mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation

mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation

mTORC1 is crucial for chondrocyte proliferation and bone growth, but the downstream signalling is not clear. Here, the authors use rapamycin and chondrocyte-specific Tsc1 knockout mice to show that S6K1 can cause nuclear accumulation of Gli2, thus driving PTHrP expression and preventing terminal dif...

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Autores principales: Bo Yan, Zhongmin Zhang, Dadi Jin, Chen Cai, Chunhong Jia, Wen Liu, Ting Wang, Shengfa Li, Haiyan Zhang, Bin Huang, Pinglin Lai, Hua Wang, Anling Liu, Chun Zeng, Daozhang Cai, Yu Jiang, Xiaochun Bai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/9fbf617daa9f4739bde05778746bcc00
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