Kidney Injury in Children Infected with HIV, Followed at the Teaching Hospital of Borgou (Benin): Epidemiological and Clinical Aspects

The history of kidney disease associated with HIV infection dates back to the years of HIV breakthrough. The objective was to study kidney damage in children infected with HIV at the Teaching Hospital of Borgou (Benin) in 2019. This was a cross-sectional, descriptive, analytical, matching-type stud...

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Autores principales:	Séraphin Ahoui, Falilatou Agbeille, Gerard Kpanidja, Alphonse Noudamadjo, Muriel Fridzie Toutche, Bruno Leopold Agboton, Evariste Eteka, Jacques Vigan, Adedemy Julien Didier, Joseph Agossou
Formato:	article
Lenguaje:	EN
Publicado:	Codon Publications 2021
Materias:	Benin HIV-positive kidney disease pediatrics Diseases of the endocrine glands. Clinical endocrinology RC648-665 Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/9fd0b717b4c9467ea0cacdef6b42d6ab
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spelling	oai:doaj.org-article:9fd0b717b4c9467ea0cacdef6b42d6ab2021-11-17T03:55:03ZKidney Injury in Children Infected with HIV, Followed at the Teaching Hospital of Borgou (Benin): Epidemiological and Clinical Aspects10.15586/jrenhep.v5i2.1202207-3744https://doaj.org/article/9fd0b717b4c9467ea0cacdef6b42d6ab2021-10-01T00:00:00Zhttps://jrenhep.com/index.php/jrenhep/article/view/120https://doaj.org/toc/2207-3744 The history of kidney disease associated with HIV infection dates back to the years of HIV breakthrough. The objective was to study kidney damage in children infected with HIV at the Teaching Hospital of Borgou (Benin) in 2019. This was a cross-sectional, descriptive, analytical, matching-type study carried out from June 1, 2019 to September 30, 2019 at the pediatrics department of Teaching Hospital of Borgou (Benin). The study included HIV-positive children, followed in consultations, and whose parents gave their consent. The biological markers were demonstrated with urine dipstick. Glomerular filtration rate was calculated using the Schwartz test and classified according to stages. The dependent variable was the presence of at least one impairment (biological or functional). Sample size was determined by Schwartz’s method on the basis of one case for two controls. Sociodemographic, clinical, biological, and therapeutic data were collected. Comparisons were made using the Chi- square test or Fisher’s exact test. The identification of associated factors was possible using a multiple logistic regression model at 5% threshold. In total, we included 117 children, including 39 HIV-positive children. The average age was 8 ± 4.81 years and the gender ratio was 1:17. The frequency of kidney damage was 76.5%. Permanent proteinuria and at least two crosses on urine dipstick were present in 20.5%, leukocyturia in 2.6%, and proximal tubular dysfunction in 5.1%. Glomerular hyperfiltration was found in 38.5%, acute kidney injury in 38.5%, and chronic kidney injury in 5.1%. Associated factors were age (P = 0.004), presence of opportunistic infections (P = 0.00), and treatment adherence (P = 0.004). Kidney damage is common in HIV-positive children. Careful follow-up is necessary to avoid complications. Séraphin AhouiFalilatou AgbeilleGerard KpanidjaAlphonse NoudamadjoMuriel Fridzie ToutcheBruno Leopold AgbotonEvariste EtekaJacques ViganAdedemy Julien DidierJoseph AgossouCodon PublicationsarticleBeninHIV-positivekidney diseasepediatricsDiseases of the endocrine glands. Clinical endocrinologyRC648-665Diseases of the genitourinary system. UrologyRC870-923ENJournal of Renal and Hepatic Disorders, Vol 5, Iss 2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Benin HIV-positive kidney disease pediatrics Diseases of the endocrine glands. Clinical endocrinology RC648-665 Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Benin HIV-positive kidney disease pediatrics Diseases of the endocrine glands. Clinical endocrinology RC648-665 Diseases of the genitourinary system. Urology RC870-923 Séraphin Ahoui Falilatou Agbeille Gerard Kpanidja Alphonse Noudamadjo Muriel Fridzie Toutche Bruno Leopold Agboton Evariste Eteka Jacques Vigan Adedemy Julien Didier Joseph Agossou Kidney Injury in Children Infected with HIV, Followed at the Teaching Hospital of Borgou (Benin): Epidemiological and Clinical Aspects
