Correlations between bone turnover markers, serum magnesium and bone mass density in postmenopausal osteoporosis

Ovidiu Alexandru Mederle,1,* Melania Balas,2,* Sorin Dumitru Ioanoviciu,3,* Camelia-Vidita Gurban,4 Anca Tudor,5 Claudia Borza6 1Department of Microscopic Morphology/Histology, Angiogenesis Research Center, 2Department of Endocrinology, 3Department of First Internal Medicine, 4Department of Biochem...

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Autores principales:	Mederle OA, Balas M, Ioanoviciu SD, Gurban CV, Tudor A, Borza C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	osteoporosis bone turnover markers magnesium Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/9fb5273ecf3d4718a0057eb50a548d16
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spelling	oai:doaj.org-article:9fb5273ecf3d4718a0057eb50a548d162021-12-02T04:07:49ZCorrelations between bone turnover markers, serum magnesium and bone mass density in postmenopausal osteoporosis1178-1998https://doaj.org/article/9fb5273ecf3d4718a0057eb50a548d162018-08-01T00:00:00Zhttps://www.dovepress.com/correlations-between-bone-turnover-markers-serum-magnesium-and-bone-ma-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Ovidiu Alexandru Mederle,1,* Melania Balas,2,* Sorin Dumitru Ioanoviciu,3,* Camelia-Vidita Gurban,4 Anca Tudor,5 Claudia Borza6 1Department of Microscopic Morphology/Histology, Angiogenesis Research Center, 2Department of Endocrinology, 3Department of First Internal Medicine, 4Department of Biochemistry and Pharmacology, 5Department of Informatics and Medical Biostatistics, 6Department of Pathophysiology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Timisoara, Romania *These authors contributed equally to this work Introduction: Bone mass density (BMD) is still the gold standard for the diagnosis of osteoporosis, but bone turnover markers (BTMs) can provide helpful information regarding the bone remodeling process. The aim of this study was to determine the correlations between BMD and serum levels of BTMs (tartrate-resistant acid phosphatase-5b [TRAP-5b]), bone-specific alkaline phosphatase (BSAP), estradiol (E2), and magnesium (Mg[2+]) ion concentrations in postmenopausal osteoporotic women as compared to healthy postmenopausal subjects. Materials and methods: The study included 132 women with postmenopausal osteoporosis and 81 healthy postmenopausal women without osteoporosis. Dual-energy X-ray absorptiometry scan assessed BMD at different skeleton sites. Serum levels of E2, BSAP, and TRAP-5b were measured by enzyme linked immunosorbent assay. Serum levels of Mg(2+) were determined using the colorimetric spectrometry technique. Results: Serum levels of BTMs were significantly higher in osteoporotic women than in controls. BSAP has a moderate sensitivity (76.5%) and specificity (84.3%) (cutoff point 21.27 U/L). At a cutoff point of 3.45 U/L, TRAP-5b presented a sensitivity of 86.3% and a higher specificity of 90.6%. Osteoporotic patients showed significantly lower concentrations of serum Mg(2+) than the control group. Mg(2+) levels correlated positively with BMD values (r=0.747, P<0.0001). Furthermore, Mg(2+) concentrations correlated positively with E2 levels (r=0.684, P<0.0001). Spine BMD correlated negatively with BSAP levels (r=-0.36, P<0.0001). Conclusion: Our study showed that BMD correlates negatively with BTMs and positively with E2 and Mg(2+) levels. TRAP-5b presents a good specificity in identifying patients with postmenopausal osteoporosis. Keywords: bone mass density, tartrate-resistant acid phosphatase-5b, bone-specific alkaline phosphataseMederle OABalas MIoanoviciu SDGurban CVTudor ABorza CDove Medical Pressarticleosteoporosisbone turnover markersmagnesiumGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 1383-1389 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteoporosis bone turnover markers magnesium Geriatrics RC952-954.6
spellingShingle	osteoporosis bone turnover markers magnesium Geriatrics RC952-954.6 Mederle OA Balas M Ioanoviciu SD Gurban CV Tudor A Borza C Correlations between bone turnover markers, serum magnesium and bone mass density in postmenopausal osteoporosis
