of programmed death‐ligand 1 (PD‐L1) polymorphisms on the prognosis of non‐small cell lung cancer (NSCLC) patients treated with curative radiotherapy. Methods Four single nucleotide polymorphisms (SNPs) (rs822336G>C, rs822337T>A, rs822338C>T, an...

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Autores principales:	Min Kyu Kang, Shin Yup Lee, Jin Eun Choi, Sook Kyung Do, Moon‐June Cho, Jun‐Sang Kim, Jae Yong Park
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	non‐small cell lung cancer PD‐L1 polymorphisms radiotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/9fb4f3f87b164d22987a18702f7ec04d
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spelling	oai:doaj.org-article:9fb4f3f87b164d22987a18702f7ec04d2021-11-22T09:08:48ZPrognostic implication of PD‐L1 polymorphisms in non‐small cell lung cancer treated with radiotherapy2045-763410.1002/cam4.4329https://doaj.org/article/9fb4f3f87b164d22987a18702f7ec04d2021-11-01T00:00:00Zhttps://doi.org/10.1002/cam4.4329https://doaj.org/toc/2045-7634Abstract Background To investigate the impact of programmed death‐ligand 1 (PD‐L1) polymorphisms on the prognosis of non‐small cell lung cancer (NSCLC) patients treated with curative radiotherapy. Methods Four single nucleotide polymorphisms (SNPs) (rs822336G>C, rs822337T>A, rs822338C>T, and rs2297136A>G) in the PD‐L1 gene were evaluated in 124 NSCLC patients. Clinical stage was I in 28, II in 17, and III in 79 patients. Fifty‐seven patients received radiotherapy alone, including 28 patients who received stereotactic body radiotherapy. Sixty‐seven patients received sequential or concurrent chemoradiotherapy. Risk factors for survival outcomes were analyzed with the log‐rank test and multivariate Cox proportional hazards models. Results The rs822336GC+CC genotype was associated with better overall survival (OS) (hazard ratio [HR] = 0.60, 95% confidence interval [CI] = 0.37–0.97, p = 0.036) and regional failure‐free survival (RFFS) (HR = 0.32, 95% CI = 0.14–0.76, p = 0.009), compared with rs822336GG genotype. The rs822337TA+AA genotype was associated with better OS (HR =0.54, 95% CI = 0.34–0.88, p = 0.014), progression‐free survival (PFS) (HR = 0.64, 95% CI = 0.41–0.99, p = 0.046), and RFFS (HR = 0.38, 95% CI = 0.17–0.81, p = 0.013), compared with rs822337TT genotype. Three SNPs (rs822336, rs822337, and rs822338) were in linkage disequilibrium. Combined GTC and GTT (GT) haplotype was associated with significantly worse OS (p = 0.018), PFS (p = 0.044), and RFFS (p = 0.038), compared with those with other combined haplotypes. Patients with diplotypes of two GT haplotypes showed significantly worse OS (p = 0.023) and RFFS (p = 0.014) than those with other diplotypes. Conclusions These findings suggest that PD‐L1 polymorphisms could be predictive markers for NSCLC patients receiving radiotherapy.Min Kyu KangShin Yup LeeJin Eun ChoiSook Kyung DoMoon‐June ChoJun‐Sang KimJae Yong ParkWileyarticlenon‐small cell lung cancerPD‐L1polymorphismsradiotherapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Medicine, Vol 10, Iss 22, Pp 8071-8078 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	non‐small cell lung cancer PD‐L1 polymorphisms radiotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	non‐small cell lung cancer PD‐L1 polymorphisms radiotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Min Kyu Kang Shin Yup Lee Jin Eun Choi Sook Kyung Do Moon‐June Cho Jun‐Sang Kim Jae Yong Park Prognostic implication of PD‐L1 polymorphisms in non‐small cell lung cancer treated with radiotherapy
description	Abstract Background To investigate the impact of programmed death‐ligand 1 (PD‐L1) polymorphisms on the prognosis of non‐small cell lung cancer (NSCLC) patients treated with curative radiotherapy. Methods Four single nucleotide polymorphisms (SNPs) (rs822336G>C, rs822337T>A, rs822338C>T, and rs2297136A>G) in the PD‐L1 gene were evaluated in 124 NSCLC patients. Clinical stage was I in 28, II in 17, and III in 79 patients. Fifty‐seven patients received radiotherapy alone, including 28 patients who received stereotactic body radiotherapy. Sixty‐seven patients received sequential or concurrent chemoradiotherapy. Risk factors for survival outcomes were analyzed with the log‐rank test and multivariate Cox proportional hazards models. Results The rs822336GC+CC genotype was associated with better overall survival (OS) (hazard ratio [HR] = 0.60, 95% confidence interval [CI] = 0.37–0.97, p = 0.036) and regional failure‐free survival (RFFS) (HR = 0.32, 95% CI = 0.14–0.76, p = 0.009), compared with rs822336GG genotype. The rs822337TA+AA genotype was associated with better OS (HR =0.54, 95% CI = 0.34–0.88, p = 0.014), progression‐free survival (PFS) (HR = 0.64, 95% CI = 0.41–0.99, p = 0.046), and RFFS (HR = 0.38, 95% CI = 0.17–0.81, p = 0.013), compared with rs822337TT genotype. Three SNPs (rs822336, rs822337, and rs822338) were in linkage disequilibrium. Combined GTC and GTT (GT) haplotype was associated with significantly worse OS (p = 0.018), PFS (p = 0.044), and RFFS (p = 0.038), compared with those with other combined haplotypes. Patients with diplotypes of two GT haplotypes showed significantly worse OS (p = 0.023) and RFFS (p = 0.014) than those with other diplotypes. Conclusions These findings suggest that PD‐L1 polymorphisms could be predictive markers for NSCLC patients receiving radiotherapy.
format	article
author	Min Kyu Kang Shin Yup Lee Jin Eun Choi Sook Kyung Do Moon‐June Cho Jun‐Sang Kim Jae Yong Park
author_facet	Min Kyu Kang Shin Yup Lee Jin Eun Choi Sook Kyung Do Moon‐June Cho Jun‐Sang Kim Jae Yong Park
author_sort	Min Kyu Kang
title	Prognostic implication of PD‐L1 polymorphisms in non‐small cell lung cancer treated with radiotherapy
title_short	Prognostic implication of PD‐L1 polymorphisms in non‐small cell lung cancer treated with radiotherapy
title_full	Prognostic implication of PD‐L1 polymorphisms in non‐small cell lung cancer treated with radiotherapy
title_fullStr	Prognostic implication of PD‐L1 polymorphisms in non‐small cell lung cancer treated with radiotherapy
title_full_unstemmed	Prognostic implication of PD‐L1 polymorphisms in non‐small cell lung cancer treated with radiotherapy
title_sort	prognostic implication of pd‐l1 polymorphisms in non‐small cell lung cancer treated with radiotherapy
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/9fb4f3f87b164d22987a18702f7ec04d
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Prognostic implication of PD‐L1 polymorphisms in non‐small cell lung cancer treated with radiotherapy

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