HIVEP1 Is a Negative Regulator of NF-κB That Inhibits Systemic Inflammation in Sepsis

HIVEP1 Is a Negative Regulator of NF-κB That Inhibits Systemic Inflammation in Sepsis

Our previous work identified human immunodeficiency virus type I enhancer binding protein 1 (HIVEP1) as a putative driver of LPS-induced NF-κB signaling in humans in vivo. While HIVEP1 is known to interact with NF-ĸB binding DNA motifs, its function in mammalian cells is unknown. We report increased...

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Autores principales: Hisatake Matsumoto, Brendon P. Scicluna, Kin Ki Jim, Fahimeh Falahi, Wanhai Qin, Berke Gürkan, Erik Malmström, Mariska T. Meijer, Joe M. Butler, Hina N. Khan, Tsuyoshi Takagi, Shunsuke Ishii, Marcus J. Schultz, Diederik van de Beek, Alex F. de Vos, Cornelis van ‘t Veer, Tom van der Poll
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
HIVEP
MyD88
NF-κB
sepsis
toll-like receptors
Immunologic diseases. Allergy
RC581-607
Acceso en línea:https://doaj.org/article/9fdd81d996c34400a7bfadd47712bee9
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