In Vitro and In Vivo Biocompatibility of Boron/Nitrogen Co-Doped Carbon Nano-Onions

Boron/nitrogen, co-doped, carbon nano-onions (BN-CNOs) have recently shown great promise as catalysts for the oxygen reduction reaction, due to the improved electronic properties imparted by the dopant atoms; however, the interactions of BN-CNOs with biological systems have not yet been explored. In...

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Autores principales:	Marta d’Amora, Adalberto Camisasca, Raul Arenal, Silvia Giordani
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	carbon nano-onion heteroatom doping cells zebrafish biosafety Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/9fe31b1f781c44388689f45fbd6a9578
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spelling	oai:doaj.org-article:9fe31b1f781c44388689f45fbd6a95782021-11-25T18:31:45ZIn Vitro and In Vivo Biocompatibility of Boron/Nitrogen Co-Doped Carbon Nano-Onions10.3390/nano111130172079-4991https://doaj.org/article/9fe31b1f781c44388689f45fbd6a95782021-11-01T00:00:00Zhttps://www.mdpi.com/2079-4991/11/11/3017https://doaj.org/toc/2079-4991Boron/nitrogen, co-doped, carbon nano-onions (BN-CNOs) have recently shown great promise as catalysts for the oxygen reduction reaction, due to the improved electronic properties imparted by the dopant atoms; however, the interactions of BN-CNOs with biological systems have not yet been explored. In this study, we examined the toxicological profiles of BN-CNOs and oxidized BN-CNOs (oxi-BN-CNOs) in vitro in both healthy and cancer cell lines, as well as on the embryonic stages of zebrafish (<i>Danio rerio</i>) in vivo. The cell viabilities of both cell lines cells were not affected after treatment with different concentrations of both doped CNO derivatives. On the other hand, the analysis of BN-CNOs and oxidized BN-CNO interactions with zebrafish embryos did not report any kind of perturbations, in agreement with the in vitro results. Our results show that both doped CNO derivatives possess a high biocompatibility and biosafety in cells and more complex systems.Marta d’AmoraAdalberto CamisascaRaul ArenalSilvia GiordaniMDPI AGarticlecarbon nano-onionheteroatom dopingcellszebrafishbiosafetyChemistryQD1-999ENNanomaterials, Vol 11, Iss 3017, p 3017 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	carbon nano-onion heteroatom doping cells zebrafish biosafety Chemistry QD1-999
spellingShingle	carbon nano-onion heteroatom doping cells zebrafish biosafety Chemistry QD1-999 Marta d’Amora Adalberto Camisasca Raul Arenal Silvia Giordani In Vitro and In Vivo Biocompatibility of Boron/Nitrogen Co-Doped Carbon Nano-Onions
description	Boron/nitrogen, co-doped, carbon nano-onions (BN-CNOs) have recently shown great promise as catalysts for the oxygen reduction reaction, due to the improved electronic properties imparted by the dopant atoms; however, the interactions of BN-CNOs with biological systems have not yet been explored. In this study, we examined the toxicological profiles of BN-CNOs and oxidized BN-CNOs (oxi-BN-CNOs) in vitro in both healthy and cancer cell lines, as well as on the embryonic stages of zebrafish (<i>Danio rerio</i>) in vivo. The cell viabilities of both cell lines cells were not affected after treatment with different concentrations of both doped CNO derivatives. On the other hand, the analysis of BN-CNOs and oxidized BN-CNO interactions with zebrafish embryos did not report any kind of perturbations, in agreement with the in vitro results. Our results show that both doped CNO derivatives possess a high biocompatibility and biosafety in cells and more complex systems.
format	article
author	Marta d’Amora Adalberto Camisasca Raul Arenal Silvia Giordani
author_facet	Marta d’Amora Adalberto Camisasca Raul Arenal Silvia Giordani
author_sort	Marta d’Amora
title	In Vitro and In Vivo Biocompatibility of Boron/Nitrogen Co-Doped Carbon Nano-Onions
title_short	In Vitro and In Vivo Biocompatibility of Boron/Nitrogen Co-Doped Carbon Nano-Onions
title_full	In Vitro and In Vivo Biocompatibility of Boron/Nitrogen Co-Doped Carbon Nano-Onions
title_fullStr	In Vitro and In Vivo Biocompatibility of Boron/Nitrogen Co-Doped Carbon Nano-Onions
title_full_unstemmed	In Vitro and In Vivo Biocompatibility of Boron/Nitrogen Co-Doped Carbon Nano-Onions
title_sort	in vitro and in vivo biocompatibility of boron/nitrogen co-doped carbon nano-onions
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9fe31b1f781c44388689f45fbd6a9578
work_keys_str_mv	AT martadamora invitroandinvivobiocompatibilityofboronnitrogencodopedcarbonnanoonions AT adalbertocamisasca invitroandinvivobiocompatibilityofboronnitrogencodopedcarbonnanoonions AT raularenal invitroandinvivobiocompatibilityofboronnitrogencodopedcarbonnanoonions AT silviagiordani invitroandinvivobiocompatibilityofboronnitrogencodopedcarbonnanoonions
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In Vitro and In Vivo Biocompatibility of Boron/Nitrogen Co-Doped Carbon Nano-Onions

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