description	The history of kidney disease associated with HIV infection dates back to the years of HIV breakthrough. The objective was to study kidney damage in children infected with HIV at the Teaching Hospital of Borgou (Benin) in 2019. This was a cross-sectional, descriptive, analytical, matching-type study carried out from June 1, 2019 to September 30, 2019 at the pediatrics department of Teaching Hospital of Borgou (Benin). The study included HIV-positive children, followed in consultations, and whose parents gave their consent. The biological markers were demonstrated with urine dipstick. Glomerular filtration rate was calculated using the Schwartz test and classified according to stages. The dependent variable was the presence of at least one impairment (biological or functional). Sample size was determined by Schwartz’s method on the basis of one case for two controls. Sociodemographic, clinical, biological, and therapeutic data were collected. Comparisons were made using the Chi- square test or Fisher’s exact test. The identification of associated factors was possible using a multiple logistic regression model at 5% threshold. In total, we included 117 children, including 39 HIV-positive children. The average age was 8 ± 4.81 years and the gender ratio was 1:17. The frequency of kidney damage was 76.5%. Permanent proteinuria and at least two crosses on urine dipstick were present in 20.5%, leukocyturia in 2.6%, and proximal tubular dysfunction in 5.1%. Glomerular hyperfiltration was found in 38.5%, acute kidney injury in 38.5%, and chronic kidney injury in 5.1%. Associated factors were age (P = 0.004), presence of opportunistic infections (P = 0.00), and treatment adherence (P = 0.004). Kidney damage is common in HIV-positive children. Careful follow-up is necessary to avoid complications.
format	article
author	Séraphin Ahoui Falilatou Agbeille Gerard Kpanidja Alphonse Noudamadjo Muriel Fridzie Toutche Bruno Leopold Agboton Evariste Eteka Jacques Vigan Adedemy Julien Didier Joseph Agossou
author_facet	Séraphin Ahoui Falilatou Agbeille Gerard Kpanidja Alphonse Noudamadjo Muriel Fridzie Toutche Bruno Leopold Agboton Evariste Eteka Jacques Vigan Adedemy Julien Didier Joseph Agossou
author_sort	Séraphin Ahoui
title	Kidney Injury in Children Infected with HIV, Followed at the Teaching Hospital of Borgou (Benin): Epidemiological and Clinical Aspects
title_short	Kidney Injury in Children Infected with HIV, Followed at the Teaching Hospital of Borgou (Benin): Epidemiological and Clinical Aspects
title_full	Kidney Injury in Children Infected with HIV, Followed at the Teaching Hospital of Borgou (Benin): Epidemiological and Clinical Aspects
title_fullStr	Kidney Injury in Children Infected with HIV, Followed at the Teaching Hospital of Borgou (Benin): Epidemiological and Clinical Aspects
title_full_unstemmed	Kidney Injury in Children Infected with HIV, Followed at the Teaching Hospital of Borgou (Benin): Epidemiological and Clinical Aspects
title_sort	kidney injury in children infected with hiv, followed at the teaching hospital of borgou (benin): epidemiological and clinical aspects
publisher	Codon Publications
publishDate	2021
url	https://doaj.org/article/9fd0b717b4c9467ea0cacdef6b42d6ab
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Kidney Injury in Children Infected with HIV, Followed at the Teaching Hospital of Borgou (Benin): Epidemiological and Clinical Aspects

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