3D genome of multiple myeloma reveals spatial genome disorganization associated with copy number variations

Chromosome conformation capture techniques enable the study of genome organization in cancer cells. Here, the authors use Hi-C, WGS, and RNA-seq to study the 3D genome of multiple myeloma and find that genome disorganization is associated with copy number variations and changes in gene expression.

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Autores principales:	Pengze Wu, Tingting Li, Ruifeng Li, Lumeng Jia, Ping Zhu, Yifang Liu, Qing Chen, Daiwei Tang, Yuezhou Yu, Cheng Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9fc6cedb6c234ffbaeacb43e64bfc80a
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spelling	oai:doaj.org-article:9fc6cedb6c234ffbaeacb43e64bfc80a2021-12-02T17:06:15Z3D genome of multiple myeloma reveals spatial genome disorganization associated with copy number variations10.1038/s41467-017-01793-w2041-1723https://doaj.org/article/9fc6cedb6c234ffbaeacb43e64bfc80a2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01793-whttps://doaj.org/toc/2041-1723Chromosome conformation capture techniques enable the study of genome organization in cancer cells. Here, the authors use Hi-C, WGS, and RNA-seq to study the 3D genome of multiple myeloma and find that genome disorganization is associated with copy number variations and changes in gene expression.Pengze WuTingting LiRuifeng LiLumeng JiaPing ZhuYifang LiuQing ChenDaiwei TangYuezhou YuCheng LiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pengze Wu Tingting Li Ruifeng Li Lumeng Jia Ping Zhu Yifang Liu Qing Chen Daiwei Tang Yuezhou Yu Cheng Li 3D genome of multiple myeloma reveals spatial genome disorganization associated with copy number variations
description	Chromosome conformation capture techniques enable the study of genome organization in cancer cells. Here, the authors use Hi-C, WGS, and RNA-seq to study the 3D genome of multiple myeloma and find that genome disorganization is associated with copy number variations and changes in gene expression.
format	article
author	Pengze Wu Tingting Li Ruifeng Li Lumeng Jia Ping Zhu Yifang Liu Qing Chen Daiwei Tang Yuezhou Yu Cheng Li
author_facet	Pengze Wu Tingting Li Ruifeng Li Lumeng Jia Ping Zhu Yifang Liu Qing Chen Daiwei Tang Yuezhou Yu Cheng Li
author_sort	Pengze Wu
title	3D genome of multiple myeloma reveals spatial genome disorganization associated with copy number variations
title_short	3D genome of multiple myeloma reveals spatial genome disorganization associated with copy number variations
title_full	3D genome of multiple myeloma reveals spatial genome disorganization associated with copy number variations
title_fullStr	3D genome of multiple myeloma reveals spatial genome disorganization associated with copy number variations
title_full_unstemmed	3D genome of multiple myeloma reveals spatial genome disorganization associated with copy number variations
title_sort	3d genome of multiple myeloma reveals spatial genome disorganization associated with copy number variations
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9fc6cedb6c234ffbaeacb43e64bfc80a
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3D genome of multiple myeloma reveals spatial genome disorganization associated with copy number variations

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