In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design

Antimicrobial peptides are considered promising alternatives to antibiotics. Here the authors developed a computational algorithm that starts with peptides naturally occurring in plants and optimizes this starting material to yield new variants which are highly distinct from the parent peptide.

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Detalles Bibliográficos
Autores principales: William F. Porto, Luz Irazazabal, Eliane S. F. Alves, Suzana M. Ribeiro, Carolina O. Matos, Állan S. Pires, Isabel C. M. Fensterseifer, Vivian J. Miranda, Evan F. Haney, Vincent Humblot, Marcelo D. T. Torres, Robert E. W. Hancock, Luciano M. Liao, Ali Ladram, Timothy K. Lu, Cesar de la Fuente-Nunez, Octavio L. Franco
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
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Acceso en línea:https://doaj.org/article/9fc4525fbb254412958fded74332d577
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