A predictable conserved DNA base composition signature defines human core DNA replication origins

In metazoan the DNA sequence elements characterizing origin specification are unknown. By generating and analysing 19 SNS-seq datasets from different human cell types, the authors reveal a class and features of Core origins of replication which can be predicted by an algorithm.

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Autores principales:	Ildem Akerman, Bahar Kasaai, Alina Bazarova, Pau Biak Sang, Isabelle Peiffer, Marie Artufel, Romain Derelle, Gabrielle Smith, Marta Rodriguez-Martinez, Manuela Romano, Sandrina Kinet, Peter Tino, Charles Theillet, Naomi Taylor, Benoit Ballester, Marcel Méchali
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9fd4abfa0458400da994ba8ead8f7cae
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spelling	oai:doaj.org-article:9fd4abfa0458400da994ba8ead8f7cae2021-12-02T18:14:41ZA predictable conserved DNA base composition signature defines human core DNA replication origins10.1038/s41467-020-18527-02041-1723https://doaj.org/article/9fd4abfa0458400da994ba8ead8f7cae2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18527-0https://doaj.org/toc/2041-1723In metazoan the DNA sequence elements characterizing origin specification are unknown. By generating and analysing 19 SNS-seq datasets from different human cell types, the authors reveal a class and features of Core origins of replication which can be predicted by an algorithm.Ildem AkermanBahar KasaaiAlina BazarovaPau Biak SangIsabelle PeifferMarie ArtufelRomain DerelleGabrielle SmithMarta Rodriguez-MartinezManuela RomanoSandrina KinetPeter TinoCharles TheilletNaomi TaylorBenoit BallesterMarcel MéchaliNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ildem Akerman Bahar Kasaai Alina Bazarova Pau Biak Sang Isabelle Peiffer Marie Artufel Romain Derelle Gabrielle Smith Marta Rodriguez-Martinez Manuela Romano Sandrina Kinet Peter Tino Charles Theillet Naomi Taylor Benoit Ballester Marcel Méchali A predictable conserved DNA base composition signature defines human core DNA replication origins
description	In metazoan the DNA sequence elements characterizing origin specification are unknown. By generating and analysing 19 SNS-seq datasets from different human cell types, the authors reveal a class and features of Core origins of replication which can be predicted by an algorithm.
format	article
author	Ildem Akerman Bahar Kasaai Alina Bazarova Pau Biak Sang Isabelle Peiffer Marie Artufel Romain Derelle Gabrielle Smith Marta Rodriguez-Martinez Manuela Romano Sandrina Kinet Peter Tino Charles Theillet Naomi Taylor Benoit Ballester Marcel Méchali
author_facet	Ildem Akerman Bahar Kasaai Alina Bazarova Pau Biak Sang Isabelle Peiffer Marie Artufel Romain Derelle Gabrielle Smith Marta Rodriguez-Martinez Manuela Romano Sandrina Kinet Peter Tino Charles Theillet Naomi Taylor Benoit Ballester Marcel Méchali
author_sort	Ildem Akerman
title	A predictable conserved DNA base composition signature defines human core DNA replication origins
title_short	A predictable conserved DNA base composition signature defines human core DNA replication origins
title_full	A predictable conserved DNA base composition signature defines human core DNA replication origins
title_fullStr	A predictable conserved DNA base composition signature defines human core DNA replication origins
title_full_unstemmed	A predictable conserved DNA base composition signature defines human core DNA replication origins
title_sort	predictable conserved dna base composition signature defines human core dna replication origins
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9fd4abfa0458400da994ba8ead8f7cae
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A predictable conserved DNA base composition signature defines human core DNA replication origins

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