Rheumatic heart disease in pregnancy and neonatal outcomes: A systematic review and meta-analysis.

<h4>Purpose</h4>Associations between rheumatic heart disease (RHD) in pregnancy and fetal outcomes are relatively unknown. This study aimed to review rates and predictors of major adverse fetal outcomes of RHD in pregnancy.<h4>Methods</h4>Medline (Ovid), Pubmed, EMcare, Scopu...

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Autores principales: Joshua Liaw, Betrice Walker, Leanne Hall, Susan Gorton, Andrew V White, Clare Heal
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Publicado: Public Library of Science (PLoS) 2021
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spelling oai:doaj.org-article:9fd7c23465e94d45b4b964dc9532b90e2021-12-02T20:09:52ZRheumatic heart disease in pregnancy and neonatal outcomes: A systematic review and meta-analysis.1932-620310.1371/journal.pone.0253581https://doaj.org/article/9fd7c23465e94d45b4b964dc9532b90e2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253581https://doaj.org/toc/1932-6203<h4>Purpose</h4>Associations between rheumatic heart disease (RHD) in pregnancy and fetal outcomes are relatively unknown. This study aimed to review rates and predictors of major adverse fetal outcomes of RHD in pregnancy.<h4>Methods</h4>Medline (Ovid), Pubmed, EMcare, Scopus, CINAHL, Informit, and WHOICTRP databases were searched for studies that reported rates of adverse perinatal events in women with RHD during pregnancy. Outcomes included preterm birth, intra-uterine growth restriction (IUGR), low-birth weight (LBW), perinatal death and percutaneous balloon mitral valvuloplasty intervention. Meta-analysis of fetal events by the New-York Heart Association (NYHA) heart failure classification, and the Mitral-valve Area (MVA) severity score was performed with unadjusted random effects models and heterogeneity of risk ratios (RR) was assessed with the I2 statistic. Quality of evidence was evaluated using the GRADE approach. The study was registered in PROSPERO (CRD42020161529).<h4>Findings</h4>The search identified 5949 non-duplicate records of which 136 full-text articles were assessed for eligibility and 22 studies included, 11 studies were eligible for meta-analyses. In 3928 pregnancies, high rates of preterm birth (9.35%-42.97%), LBW (12.98%-39.70%), IUGR (6.76%-22.40%) and perinatal death (0.00%-9.41%) were reported. NYHA III/IV pre-pregnancy was associated with higher rates of preterm birth (5 studies, RR 2.86, 95%CI 1.54-5.33), and perinatal death (6 studies, RR 3.23, 1.92-5.44). Moderate /severe mitral stenosis (MS) was associated with higher rates of preterm birth (3 studies, RR 2.05, 95%CI 1.02-4.11) and IUGR (3 studies, RR 2.46, 95%CI 1.02-5.95).<h4>Interpretation</h4>RHD during pregnancy is associated with adverse fetal outcomes. Maternal NYHA III/IV and moderate/severe MS in particular may predict poor prognosis.Joshua LiawBetrice WalkerLeanne HallSusan GortonAndrew V WhiteClare HealPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253581 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Joshua Liaw
Betrice Walker
Leanne Hall
Susan Gorton
Andrew V White
Clare Heal
Rheumatic heart disease in pregnancy and neonatal outcomes: A systematic review and meta-analysis.
description <h4>Purpose</h4>Associations between rheumatic heart disease (RHD) in pregnancy and fetal outcomes are relatively unknown. This study aimed to review rates and predictors of major adverse fetal outcomes of RHD in pregnancy.<h4>Methods</h4>Medline (Ovid), Pubmed, EMcare, Scopus, CINAHL, Informit, and WHOICTRP databases were searched for studies that reported rates of adverse perinatal events in women with RHD during pregnancy. Outcomes included preterm birth, intra-uterine growth restriction (IUGR), low-birth weight (LBW), perinatal death and percutaneous balloon mitral valvuloplasty intervention. Meta-analysis of fetal events by the New-York Heart Association (NYHA) heart failure classification, and the Mitral-valve Area (MVA) severity score was performed with unadjusted random effects models and heterogeneity of risk ratios (RR) was assessed with the I2 statistic. Quality of evidence was evaluated using the GRADE approach. The study was registered in PROSPERO (CRD42020161529).<h4>Findings</h4>The search identified 5949 non-duplicate records of which 136 full-text articles were assessed for eligibility and 22 studies included, 11 studies were eligible for meta-analyses. In 3928 pregnancies, high rates of preterm birth (9.35%-42.97%), LBW (12.98%-39.70%), IUGR (6.76%-22.40%) and perinatal death (0.00%-9.41%) were reported. NYHA III/IV pre-pregnancy was associated with higher rates of preterm birth (5 studies, RR 2.86, 95%CI 1.54-5.33), and perinatal death (6 studies, RR 3.23, 1.92-5.44). Moderate /severe mitral stenosis (MS) was associated with higher rates of preterm birth (3 studies, RR 2.05, 95%CI 1.02-4.11) and IUGR (3 studies, RR 2.46, 95%CI 1.02-5.95).<h4>Interpretation</h4>RHD during pregnancy is associated with adverse fetal outcomes. Maternal NYHA III/IV and moderate/severe MS in particular may predict poor prognosis.
format article
author Joshua Liaw
Betrice Walker
Leanne Hall
Susan Gorton
Andrew V White
Clare Heal
author_facet Joshua Liaw
Betrice Walker
Leanne Hall
Susan Gorton
Andrew V White
Clare Heal
author_sort Joshua Liaw
title Rheumatic heart disease in pregnancy and neonatal outcomes: A systematic review and meta-analysis.
title_short Rheumatic heart disease in pregnancy and neonatal outcomes: A systematic review and meta-analysis.
title_full Rheumatic heart disease in pregnancy and neonatal outcomes: A systematic review and meta-analysis.
title_fullStr Rheumatic heart disease in pregnancy and neonatal outcomes: A systematic review and meta-analysis.
title_full_unstemmed Rheumatic heart disease in pregnancy and neonatal outcomes: A systematic review and meta-analysis.
title_sort rheumatic heart disease in pregnancy and neonatal outcomes: a systematic review and meta-analysis.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/9fd7c23465e94d45b4b964dc9532b90e
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AT leannehall rheumaticheartdiseaseinpregnancyandneonataloutcomesasystematicreviewandmetaanalysis
AT susangorton rheumaticheartdiseaseinpregnancyandneonataloutcomesasystematicreviewandmetaanalysis
AT andrewvwhite rheumaticheartdiseaseinpregnancyandneonataloutcomesasystematicreviewandmetaanalysis
AT clareheal rheumaticheartdiseaseinpregnancyandneonataloutcomesasystematicreviewandmetaanalysis
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