Fixed combination of travoprost and timolol maleate reduces intraocular pressure in Japanese patients with primary open-angle glaucoma or ocular hypertension: analysis by prostaglandin analogue

Tadashi Nakano,1 Shiro Mizoue,2 Nobuo Fuse,3 Aiko Iwase,4 Shun Matsumoto,5 Keiji Yoshikawa6 On behalf of the I.CHANGE2 study group 1Department of Ophthalmology, The Jikei University School of Medicine, Nishi-Shimbashi, Minato-ku, Tokyo, 2Department of Ophthalmology, Ehime University Graduate Scho...

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Autores principales:	Nakano T, Mizoue S, Fuse N, Iwase A, Matsumoto S, Yoshikawa K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	adverse event intraocular pressure prostaglandin analog switching therapy travoprost/timolol fixed combination　 Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/9fd585c453a741dd991436fedbe8e671
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spelling	oai:doaj.org-article:9fd585c453a741dd991436fedbe8e6712021-12-02T00:52:35ZFixed combination of travoprost and timolol maleate reduces intraocular pressure in Japanese patients with primary open-angle glaucoma or ocular hypertension: analysis by prostaglandin analogue1177-5483https://doaj.org/article/9fd585c453a741dd991436fedbe8e6712016-12-01T00:00:00Zhttps://www.dovepress.com/fixed-combination-of-travoprost-and-timolol-maleate-reduces-intraocula-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Tadashi Nakano,1 Shiro Mizoue,2 Nobuo Fuse,3 Aiko Iwase,4 Shun Matsumoto,5 Keiji Yoshikawa6 On behalf of the I.CHANGE2 study group 1Department of Ophthalmology, The Jikei University School of Medicine, Nishi-Shimbashi, Minato-ku, Tokyo, 2Department of Ophthalmology, Ehime University Graduate School of Medicine, Shitsukawa, Toon-city, Ehime, 3Department of Integrative Genomics, Tohoku Medical Megabank Organization, Seiryo-machi, Sendai, Miyagi, 4Tajimi Iwase Eye Clinic, Hon-machi, Tajimi, Gifu, 5Department of Ophthalmology, Tokyo Teishin Hospital, Fujimi, Chiyoda-ku, 6Yoshikawa Eye Clinic, Naka-machi, Machida, Tokyo, Japan Background: We have shown a decrease in mean intraocular pressure (IOP) by switching to travoprost/timolol fixed combination (TTFC) in subjects receiving prostaglandin analogue (PGA) monotherapy and requiring additional medication in a previous report. For analyzing factors affecting IOP reduction, baseline IOP and preceding PGA were selected as statistically and clinically significant factors. In this report, we examine IOP-lowering effect and adverse drug reactions by preceding PGA.Methods: Patients with primary open angle glaucoma or ocular hypertension who received monotherapy with one of four PGAs (travoprost, latanoprost, tafluprost, or bimatoprost) for at least 3 months at 26 institutions and were determined to require additional medication by their primary physician were included. IOP reduction and adverse events were examined at 4, 8, and 12 weeks for each of four PGAs after switching to TTFC.Results: In total, 157 patients who could be followed up for at least 4 weeks after switching to TTFC were included in the efficacy analysis. Multiple regression analysis was performed, and baseline IOP and PGA were found to be significant factors to IOP reduction. IOP reduction at week 12, adjusted with the regression model, was -3.5, -1.8, and -1.4 mmHg in the tafluprost, latanoprost, and travoprost groups, whereas it was -0.5 mmHg in the bimatoprost group. Along with differences in baseline IOP between groups, an IOP-lowering effect of >1 mmHg was noted in the tafluprost, latanoprost, and travoprost groups after the switch. IOP was maintained at 13.8–14.8 mmHg throughout the follow-up period. No serious adverse events or noteworthy issues were observed in any group after the switch.Conclusion: Clinically significant IOP-reducing effects of TTFC were observed in the latanoprost, travoprost, and tafluprost groups when switching from each PGA monotherapy, while there were some differences in effects between groups, with minimal safety concerns. Keywords: adverse event intraocular pressure, prostaglandin analogue, switching therapy, travoprost/timolol fixed combinationNakano TMizoue SFuse NIwase AMatsumoto SYoshikawa KDove Medical Pressarticleadverse event intraocular pressureprostaglandin analogswitching therapytravoprost/timolol fixed combination　OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 55-61 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	adverse event intraocular pressure prostaglandin analog switching therapy travoprost/timolol fixed combination　 Ophthalmology RE1-994
