Herpes simplex keratitis: challenges in diagnosis and clinical management

Tayaba N Azher,1 Xiao-Tang Yin,1 Deena Tajfirouz,1 Andrew JH Huang,2 Patrick M Stuart1 1Department of Ophthalmology, Saint Louis University, 2Department of Ophthalmology and Visual Sciences, Washington University, St Louis, MO, USA Abstract: Herpes simplex virus is responsible for numerous ocular...

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Autores principales:	Azher TN, Yin X, Tajfirouz D, Huang AJH, Stuart PM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Herpes simplex virus Herpetic stromal keratitis Cornea Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/9fcc651d2b8e44238ecd8f65ad0e9efc
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spelling	oai:doaj.org-article:9fcc651d2b8e44238ecd8f65ad0e9efc2021-12-02T01:18:00ZHerpes simplex keratitis: challenges in diagnosis and clinical management1177-5483https://doaj.org/article/9fcc651d2b8e44238ecd8f65ad0e9efc2017-01-01T00:00:00Zhttps://www.dovepress.com/herpes-simplex-keratitis-challenges-in-diagnosis-and-clinical-manageme-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Tayaba N Azher,1 Xiao-Tang Yin,1 Deena Tajfirouz,1 Andrew JH Huang,2 Patrick M Stuart1 1Department of Ophthalmology, Saint Louis University, 2Department of Ophthalmology and Visual Sciences, Washington University, St Louis, MO, USA Abstract: Herpes simplex virus is responsible for numerous ocular diseases, the most common of which is herpetic stromal keratitis. This is a recurrent infection of the cornea that typically begins with a subclinical infection of the cornea that establishes a latent infection of sensory ganglia, most often the trigeminal ganglia. Recurring infections occur when the virus is reactivated from latency and travels back to the cornea, where it restimulates an inflammatory response. This inflammatory response can lead to decreased corneal sensation, scarring, and blindness. The diagnosis of these lesions as the result of a recurrent herpes simplex virus infection can at times be problematic. Currently, herpetic stromal keratitis is diagnosed by its clinical presentation on the slit-lamp examination, but the literature does not always support the accuracy of these clinical findings. Other diagnostic tests such as polymerase chain reaction assay, enzyme-linked immunosorbent assay, immunofluorescent antibody, and viral cultures have provided more definitive diagnosis, but also have some limitations. That said, accurate diagnosis is necessary for proper treatment, in order to prevent serious consequences. Current treatment reduces the severity of lesions and controls further viral spread, but does not provide a cure. Keywords: herpes simplex virus, herpetic stromal keratitis, corneaAzher TNYin XTajfirouz DHuang AJHStuart PMDove Medical PressarticleHerpes simplex virus Herpetic stromal keratitis CorneaOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 185-191 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Herpes simplex virus Herpetic stromal keratitis Cornea Ophthalmology RE1-994
spellingShingle	Herpes simplex virus Herpetic stromal keratitis Cornea Ophthalmology RE1-994 Azher TN Yin X Tajfirouz D Huang AJH Stuart PM Herpes simplex keratitis: challenges in diagnosis and clinical management
description	Tayaba N Azher,1 Xiao-Tang Yin,1 Deena Tajfirouz,1 Andrew JH Huang,2 Patrick M Stuart1 1Department of Ophthalmology, Saint Louis University, 2Department of Ophthalmology and Visual Sciences, Washington University, St Louis, MO, USA Abstract: Herpes simplex virus is responsible for numerous ocular diseases, the most common of which is herpetic stromal keratitis. This is a recurrent infection of the cornea that typically begins with a subclinical infection of the cornea that establishes a latent infection of sensory ganglia, most often the trigeminal ganglia. Recurring infections occur when the virus is reactivated from latency and travels back to the cornea, where it restimulates an inflammatory response. This inflammatory response can lead to decreased corneal sensation, scarring, and blindness. The diagnosis of these lesions as the result of a recurrent herpes simplex virus infection can at times be problematic. Currently, herpetic stromal keratitis is diagnosed by its clinical presentation on the slit-lamp examination, but the literature does not always support the accuracy of these clinical findings. Other diagnostic tests such as polymerase chain reaction assay, enzyme-linked immunosorbent assay, immunofluorescent antibody, and viral cultures have provided more definitive diagnosis, but also have some limitations. That said, accurate diagnosis is necessary for proper treatment, in order to prevent serious consequences. Current treatment reduces the severity of lesions and controls further viral spread, but does not provide a cure. Keywords: herpes simplex virus, herpetic stromal keratitis, cornea
format	article
author	Azher TN Yin X Tajfirouz D Huang AJH Stuart PM
author_facet	Azher TN Yin X Tajfirouz D Huang AJH Stuart PM
author_sort	Azher TN
title	Herpes simplex keratitis: challenges in diagnosis and clinical management
title_short	Herpes simplex keratitis: challenges in diagnosis and clinical management
title_full	Herpes simplex keratitis: challenges in diagnosis and clinical management
title_fullStr	Herpes simplex keratitis: challenges in diagnosis and clinical management
title_full_unstemmed	Herpes simplex keratitis: challenges in diagnosis and clinical management
title_sort	herpes simplex keratitis: challenges in diagnosis and clinical management
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/9fcc651d2b8e44238ecd8f65ad0e9efc
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Herpes simplex keratitis: challenges in diagnosis and clinical management

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