Mesolimbic dopamine D2 receptors and neural representations of subjective value

Abstract The process by which the value of delayed rewards is discounted varies from person to person. It has been suggested that these individual differences in subjective valuation of delayed rewards are supported by mesolimbic dopamine D2-like receptors (D2Rs) in the ventral striatum. However, no...

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Autores principales:	Jaime J. Castrellon, Jacob S. Young, Linh C. Dang, Ronald L. Cowan, David H. Zald, Gregory R. Samanez-Larkin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9fc1ee61e58b48148c8f889cf15b9b08
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spelling	oai:doaj.org-article:9fc1ee61e58b48148c8f889cf15b9b082021-12-02T13:34:54ZMesolimbic dopamine D2 receptors and neural representations of subjective value10.1038/s41598-019-56858-12045-2322https://doaj.org/article/9fc1ee61e58b48148c8f889cf15b9b082019-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-56858-1https://doaj.org/toc/2045-2322Abstract The process by which the value of delayed rewards is discounted varies from person to person. It has been suggested that these individual differences in subjective valuation of delayed rewards are supported by mesolimbic dopamine D2-like receptors (D2Rs) in the ventral striatum. However, no study to date has documented an association between direct measures of dopamine receptors and neural representations of subjective value in humans. Here, we examined whether individual differences in D2R availability were related to neural subjective value signals during decision making. Human participants completed a monetary delay discounting task during an fMRI scan and on a separate visit completed a PET scan with the high affinity D2R tracer [18 F]fallypride. Region-of-interest analyses revealed that D2R availability in the ventral striatum was positively correlated with subjective value-related activity in the ventromedial prefrontal cortex and midbrain but not with choice behavior. Whole-brain analyses revealed a positive correlation between ventral striatum D2R availability and subjective value-related activity in the left inferior frontal gyrus and superior insula. These findings identify a link between a direct measure of mesolimbic dopamine function and subjective value representation in humans and suggest a mechanism by which individuals vary in neural representation of discounted subjective value.Jaime J. CastrellonJacob S. YoungLinh C. DangRonald L. CowanDavid H. ZaldGregory R. Samanez-LarkinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jaime J. Castrellon Jacob S. Young Linh C. Dang Ronald L. Cowan David H. Zald Gregory R. Samanez-Larkin Mesolimbic dopamine D2 receptors and neural representations of subjective value
description	Abstract The process by which the value of delayed rewards is discounted varies from person to person. It has been suggested that these individual differences in subjective valuation of delayed rewards are supported by mesolimbic dopamine D2-like receptors (D2Rs) in the ventral striatum. However, no study to date has documented an association between direct measures of dopamine receptors and neural representations of subjective value in humans. Here, we examined whether individual differences in D2R availability were related to neural subjective value signals during decision making. Human participants completed a monetary delay discounting task during an fMRI scan and on a separate visit completed a PET scan with the high affinity D2R tracer [18 F]fallypride. Region-of-interest analyses revealed that D2R availability in the ventral striatum was positively correlated with subjective value-related activity in the ventromedial prefrontal cortex and midbrain but not with choice behavior. Whole-brain analyses revealed a positive correlation between ventral striatum D2R availability and subjective value-related activity in the left inferior frontal gyrus and superior insula. These findings identify a link between a direct measure of mesolimbic dopamine function and subjective value representation in humans and suggest a mechanism by which individuals vary in neural representation of discounted subjective value.
format	article
author	Jaime J. Castrellon Jacob S. Young Linh C. Dang Ronald L. Cowan David H. Zald Gregory R. Samanez-Larkin
author_facet	Jaime J. Castrellon Jacob S. Young Linh C. Dang Ronald L. Cowan David H. Zald Gregory R. Samanez-Larkin
author_sort	Jaime J. Castrellon
title	Mesolimbic dopamine D2 receptors and neural representations of subjective value
title_short	Mesolimbic dopamine D2 receptors and neural representations of subjective value
title_full	Mesolimbic dopamine D2 receptors and neural representations of subjective value
title_fullStr	Mesolimbic dopamine D2 receptors and neural representations of subjective value
title_full_unstemmed	Mesolimbic dopamine D2 receptors and neural representations of subjective value
title_sort	mesolimbic dopamine d2 receptors and neural representations of subjective value
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9fc1ee61e58b48148c8f889cf15b9b08
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Mesolimbic dopamine D2 receptors and neural representations of subjective value

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