Helix 8 is the essential structural motif of mechanosensitive GPCRs

Helix 8 is the essential structural motif of mechanosensitive GPCRs

GPCRs are versatile cellular sensors for chemical stimuli but the molecular mechanisms underlying mechanically induced GPCR activation have remained elusive. Here authors identify the C-terminal helix 8 (H8) as the essential structural motif endowing H1R and other GPCRs with mechanosensitivity.

Saved in:
Bibliographic Details
Main Authors: Serap Erdogmus, Ursula Storch, Laura Danner, Jasmin Becker, Michaela Winter, Nicole Ziegler, Angela Wirth, Stefan Offermanns, Carsten Hoffmann, Thomas Gudermann, Michael Mederos y Schnitzler
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
Q
Online Access:https://doaj.org/article/9fd1442d78534dbea5f8633d29b4f407
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/9fd1442d78534dbea5f8633d29b4f407

Similar Items