Advances in 3D peptide hydrogel models in cancer research

Abstract In vitro cell culture models on monolayer surfaces (2D) have been widely adapted for identification of chemopreventive food compounds and food safety evaluation. However, the low correlation between 2D models and in vivo animal models has always been a concern; this gap is mainly caused by...

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Autores principales:	Jingwen Xu, Guangyan Qi, Weiqun Wang, Xiuzhi Susan Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Nutrition. Foods and food supply TX341-641 Food processing and manufacture TP368-456
Acceso en línea:	https://doaj.org/article/9fd4436a418142b4a8c1ac39ae78dcab
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spelling	oai:doaj.org-article:9fd4436a418142b4a8c1ac39ae78dcab2021-12-02T15:02:30ZAdvances in 3D peptide hydrogel models in cancer research10.1038/s41538-021-00096-12396-8370https://doaj.org/article/9fd4436a418142b4a8c1ac39ae78dcab2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41538-021-00096-1https://doaj.org/toc/2396-8370Abstract In vitro cell culture models on monolayer surfaces (2D) have been widely adapted for identification of chemopreventive food compounds and food safety evaluation. However, the low correlation between 2D models and in vivo animal models has always been a concern; this gap is mainly caused by the lack of a three-dimensional (3D) extracellular microenvironment. In 2D models, cell behaviors and functionalities are altered, resulting in varied responses to external conditions (i.e., antioxidants) and hence leading to low predictability. Peptide hydrogel 3D scaffolding technologies, such as PGmatrix for cell culture, have been recently reported to grow organoid-like spheroids physiologically mimicking the 3D microenvironment that can be used as an in vitro 3D model for investigating cell activities, which is anticipated to improve the prediction rate. Thus, this review focuses on advances in 3D peptide hydrogels aiming to introduce 3D cell culture tools as in vitro 3D models for cancer-related research regarding food safety and nutraceuticals.Jingwen XuGuangyan QiWeiqun WangXiuzhi Susan SunNature PortfolioarticleNutrition. Foods and food supplyTX341-641Food processing and manufactureTP368-456ENnpj Science of Food, Vol 5, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nutrition. Foods and food supply TX341-641 Food processing and manufacture TP368-456
spellingShingle	Nutrition. Foods and food supply TX341-641 Food processing and manufacture TP368-456 Jingwen Xu Guangyan Qi Weiqun Wang Xiuzhi Susan Sun Advances in 3D peptide hydrogel models in cancer research
description	Abstract In vitro cell culture models on monolayer surfaces (2D) have been widely adapted for identification of chemopreventive food compounds and food safety evaluation. However, the low correlation between 2D models and in vivo animal models has always been a concern; this gap is mainly caused by the lack of a three-dimensional (3D) extracellular microenvironment. In 2D models, cell behaviors and functionalities are altered, resulting in varied responses to external conditions (i.e., antioxidants) and hence leading to low predictability. Peptide hydrogel 3D scaffolding technologies, such as PGmatrix for cell culture, have been recently reported to grow organoid-like spheroids physiologically mimicking the 3D microenvironment that can be used as an in vitro 3D model for investigating cell activities, which is anticipated to improve the prediction rate. Thus, this review focuses on advances in 3D peptide hydrogels aiming to introduce 3D cell culture tools as in vitro 3D models for cancer-related research regarding food safety and nutraceuticals.
format	article
author	Jingwen Xu Guangyan Qi Weiqun Wang Xiuzhi Susan Sun
author_facet	Jingwen Xu Guangyan Qi Weiqun Wang Xiuzhi Susan Sun
author_sort	Jingwen Xu
title	Advances in 3D peptide hydrogel models in cancer research
title_short	Advances in 3D peptide hydrogel models in cancer research
title_full	Advances in 3D peptide hydrogel models in cancer research
title_fullStr	Advances in 3D peptide hydrogel models in cancer research
title_full_unstemmed	Advances in 3D peptide hydrogel models in cancer research
title_sort	advances in 3d peptide hydrogel models in cancer research
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9fd4436a418142b4a8c1ac39ae78dcab
work_keys_str_mv	AT jingwenxu advancesin3dpeptidehydrogelmodelsincancerresearch AT guangyanqi advancesin3dpeptidehydrogelmodelsincancerresearch AT weiqunwang advancesin3dpeptidehydrogelmodelsincancerresearch AT xiuzhisusansun advancesin3dpeptidehydrogelmodelsincancerresearch
_version_	1718389093406081024

Advances in 3D peptide hydrogel models in cancer research

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