Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens

Albomycins are promising drug candidates for the treatment of bacterial infections. Here, the authors describe the total syntheses of albomycins δ 1, δ 2, and ε, and evaluate their antimicrobial activity, identifying albomycin δ 2 as a strong agent against S. pneumoniae and S. aureus infections.

Guardado en:

Detalles Bibliográficos
Autores principales:	Zihua Lin, Xiaobo Xu, Sheng Zhao, Xiaohong Yang, Jian Guo, Qun Zhang, Chunmei Jing, Shawn Chen, Yun He
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9fd9b36c76ae4c8aa6389a0ec226f920
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9fd9b36c76ae4c8aa6389a0ec226f920
record_format	dspace
spelling	oai:doaj.org-article:9fd9b36c76ae4c8aa6389a0ec226f9202021-12-02T15:34:04ZTotal synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens10.1038/s41467-018-05821-12041-1723https://doaj.org/article/9fd9b36c76ae4c8aa6389a0ec226f9202018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05821-1https://doaj.org/toc/2041-1723Albomycins are promising drug candidates for the treatment of bacterial infections. Here, the authors describe the total syntheses of albomycins δ 1, δ 2, and ε, and evaluate their antimicrobial activity, identifying albomycin δ 2 as a strong agent against S. pneumoniae and S. aureus infections.Zihua LinXiaobo XuSheng ZhaoXiaohong YangJian GuoQun ZhangChunmei JingShawn ChenYun HeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zihua Lin Xiaobo Xu Sheng Zhao Xiaohong Yang Jian Guo Qun Zhang Chunmei Jing Shawn Chen Yun He Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens
description	Albomycins are promising drug candidates for the treatment of bacterial infections. Here, the authors describe the total syntheses of albomycins δ 1, δ 2, and ε, and evaluate their antimicrobial activity, identifying albomycin δ 2 as a strong agent against S. pneumoniae and S. aureus infections.
format	article
author	Zihua Lin Xiaobo Xu Sheng Zhao Xiaohong Yang Jian Guo Qun Zhang Chunmei Jing Shawn Chen Yun He
author_facet	Zihua Lin Xiaobo Xu Sheng Zhao Xiaohong Yang Jian Guo Qun Zhang Chunmei Jing Shawn Chen Yun He
author_sort	Zihua Lin
title	Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens
title_short	Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens
title_full	Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens
title_fullStr	Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens
title_full_unstemmed	Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens
title_sort	total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9fd9b36c76ae4c8aa6389a0ec226f920
work_keys_str_mv	AT zihualin totalsynthesisandantimicrobialevaluationofnaturalalbomycinsagainstclinicalpathogens AT xiaoboxu totalsynthesisandantimicrobialevaluationofnaturalalbomycinsagainstclinicalpathogens AT shengzhao totalsynthesisandantimicrobialevaluationofnaturalalbomycinsagainstclinicalpathogens AT xiaohongyang totalsynthesisandantimicrobialevaluationofnaturalalbomycinsagainstclinicalpathogens AT jianguo totalsynthesisandantimicrobialevaluationofnaturalalbomycinsagainstclinicalpathogens AT qunzhang totalsynthesisandantimicrobialevaluationofnaturalalbomycinsagainstclinicalpathogens AT chunmeijing totalsynthesisandantimicrobialevaluationofnaturalalbomycinsagainstclinicalpathogens AT shawnchen totalsynthesisandantimicrobialevaluationofnaturalalbomycinsagainstclinicalpathogens AT yunhe totalsynthesisandantimicrobialevaluationofnaturalalbomycinsagainstclinicalpathogens
_version_	1718386980801216512

Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens

Ejemplares similares