NUAK2 is a critical YAP target in liver cancer

Hippo-YAP pathway plays an important role in cancers; however the in vivo relevance of YAP/TAZ target genes is unclear. Here, the authors show that NUAK2 is a target of YAP and participates in a feedback loop to maximize YAP activity. Inhibition of NUAK2 suppresses YAP-driven hepatomegaly and liver...

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Autores principales:	Wei-Chien Yuan, Brian Pepe-Mooney, Giorgio G. Galli, Michael T. Dill, Hai-Tsang Huang, Mingfeng Hao, Yumeng Wang, Han Liang, Raffaele A. Calogero, Fernando D. Camargo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9fc9ce34002d427ca45e996eac694d2e
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spelling	oai:doaj.org-article:9fc9ce34002d427ca45e996eac694d2e2021-12-02T15:34:44ZNUAK2 is a critical YAP target in liver cancer10.1038/s41467-018-07394-52041-1723https://doaj.org/article/9fc9ce34002d427ca45e996eac694d2e2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07394-5https://doaj.org/toc/2041-1723Hippo-YAP pathway plays an important role in cancers; however the in vivo relevance of YAP/TAZ target genes is unclear. Here, the authors show that NUAK2 is a target of YAP and participates in a feedback loop to maximize YAP activity. Inhibition of NUAK2 suppresses YAP-driven hepatomegaly and liver cancer growth, offering a new target for cancer therapy.Wei-Chien YuanBrian Pepe-MooneyGiorgio G. GalliMichael T. DillHai-Tsang HuangMingfeng HaoYumeng WangHan LiangRaffaele A. CalogeroFernando D. CamargoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei-Chien Yuan Brian Pepe-Mooney Giorgio G. Galli Michael T. Dill Hai-Tsang Huang Mingfeng Hao Yumeng Wang Han Liang Raffaele A. Calogero Fernando D. Camargo NUAK2 is a critical YAP target in liver cancer
description	Hippo-YAP pathway plays an important role in cancers; however the in vivo relevance of YAP/TAZ target genes is unclear. Here, the authors show that NUAK2 is a target of YAP and participates in a feedback loop to maximize YAP activity. Inhibition of NUAK2 suppresses YAP-driven hepatomegaly and liver cancer growth, offering a new target for cancer therapy.
format	article
author	Wei-Chien Yuan Brian Pepe-Mooney Giorgio G. Galli Michael T. Dill Hai-Tsang Huang Mingfeng Hao Yumeng Wang Han Liang Raffaele A. Calogero Fernando D. Camargo
author_facet	Wei-Chien Yuan Brian Pepe-Mooney Giorgio G. Galli Michael T. Dill Hai-Tsang Huang Mingfeng Hao Yumeng Wang Han Liang Raffaele A. Calogero Fernando D. Camargo
author_sort	Wei-Chien Yuan
title	NUAK2 is a critical YAP target in liver cancer
title_short	NUAK2 is a critical YAP target in liver cancer
title_full	NUAK2 is a critical YAP target in liver cancer
title_fullStr	NUAK2 is a critical YAP target in liver cancer
title_full_unstemmed	NUAK2 is a critical YAP target in liver cancer
title_sort	nuak2 is a critical yap target in liver cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9fc9ce34002d427ca45e996eac694d2e
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_version_	1718386796348309504

NUAK2 is a critical YAP target in liver cancer

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