description	Ovidiu Alexandru Mederle,1,* Melania Balas,2,* Sorin Dumitru Ioanoviciu,3,* Camelia-Vidita Gurban,4 Anca Tudor,5 Claudia Borza6 1Department of Microscopic Morphology/Histology, Angiogenesis Research Center, 2Department of Endocrinology, 3Department of First Internal Medicine, 4Department of Biochemistry and Pharmacology, 5Department of Informatics and Medical Biostatistics, 6Department of Pathophysiology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Timisoara, Romania *These authors contributed equally to this work Introduction: Bone mass density (BMD) is still the gold standard for the diagnosis of osteoporosis, but bone turnover markers (BTMs) can provide helpful information regarding the bone remodeling process. The aim of this study was to determine the correlations between BMD and serum levels of BTMs (tartrate-resistant acid phosphatase-5b [TRAP-5b]), bone-specific alkaline phosphatase (BSAP), estradiol (E2), and magnesium (Mg[2+]) ion concentrations in postmenopausal osteoporotic women as compared to healthy postmenopausal subjects. Materials and methods: The study included 132 women with postmenopausal osteoporosis and 81 healthy postmenopausal women without osteoporosis. Dual-energy X-ray absorptiometry scan assessed BMD at different skeleton sites. Serum levels of E2, BSAP, and TRAP-5b were measured by enzyme linked immunosorbent assay. Serum levels of Mg(2+) were determined using the colorimetric spectrometry technique. Results: Serum levels of BTMs were significantly higher in osteoporotic women than in controls. BSAP has a moderate sensitivity (76.5%) and specificity (84.3%) (cutoff point 21.27 U/L). At a cutoff point of 3.45 U/L, TRAP-5b presented a sensitivity of 86.3% and a higher specificity of 90.6%. Osteoporotic patients showed significantly lower concentrations of serum Mg(2+) than the control group. Mg(2+) levels correlated positively with BMD values (r=0.747, P<0.0001). Furthermore, Mg(2+) concentrations correlated positively with E2 levels (r=0.684, P<0.0001). Spine BMD correlated negatively with BSAP levels (r=-0.36, P<0.0001). Conclusion: Our study showed that BMD correlates negatively with BTMs and positively with E2 and Mg(2+) levels. TRAP-5b presents a good specificity in identifying patients with postmenopausal osteoporosis. Keywords: bone mass density, tartrate-resistant acid phosphatase-5b, bone-specific alkaline phosphatase
format	article
author	Mederle OA Balas M Ioanoviciu SD Gurban CV Tudor A Borza C
author_facet	Mederle OA Balas M Ioanoviciu SD Gurban CV Tudor A Borza C
author_sort	Mederle OA
title	Correlations between bone turnover markers, serum magnesium and bone mass density in postmenopausal osteoporosis
title_short	Correlations between bone turnover markers, serum magnesium and bone mass density in postmenopausal osteoporosis
title_full	Correlations between bone turnover markers, serum magnesium and bone mass density in postmenopausal osteoporosis
title_fullStr	Correlations between bone turnover markers, serum magnesium and bone mass density in postmenopausal osteoporosis
title_full_unstemmed	Correlations between bone turnover markers, serum magnesium and bone mass density in postmenopausal osteoporosis
title_sort	correlations between bone turnover markers, serum magnesium and bone mass density in postmenopausal osteoporosis
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/9fb5273ecf3d4718a0057eb50a548d16
work_keys_str_mv	AT mederleoa correlationsbetweenboneturnovermarkersserummagnesiumandbonemassdensityinpostmenopausalosteoporosis AT balasm correlationsbetweenboneturnovermarkersserummagnesiumandbonemassdensityinpostmenopausalosteoporosis AT ioanoviciusd correlationsbetweenboneturnovermarkersserummagnesiumandbonemassdensityinpostmenopausalosteoporosis AT gurbancv correlationsbetweenboneturnovermarkersserummagnesiumandbonemassdensityinpostmenopausalosteoporosis AT tudora correlationsbetweenboneturnovermarkersserummagnesiumandbonemassdensityinpostmenopausalosteoporosis AT borzac correlationsbetweenboneturnovermarkersserummagnesiumandbonemassdensityinpostmenopausalosteoporosis
_version_	1718401448493973504

Correlations between bone turnover markers, serum magnesium and bone mass density in postmenopausal osteoporosis

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