DEMOGRAPHIC VARANCE OF PRIMARY ESOPHAGEAL CANCER, BASED ON LOCATION AND HISTOPATHOLOGY IN PUNJAB-PAKISTAN

Objective: To determine the demographic variance in location and histopathological findings of esophageal carcinoma in Punjab-Pakistan. Study Design: Observational cross sectional study. Place and Duration of Study: This study was conducted in Multicentre Tertiary Care Hospitals of Combined Mi...

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Autores principales:	Muhammad Hafeez, Farhan Ahmed Majeed, Muhammad Tariq, Tariq Sarfraz Khan, Shahnawaz Ateeque, Abdul Latif Khattak
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	adenocarcinoma dysphagia esophageal malignancy Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9fd9df2e505b433d854f6f59f4853b44
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spelling	oai:doaj.org-article:9fd9df2e505b433d854f6f59f4853b442021-11-08T05:08:23ZDEMOGRAPHIC VARANCE OF PRIMARY ESOPHAGEAL CANCER, BASED ON LOCATION AND HISTOPATHOLOGY IN PUNJAB-PAKISTAN0030-96482411-8842https://doaj.org/article/9fd9df2e505b433d854f6f59f4853b442019-12-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3663/2484https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the demographic variance in location and histopathological findings of esophageal carcinoma in Punjab-Pakistan. Study Design: Observational cross sectional study. Place and Duration of Study: This study was conducted in Multicentre Tertiary Care Hospitals of Combined Military Hospital/Pak Emirates Military Hospital/Army Medical College Rawalpindi, Combined Military Hospital Kharian and Combined Military Hospital Multan from 2010 to 2017. Methodology: Patients with dysphagia and histopathology proven malignancy were included in this study. All patients had undergone flexible upper gastrointestinal endoscopy. Patients with lesions other than carcinoma, causing dysphagia and those with inconclusive histopathology were excluded from our study. The morpho-logical site of the carcinoma were divided into upper, middle, lower and at gastro-esophageal junction. Histo pathologically proven carcinoma of esophagus was reviewed for subtype of grading differentiation. Statistical analysis was done using IBM version SPSS 22. Results: Out of 150 patients, 85 (57%) were males and 65 (43%) were females. Their age ranged between 30 to 85 ± 12.33. Among one hundred and fifty patients 107 (71.33%) had Squamous Cell Carcinoma, 42 (28%), Adeno-carcinoma and metastasis in two cases. Frequency of distribution of esophageal carcinoma in North, East and South Districts of Punjab was 73%, 18% and 9% respectively. Esophageal Carcinoma in upper, middle, lower and Gastroesophageal junction was 22.5%, 35%, 15% and 27.5% respectively. Frequency of well differentiated SCC was 46 (30.6%) and well differentiated AC 31 (20.7%) respectively. Conclusion: SCC with male preponderance is more common in North of Punjab. Lower 1/3rd and GE junction esophageal tumor are the commonest sites in all North, East and South Punjab. Histopathological differentiation revealed Well Differentiated SCC along with significant rise in Adenocarcinomas compared to previous national studies.Muhammad HafeezFarhan Ahmed MajeedMuhammad TariqTariq Sarfraz KhanShahnawaz AteequeAbdul Latif KhattakArmy Medical College Rawalpindiarticleadenocarcinomadysphagiaesophageal malignancyMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 6, Pp 1346-1350 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	adenocarcinoma dysphagia esophageal malignancy Medicine R Medicine (General) R5-920
spellingShingle	adenocarcinoma dysphagia esophageal malignancy Medicine R Medicine (General) R5-920 Muhammad Hafeez Farhan Ahmed Majeed Muhammad Tariq Tariq Sarfraz Khan Shahnawaz Ateeque Abdul Latif Khattak DEMOGRAPHIC VARANCE OF PRIMARY ESOPHAGEAL CANCER, BASED ON LOCATION AND HISTOPATHOLOGY IN PUNJAB-PAKISTAN
description	Objective: To determine the demographic variance in location and histopathological findings of esophageal carcinoma in Punjab-Pakistan. Study Design: Observational cross sectional study. Place and Duration of Study: This study was conducted in Multicentre Tertiary Care Hospitals of Combined Military Hospital/Pak Emirates Military Hospital/Army Medical College Rawalpindi, Combined Military Hospital Kharian and Combined Military Hospital Multan from 2010 to 2017. Methodology: Patients with dysphagia and histopathology proven malignancy were included in this study. All patients had undergone flexible upper gastrointestinal endoscopy. Patients with lesions other than carcinoma, causing dysphagia and those with inconclusive histopathology were excluded from our study. The morpho-logical site of the carcinoma were divided into upper, middle, lower and at gastro-esophageal junction. Histo pathologically proven carcinoma of esophagus was reviewed for subtype of grading differentiation. Statistical analysis was done using IBM version SPSS 22. Results: Out of 150 patients, 85 (57%) were males and 65 (43%) were females. Their age ranged between 30 to 85 ± 12.33. Among one hundred and fifty patients 107 (71.33%) had Squamous Cell Carcinoma, 42 (28%), Adeno-carcinoma and metastasis in two cases. Frequency of distribution of esophageal carcinoma in North, East and South Districts of Punjab was 73%, 18% and 9% respectively. Esophageal Carcinoma in upper, middle, lower and Gastroesophageal junction was 22.5%, 35%, 15% and 27.5% respectively. Frequency of well differentiated SCC was 46 (30.6%) and well differentiated AC 31 (20.7%) respectively. Conclusion: SCC with male preponderance is more common in North of Punjab. Lower 1/3rd and GE junction esophageal tumor are the commonest sites in all North, East and South Punjab. Histopathological differentiation revealed Well Differentiated SCC along with significant rise in Adenocarcinomas compared to previous national studies.
format	article
author	Muhammad Hafeez Farhan Ahmed Majeed Muhammad Tariq Tariq Sarfraz Khan Shahnawaz Ateeque Abdul Latif Khattak
author_facet	Muhammad Hafeez Farhan Ahmed Majeed Muhammad Tariq Tariq Sarfraz Khan Shahnawaz Ateeque Abdul Latif Khattak
author_sort	Muhammad Hafeez
title	DEMOGRAPHIC VARANCE OF PRIMARY ESOPHAGEAL CANCER, BASED ON LOCATION AND HISTOPATHOLOGY IN PUNJAB-PAKISTAN
title_short	DEMOGRAPHIC VARANCE OF PRIMARY ESOPHAGEAL CANCER, BASED ON LOCATION AND HISTOPATHOLOGY IN PUNJAB-PAKISTAN
title_full	DEMOGRAPHIC VARANCE OF PRIMARY ESOPHAGEAL CANCER, BASED ON LOCATION AND HISTOPATHOLOGY IN PUNJAB-PAKISTAN
title_fullStr	DEMOGRAPHIC VARANCE OF PRIMARY ESOPHAGEAL CANCER, BASED ON LOCATION AND HISTOPATHOLOGY IN PUNJAB-PAKISTAN
title_full_unstemmed	DEMOGRAPHIC VARANCE OF PRIMARY ESOPHAGEAL CANCER, BASED ON LOCATION AND HISTOPATHOLOGY IN PUNJAB-PAKISTAN
title_sort	demographic varance of primary esophageal cancer, based on location and histopathology in punjab-pakistan
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/9fd9df2e505b433d854f6f59f4853b44
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DEMOGRAPHIC VARANCE OF PRIMARY ESOPHAGEAL CANCER, BASED ON LOCATION AND HISTOPATHOLOGY IN PUNJAB-PAKISTAN

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