Neutrophil extracellular traps and thrombogenesis in COVID-19 patients

COVID-19 has caused significant morbidity and mortality around the world. Recent reports point toward the “cytokine storm” as core of pathogenesis in SAR-CoV-2-induced acute lung injury, acute respiratory distress syndrome (ARDS), coagulopathy, and multiorgan failure. We have presented clinical data...

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Autor principal:	Ahmed Yaqinuddin
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	coronavirus covid-19 neutrophil extracellular traps neutrophils sars thrombosis vasculitis Medicine R
Acceso en línea:	https://doaj.org/article/9fb8e96a4cc847dfb6241217099ee297
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spelling	oai:doaj.org-article:9fb8e96a4cc847dfb6241217099ee2972021-11-12T10:25:23ZNeutrophil extracellular traps and thrombogenesis in COVID-19 patients1735-19951735-713610.4103/jrms.JRMS_750_20https://doaj.org/article/9fb8e96a4cc847dfb6241217099ee2972021-01-01T00:00:00Zhttp://www.jmsjournal.net/article.asp?issn=1735-1995;year=2021;volume=26;issue=1;spage=96;epage=96;aulast=Yaqinuddinhttps://doaj.org/toc/1735-1995https://doaj.org/toc/1735-7136COVID-19 has caused significant morbidity and mortality around the world. Recent reports point toward the “cytokine storm” as core of pathogenesis in SAR-CoV-2-induced acute lung injury, acute respiratory distress syndrome (ARDS), coagulopathy, and multiorgan failure. We have presented clinical data here wherein cytokine levels in COVID-19 patients do not match typical cytokine storm seen in ARDS. Interestingly, COVID-19 patients in early disease present with hypoxemia with no significant respiratory dysfunction. In addition, it is reported that hospitalized COVID-19 patients have a high incidence of thrombotic complications, especially involving the pulmonary vasculature. We hypothesized that core to pathogenesis of COVID-19 is the dysregulation of neutrophils, which culminates in excessive release of neutrophil extracellular traps (NETs). Recently, an increasing amount of NETs have been seen in sera of severe COVID-19 patients. We have discussed here mechanisms involved which lead to thrombogenesis and vasculitis because of excessive release of NETs.Ahmed YaqinuddinWolters Kluwer Medknow Publicationsarticlecoronaviruscovid-19neutrophil extracellular trapsneutrophilssarsthrombosisvasculitisMedicineRENJournal of Research in Medical Sciences, Vol 26, Iss 1, Pp 96-96 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	coronavirus covid-19 neutrophil extracellular traps neutrophils sars thrombosis vasculitis Medicine R
spellingShingle	coronavirus covid-19 neutrophil extracellular traps neutrophils sars thrombosis vasculitis Medicine R Ahmed Yaqinuddin Neutrophil extracellular traps and thrombogenesis in COVID-19 patients
description	COVID-19 has caused significant morbidity and mortality around the world. Recent reports point toward the “cytokine storm” as core of pathogenesis in SAR-CoV-2-induced acute lung injury, acute respiratory distress syndrome (ARDS), coagulopathy, and multiorgan failure. We have presented clinical data here wherein cytokine levels in COVID-19 patients do not match typical cytokine storm seen in ARDS. Interestingly, COVID-19 patients in early disease present with hypoxemia with no significant respiratory dysfunction. In addition, it is reported that hospitalized COVID-19 patients have a high incidence of thrombotic complications, especially involving the pulmonary vasculature. We hypothesized that core to pathogenesis of COVID-19 is the dysregulation of neutrophils, which culminates in excessive release of neutrophil extracellular traps (NETs). Recently, an increasing amount of NETs have been seen in sera of severe COVID-19 patients. We have discussed here mechanisms involved which lead to thrombogenesis and vasculitis because of excessive release of NETs.
format	article
author	Ahmed Yaqinuddin
author_facet	Ahmed Yaqinuddin
author_sort	Ahmed Yaqinuddin
title	Neutrophil extracellular traps and thrombogenesis in COVID-19 patients
title_short	Neutrophil extracellular traps and thrombogenesis in COVID-19 patients
title_full	Neutrophil extracellular traps and thrombogenesis in COVID-19 patients
title_fullStr	Neutrophil extracellular traps and thrombogenesis in COVID-19 patients
title_full_unstemmed	Neutrophil extracellular traps and thrombogenesis in COVID-19 patients
title_sort	neutrophil extracellular traps and thrombogenesis in covid-19 patients
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/9fb8e96a4cc847dfb6241217099ee297
work_keys_str_mv	AT ahmedyaqinuddin neutrophilextracellulartrapsandthrombogenesisincovid19patients
_version_	1718431006592073728

Neutrophil extracellular traps and thrombogenesis in COVID-19 patients

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