A meta-analysis of accuracy and sensitivity of chest CT and RT-PCR in COVID-19 diagnosis

Abstract Nowadays there is an ongoing acute respiratory outbreak caused by the novel highly contagious coronavirus (COVID-19). The diagnostic protocol is based on quantitative reverse-transcription polymerase chain reaction (RT-PCR) and chests CT scan, with uncertain accuracy. This meta-analysis stu...

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Autores principales:	Fatemeh Khatami, Mohammad Saatchi, Seyed Saeed Tamehri Zadeh, Zahra Sadat Aghamir, Alireza Namazi Shabestari, Leonardo Oliveira Reis, Seyed Mohammad Kazem Aghamir
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9fc6f32583e049459bb1b9c36984cb51
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spelling	oai:doaj.org-article:9fc6f32583e049459bb1b9c36984cb512021-12-02T15:12:41ZA meta-analysis of accuracy and sensitivity of chest CT and RT-PCR in COVID-19 diagnosis10.1038/s41598-020-80061-22045-2322https://doaj.org/article/9fc6f32583e049459bb1b9c36984cb512020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80061-2https://doaj.org/toc/2045-2322Abstract Nowadays there is an ongoing acute respiratory outbreak caused by the novel highly contagious coronavirus (COVID-19). The diagnostic protocol is based on quantitative reverse-transcription polymerase chain reaction (RT-PCR) and chests CT scan, with uncertain accuracy. This meta-analysis study determines the diagnostic value of an initial chest CT scan in patients with COVID-19 infection in comparison with RT-PCR. Three main databases; PubMed (MEDLINE), Scopus, and EMBASE were systematically searched for all published literature from January 1st, 2019, to the 21st May 2020 with the keywords "COVID19 virus", "2019 novel coronavirus", "Wuhan coronavirus", "2019-nCoV", "X-Ray Computed Tomography", "Polymerase Chain Reaction", "Reverse Transcriptase PCR", and "PCR Reverse Transcriptase". All relevant case-series, cross-sectional, and cohort studies were selected. Data extraction and analysis were performed using STATA v.14.0SE (College Station, TX, USA) and RevMan 5. Among 1022 articles, 60 studies were eligible for totalizing 5744 patients. The overall sensitivity, specificity, positive predictive value, and negative predictive value of chest CT scan compared to RT-PCR were 87% (95% CI 85–90%), 46% (95% CI 29–63%), 69% (95% CI 56–72%), and 89% (95% CI 82–96%), respectively. It is important to rely on the repeated RT-PCR three times to give 99% accuracy, especially in negative samples. Regarding the overall diagnostic sensitivity of 87% for chest CT, the RT-PCR testing is essential and should be repeated to escape misdiagnosis.Fatemeh KhatamiMohammad SaatchiSeyed Saeed Tamehri ZadehZahra Sadat AghamirAlireza Namazi ShabestariLeonardo Oliveira ReisSeyed Mohammad Kazem AghamirNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fatemeh Khatami Mohammad Saatchi Seyed Saeed Tamehri Zadeh Zahra Sadat Aghamir Alireza Namazi Shabestari Leonardo Oliveira Reis Seyed Mohammad Kazem Aghamir A meta-analysis of accuracy and sensitivity of chest CT and RT-PCR in COVID-19 diagnosis
description	Abstract Nowadays there is an ongoing acute respiratory outbreak caused by the novel highly contagious coronavirus (COVID-19). The diagnostic protocol is based on quantitative reverse-transcription polymerase chain reaction (RT-PCR) and chests CT scan, with uncertain accuracy. This meta-analysis study determines the diagnostic value of an initial chest CT scan in patients with COVID-19 infection in comparison with RT-PCR. Three main databases; PubMed (MEDLINE), Scopus, and EMBASE were systematically searched for all published literature from January 1st, 2019, to the 21st May 2020 with the keywords "COVID19 virus", "2019 novel coronavirus", "Wuhan coronavirus", "2019-nCoV", "X-Ray Computed Tomography", "Polymerase Chain Reaction", "Reverse Transcriptase PCR", and "PCR Reverse Transcriptase". All relevant case-series, cross-sectional, and cohort studies were selected. Data extraction and analysis were performed using STATA v.14.0SE (College Station, TX, USA) and RevMan 5. Among 1022 articles, 60 studies were eligible for totalizing 5744 patients. The overall sensitivity, specificity, positive predictive value, and negative predictive value of chest CT scan compared to RT-PCR were 87% (95% CI 85–90%), 46% (95% CI 29–63%), 69% (95% CI 56–72%), and 89% (95% CI 82–96%), respectively. It is important to rely on the repeated RT-PCR three times to give 99% accuracy, especially in negative samples. Regarding the overall diagnostic sensitivity of 87% for chest CT, the RT-PCR testing is essential and should be repeated to escape misdiagnosis.
format	article
author	Fatemeh Khatami Mohammad Saatchi Seyed Saeed Tamehri Zadeh Zahra Sadat Aghamir Alireza Namazi Shabestari Leonardo Oliveira Reis Seyed Mohammad Kazem Aghamir
author_facet	Fatemeh Khatami Mohammad Saatchi Seyed Saeed Tamehri Zadeh Zahra Sadat Aghamir Alireza Namazi Shabestari Leonardo Oliveira Reis Seyed Mohammad Kazem Aghamir
author_sort	Fatemeh Khatami
title	A meta-analysis of accuracy and sensitivity of chest CT and RT-PCR in COVID-19 diagnosis
title_short	A meta-analysis of accuracy and sensitivity of chest CT and RT-PCR in COVID-19 diagnosis
title_full	A meta-analysis of accuracy and sensitivity of chest CT and RT-PCR in COVID-19 diagnosis
title_fullStr	A meta-analysis of accuracy and sensitivity of chest CT and RT-PCR in COVID-19 diagnosis
title_full_unstemmed	A meta-analysis of accuracy and sensitivity of chest CT and RT-PCR in COVID-19 diagnosis
title_sort	meta-analysis of accuracy and sensitivity of chest ct and rt-pcr in covid-19 diagnosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9fc6f32583e049459bb1b9c36984cb51
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A meta-analysis of accuracy and sensitivity of chest CT and RT-PCR in COVID-19 diagnosis

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