spellingShingle	adverse event intraocular pressure prostaglandin analog switching therapy travoprost/timolol fixed combination　 Ophthalmology RE1-994 Nakano T Mizoue S Fuse N Iwase A Matsumoto S Yoshikawa K Fixed combination of travoprost and timolol maleate reduces intraocular pressure in Japanese patients with primary open-angle glaucoma or ocular hypertension: analysis by prostaglandin analogue
description	Tadashi Nakano,1 Shiro Mizoue,2 Nobuo Fuse,3 Aiko Iwase,4 Shun Matsumoto,5 Keiji Yoshikawa6 On behalf of the I.CHANGE2 study group 1Department of Ophthalmology, The Jikei University School of Medicine, Nishi-Shimbashi, Minato-ku, Tokyo, 2Department of Ophthalmology, Ehime University Graduate School of Medicine, Shitsukawa, Toon-city, Ehime, 3Department of Integrative Genomics, Tohoku Medical Megabank Organization, Seiryo-machi, Sendai, Miyagi, 4Tajimi Iwase Eye Clinic, Hon-machi, Tajimi, Gifu, 5Department of Ophthalmology, Tokyo Teishin Hospital, Fujimi, Chiyoda-ku, 6Yoshikawa Eye Clinic, Naka-machi, Machida, Tokyo, Japan Background: We have shown a decrease in mean intraocular pressure (IOP) by switching to travoprost/timolol fixed combination (TTFC) in subjects receiving prostaglandin analogue (PGA) monotherapy and requiring additional medication in a previous report. For analyzing factors affecting IOP reduction, baseline IOP and preceding PGA were selected as statistically and clinically significant factors. In this report, we examine IOP-lowering effect and adverse drug reactions by preceding PGA.Methods: Patients with primary open angle glaucoma or ocular hypertension who received monotherapy with one of four PGAs (travoprost, latanoprost, tafluprost, or bimatoprost) for at least 3 months at 26 institutions and were determined to require additional medication by their primary physician were included. IOP reduction and adverse events were examined at 4, 8, and 12 weeks for each of four PGAs after switching to TTFC.Results: In total, 157 patients who could be followed up for at least 4 weeks after switching to TTFC were included in the efficacy analysis. Multiple regression analysis was performed, and baseline IOP and PGA were found to be significant factors to IOP reduction. IOP reduction at week 12, adjusted with the regression model, was -3.5, -1.8, and -1.4 mmHg in the tafluprost, latanoprost, and travoprost groups, whereas it was -0.5 mmHg in the bimatoprost group. Along with differences in baseline IOP between groups, an IOP-lowering effect of >1 mmHg was noted in the tafluprost, latanoprost, and travoprost groups after the switch. IOP was maintained at 13.8–14.8 mmHg throughout the follow-up period. No serious adverse events or noteworthy issues were observed in any group after the switch.Conclusion: Clinically significant IOP-reducing effects of TTFC were observed in the latanoprost, travoprost, and tafluprost groups when switching from each PGA monotherapy, while there were some differences in effects between groups, with minimal safety concerns. Keywords: adverse event intraocular pressure, prostaglandin analogue, switching therapy, travoprost/timolol fixed combination
format	article
author	Nakano T Mizoue S Fuse N Iwase A Matsumoto S Yoshikawa K
author_facet	Nakano T Mizoue S Fuse N Iwase A Matsumoto S Yoshikawa K
author_sort	Nakano T
title	Fixed combination of travoprost and timolol maleate reduces intraocular pressure in Japanese patients with primary open-angle glaucoma or ocular hypertension: analysis by prostaglandin analogue
title_short	Fixed combination of travoprost and timolol maleate reduces intraocular pressure in Japanese patients with primary open-angle glaucoma or ocular hypertension: analysis by prostaglandin analogue
title_full	Fixed combination of travoprost and timolol maleate reduces intraocular pressure in Japanese patients with primary open-angle glaucoma or ocular hypertension: analysis by prostaglandin analogue
title_fullStr	Fixed combination of travoprost and timolol maleate reduces intraocular pressure in Japanese patients with primary open-angle glaucoma or ocular hypertension: analysis by prostaglandin analogue
title_full_unstemmed	Fixed combination of travoprost and timolol maleate reduces intraocular pressure in Japanese patients with primary open-angle glaucoma or ocular hypertension: analysis by prostaglandin analogue
title_sort	fixed combination of travoprost and timolol maleate reduces intraocular pressure in japanese patients with primary open-angle glaucoma or ocular hypertension: analysis by prostaglandin analogue
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/9fd585c453a741dd991436fedbe8e671
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Fixed combination of travoprost and timolol maleate reduces intraocular pressure in Japanese patients with primary open-angle glaucoma or ocular hypertension: analysis by prostaglandin analogue

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