mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation

mTORC1 is crucial for chondrocyte proliferation and bone growth, but the downstream signalling is not clear. Here, the authors use rapamycin and chondrocyte-specific Tsc1 knockout mice to show that S6K1 can cause nuclear accumulation of Gli2, thus driving PTHrP expression and preventing terminal dif...

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Autores principales:	Bo Yan, Zhongmin Zhang, Dadi Jin, Chen Cai, Chunhong Jia, Wen Liu, Ting Wang, Shengfa Li, Haiyan Zhang, Bin Huang, Pinglin Lai, Hua Wang, Anling Liu, Chun Zeng, Daozhang Cai, Yu Jiang, Xiaochun Bai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9fbf617daa9f4739bde05778746bcc00
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spelling	oai:doaj.org-article:9fbf617daa9f4739bde05778746bcc002021-12-02T15:34:31ZmTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation10.1038/ncomms111512041-1723https://doaj.org/article/9fbf617daa9f4739bde05778746bcc002016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11151https://doaj.org/toc/2041-1723mTORC1 is crucial for chondrocyte proliferation and bone growth, but the downstream signalling is not clear. Here, the authors use rapamycin and chondrocyte-specific Tsc1 knockout mice to show that S6K1 can cause nuclear accumulation of Gli2, thus driving PTHrP expression and preventing terminal differentiation of prehypertrophic chondrocytes.Bo YanZhongmin ZhangDadi JinChen CaiChunhong JiaWen LiuTing WangShengfa LiHaiyan ZhangBin HuangPinglin LaiHua WangAnling LiuChun ZengDaozhang CaiYu JiangXiaochun BaiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bo Yan Zhongmin Zhang Dadi Jin Chen Cai Chunhong Jia Wen Liu Ting Wang Shengfa Li Haiyan Zhang Bin Huang Pinglin Lai Hua Wang Anling Liu Chun Zeng Daozhang Cai Yu Jiang Xiaochun Bai mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation
description	mTORC1 is crucial for chondrocyte proliferation and bone growth, but the downstream signalling is not clear. Here, the authors use rapamycin and chondrocyte-specific Tsc1 knockout mice to show that S6K1 can cause nuclear accumulation of Gli2, thus driving PTHrP expression and preventing terminal differentiation of prehypertrophic chondrocytes.
format	article
author	Bo Yan Zhongmin Zhang Dadi Jin Chen Cai Chunhong Jia Wen Liu Ting Wang Shengfa Li Haiyan Zhang Bin Huang Pinglin Lai Hua Wang Anling Liu Chun Zeng Daozhang Cai Yu Jiang Xiaochun Bai
author_facet	Bo Yan Zhongmin Zhang Dadi Jin Chen Cai Chunhong Jia Wen Liu Ting Wang Shengfa Li Haiyan Zhang Bin Huang Pinglin Lai Hua Wang Anling Liu Chun Zeng Daozhang Cai Yu Jiang Xiaochun Bai
author_sort	Bo Yan
title	mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation
title_short	mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation
title_full	mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation
title_fullStr	mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation
title_full_unstemmed	mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation
title_sort	mtorc1 regulates pthrp to coordinate chondrocyte growth, proliferation and differentiation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/9fbf617daa9f4739bde05778746bcc00
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mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation

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