Helix 8 is the essential structural motif of mechanosensitive GPCRs

Helix 8 is the essential structural motif of mechanosensitive GPCRs

GPCRs are versatile cellular sensors for chemical stimuli but the molecular mechanisms underlying mechanically induced GPCR activation have remained elusive. Here authors identify the C-terminal helix 8 (H8) as the essential structural motif endowing H1R and other GPCRs with mechanosensitivity.

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Auteurs principaux: Serap Erdogmus, Ursula Storch, Laura Danner, Jasmin Becker, Michaela Winter, Nicole Ziegler, Angela Wirth, Stefan Offermanns, Carsten Hoffmann, Thomas Gudermann, Michael Mederos y Schnitzler
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Science
Q
Accès en ligne:https://doaj.org/article/9fd1442d78534dbea5f8633d29b4f407
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spelling oai:doaj.org-article:9fd1442d78534dbea5f8633d29b4f4072021-12-02T15:36:22ZHelix 8 is the essential structural motif of mechanosensitive GPCRs10.1038/s41467-019-13722-02041-1723https://doaj.org/article/9fd1442d78534dbea5f8633d29b4f4072019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13722-0https://doaj.org/toc/2041-1723GPCRs are versatile cellular sensors for chemical stimuli but the molecular mechanisms underlying mechanically induced GPCR activation have remained elusive. Here authors identify the C-terminal helix 8 (H8) as the essential structural motif endowing H1R and other GPCRs with mechanosensitivity.Serap ErdogmusUrsula StorchLaura DannerJasmin BeckerMichaela WinterNicole ZieglerAngela WirthStefan OffermannsCarsten HoffmannThomas GudermannMichael Mederos y SchnitzlerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Serap Erdogmus
Ursula Storch
Laura Danner
Jasmin Becker
Michaela Winter
Nicole Ziegler
Angela Wirth
Stefan Offermanns
Carsten Hoffmann
Thomas Gudermann
Michael Mederos y Schnitzler
Helix 8 is the essential structural motif of mechanosensitive GPCRs
description GPCRs are versatile cellular sensors for chemical stimuli but the molecular mechanisms underlying mechanically induced GPCR activation have remained elusive. Here authors identify the C-terminal helix 8 (H8) as the essential structural motif endowing H1R and other GPCRs with mechanosensitivity.
format article
author Serap Erdogmus
Ursula Storch
Laura Danner
Jasmin Becker
Michaela Winter
Nicole Ziegler
Angela Wirth
Stefan Offermanns
Carsten Hoffmann
Thomas Gudermann
Michael Mederos y Schnitzler
author_facet Serap Erdogmus
Ursula Storch
Laura Danner
Jasmin Becker
Michaela Winter
Nicole Ziegler
Angela Wirth
Stefan Offermanns
Carsten Hoffmann
Thomas Gudermann
Michael Mederos y Schnitzler
author_sort Serap Erdogmus
title Helix 8 is the essential structural motif of mechanosensitive GPCRs
title_short Helix 8 is the essential structural motif of mechanosensitive GPCRs
title_full Helix 8 is the essential structural motif of mechanosensitive GPCRs
title_fullStr Helix 8 is the essential structural motif of mechanosensitive GPCRs
title_full_unstemmed Helix 8 is the essential structural motif of mechanosensitive GPCRs
title_sort helix 8 is the essential structural motif of mechanosensitive gpcrs
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/9fd1442d78534dbea5f8633d29b4f407
work_keys_str_mv AT seraperdogmus helix8istheessentialstructuralmotifofmechanosensitivegpcrs
AT ursulastorch helix8istheessentialstructuralmotifofmechanosensitivegpcrs
AT lauradanner helix8istheessentialstructuralmotifofmechanosensitivegpcrs
AT jasminbecker helix8istheessentialstructuralmotifofmechanosensitivegpcrs
AT michaelawinter helix8istheessentialstructuralmotifofmechanosensitivegpcrs
AT nicoleziegler helix8istheessentialstructuralmotifofmechanosensitivegpcrs
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AT stefanoffermanns helix8istheessentialstructuralmotifofmechanosensitivegpcrs
AT carstenhoffmann helix8istheessentialstructuralmotifofmechanosensitivegpcrs
AT thomasgudermann helix8istheessentialstructuralmotifofmechanosensitivegpcrs
AT michaelmederosyschnitzler helix8istheessentialstructuralmotifofmechanosensitivegpcrs
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