Helix 8 is the essential structural motif of mechanosensitive GPCRs

GPCRs are versatile cellular sensors for chemical stimuli but the molecular mechanisms underlying mechanically induced GPCR activation have remained elusive. Here authors identify the C-terminal helix 8 (H8) as the essential structural motif endowing H1R and other GPCRs with mechanosensitivity.

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Autores principales:	Serap Erdogmus, Ursula Storch, Laura Danner, Jasmin Becker, Michaela Winter, Nicole Ziegler, Angela Wirth, Stefan Offermanns, Carsten Hoffmann, Thomas Gudermann, Michael Mederos y Schnitzler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9fd1442d78534dbea5f8633d29b4f407
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spelling	oai:doaj.org-article:9fd1442d78534dbea5f8633d29b4f4072021-12-02T15:36:22ZHelix 8 is the essential structural motif of mechanosensitive GPCRs10.1038/s41467-019-13722-02041-1723https://doaj.org/article/9fd1442d78534dbea5f8633d29b4f4072019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13722-0https://doaj.org/toc/2041-1723GPCRs are versatile cellular sensors for chemical stimuli but the molecular mechanisms underlying mechanically induced GPCR activation have remained elusive. Here authors identify the C-terminal helix 8 (H8) as the essential structural motif endowing H1R and other GPCRs with mechanosensitivity.Serap ErdogmusUrsula StorchLaura DannerJasmin BeckerMichaela WinterNicole ZieglerAngela WirthStefan OffermannsCarsten HoffmannThomas GudermannMichael Mederos y SchnitzlerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Serap Erdogmus Ursula Storch Laura Danner Jasmin Becker Michaela Winter Nicole Ziegler Angela Wirth Stefan Offermanns Carsten Hoffmann Thomas Gudermann Michael Mederos y Schnitzler Helix 8 is the essential structural motif of mechanosensitive GPCRs
description	GPCRs are versatile cellular sensors for chemical stimuli but the molecular mechanisms underlying mechanically induced GPCR activation have remained elusive. Here authors identify the C-terminal helix 8 (H8) as the essential structural motif endowing H1R and other GPCRs with mechanosensitivity.
format	article
author	Serap Erdogmus Ursula Storch Laura Danner Jasmin Becker Michaela Winter Nicole Ziegler Angela Wirth Stefan Offermanns Carsten Hoffmann Thomas Gudermann Michael Mederos y Schnitzler
author_facet	Serap Erdogmus Ursula Storch Laura Danner Jasmin Becker Michaela Winter Nicole Ziegler Angela Wirth Stefan Offermanns Carsten Hoffmann Thomas Gudermann Michael Mederos y Schnitzler
author_sort	Serap Erdogmus
title	Helix 8 is the essential structural motif of mechanosensitive GPCRs
title_short	Helix 8 is the essential structural motif of mechanosensitive GPCRs
title_full	Helix 8 is the essential structural motif of mechanosensitive GPCRs
title_fullStr	Helix 8 is the essential structural motif of mechanosensitive GPCRs
title_full_unstemmed	Helix 8 is the essential structural motif of mechanosensitive GPCRs
title_sort	helix 8 is the essential structural motif of mechanosensitive gpcrs
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9fd1442d78534dbea5f8633d29b4f407
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Helix 8 is the essential structural motif of mechanosensitive GPCRs

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