SCAMP2/5 as diagnostic and prognostic markers for acute myeloid leukemia

Abstract The secretory carrier-associated membrane proteins (SCAMPs) are associated with the development of multiple human cancers. The role of SCAMPs in acute myeloid leukemia (AML), however, remains to be identified. In the present study, we explored expression patterns and prognostic value of SCA...

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Autores principales:	Can Yue, Siting Xie, Jiaying Zhong, Haijun Zhao, Zhijuan Lin, Li Zhang, Bing Xu, Yiming Luo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9fe21bfba6964320b124969821927862
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spelling	oai:doaj.org-article:9fe21bfba6964320b1249698219278622021-12-02T18:53:09ZSCAMP2/5 as diagnostic and prognostic markers for acute myeloid leukemia10.1038/s41598-021-96440-22045-2322https://doaj.org/article/9fe21bfba6964320b1249698219278622021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96440-2https://doaj.org/toc/2045-2322Abstract The secretory carrier-associated membrane proteins (SCAMPs) are associated with the development of multiple human cancers. The role of SCAMPs in acute myeloid leukemia (AML), however, remains to be identified. In the present study, we explored expression patterns and prognostic value of SCAMPs and network analysis of SCAMPs-related signaling pathways in AML using Oncomine, GEPIA, cBioPortal, LinkedOmics, DAVID and Metascape databases. Genetic alteration analysis revealed that the mutation rate of SCAMP genes was below 1% (9/1272) in AML, and there was no significant correlation between SCAMPs gene mutation and AML prognosis. However, the SCAMP2/5 mRNA levels were significantly higher in AML patients than in healthy controls. Moreover, high mRNA expressions of SCAMP2/4/5 were associated with poor overall survival, which might be due to that SCAMP2/4/5 and their co-expressed genes were associated with multiple pathways related to tumorigenesis and progression, including human T-cell leukemia virus 1 infection, acute myeloid leukemia, mTOR and NF-kappa B signaling pathways. These results suggest that SCAMP2/4/5 are potential prognostic markers for AML, and that SCAMP2 and SCAMP5 individually or in combination may be used as diagnostic markers for AML.Can YueSiting XieJiaying ZhongHaijun ZhaoZhijuan LinLi ZhangBing XuYiming LuoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Can Yue Siting Xie Jiaying Zhong Haijun Zhao Zhijuan Lin Li Zhang Bing Xu Yiming Luo SCAMP2/5 as diagnostic and prognostic markers for acute myeloid leukemia
description	Abstract The secretory carrier-associated membrane proteins (SCAMPs) are associated with the development of multiple human cancers. The role of SCAMPs in acute myeloid leukemia (AML), however, remains to be identified. In the present study, we explored expression patterns and prognostic value of SCAMPs and network analysis of SCAMPs-related signaling pathways in AML using Oncomine, GEPIA, cBioPortal, LinkedOmics, DAVID and Metascape databases. Genetic alteration analysis revealed that the mutation rate of SCAMP genes was below 1% (9/1272) in AML, and there was no significant correlation between SCAMPs gene mutation and AML prognosis. However, the SCAMP2/5 mRNA levels were significantly higher in AML patients than in healthy controls. Moreover, high mRNA expressions of SCAMP2/4/5 were associated with poor overall survival, which might be due to that SCAMP2/4/5 and their co-expressed genes were associated with multiple pathways related to tumorigenesis and progression, including human T-cell leukemia virus 1 infection, acute myeloid leukemia, mTOR and NF-kappa B signaling pathways. These results suggest that SCAMP2/4/5 are potential prognostic markers for AML, and that SCAMP2 and SCAMP5 individually or in combination may be used as diagnostic markers for AML.
format	article
author	Can Yue Siting Xie Jiaying Zhong Haijun Zhao Zhijuan Lin Li Zhang Bing Xu Yiming Luo
author_facet	Can Yue Siting Xie Jiaying Zhong Haijun Zhao Zhijuan Lin Li Zhang Bing Xu Yiming Luo
author_sort	Can Yue
title	SCAMP2/5 as diagnostic and prognostic markers for acute myeloid leukemia
title_short	SCAMP2/5 as diagnostic and prognostic markers for acute myeloid leukemia
title_full	SCAMP2/5 as diagnostic and prognostic markers for acute myeloid leukemia
title_fullStr	SCAMP2/5 as diagnostic and prognostic markers for acute myeloid leukemia
title_full_unstemmed	SCAMP2/5 as diagnostic and prognostic markers for acute myeloid leukemia
title_sort	scamp2/5 as diagnostic and prognostic markers for acute myeloid leukemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9fe21bfba6964320b124969821927862
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SCAMP2/5 as diagnostic and prognostic markers for acute myeloid leukemia

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