A review of ramelteon in the treatment of sleep disorders

David N NeubauerDepartment of Psychiatry, Johns Hopkins University School of MedicineAbstract: Ramelteon is a selective melatonin receptor (MT1 and MT2) agonist that has been approved by the US Food and Drug Administration for the treatment of insomnia characterized by difficulty with sleep onset. I...

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Autor principal:	David N Neubauer
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/9fe37eaa595747798f535232e235e187
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spelling	oai:doaj.org-article:9fe37eaa595747798f535232e235e1872021-12-02T01:37:02ZA review of ramelteon in the treatment of sleep disorders1176-63281178-2021https://doaj.org/article/9fe37eaa595747798f535232e235e1872008-03-01T00:00:00Zhttp://www.dovepress.com/a-review-of-ramelteon-in-the-treatment-of-sleep-disorders-a997https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021David N NeubauerDepartment of Psychiatry, Johns Hopkins University School of MedicineAbstract: Ramelteon is a selective melatonin receptor (MT1 and MT2) agonist that has been approved by the US Food and Drug Administration for the treatment of insomnia characterized by difficulty with sleep onset. It is the only approved sleep-promoting medication that does not have a direct sedating effect, but rather enhances sleep through effects on sleep regulatory mechanisms within the suprachiasmatic nucleus. Ramelteon has been shown to have no abuse liability and therefore is not scheduled by the U.S. Drug Enforcement Agency as a controlled substance. It is available as an 8 mg tablet, which should be taken approximately 30 minutes prior to bedtime. The FDA approval contains no limitation on how long the medication may be prescribed.Keywords: circadian rhythm, insomnia, melatonin receptors, ramelteon, sleep-wake cycle David N NeubauerDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 1, Pp 69-79 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 David N Neubauer A review of ramelteon in the treatment of sleep disorders
description	David N NeubauerDepartment of Psychiatry, Johns Hopkins University School of MedicineAbstract: Ramelteon is a selective melatonin receptor (MT1 and MT2) agonist that has been approved by the US Food and Drug Administration for the treatment of insomnia characterized by difficulty with sleep onset. It is the only approved sleep-promoting medication that does not have a direct sedating effect, but rather enhances sleep through effects on sleep regulatory mechanisms within the suprachiasmatic nucleus. Ramelteon has been shown to have no abuse liability and therefore is not scheduled by the U.S. Drug Enforcement Agency as a controlled substance. It is available as an 8 mg tablet, which should be taken approximately 30 minutes prior to bedtime. The FDA approval contains no limitation on how long the medication may be prescribed.Keywords: circadian rhythm, insomnia, melatonin receptors, ramelteon, sleep-wake cycle
format	article
author	David N Neubauer
author_facet	David N Neubauer
author_sort	David N Neubauer
title	A review of ramelteon in the treatment of sleep disorders
title_short	A review of ramelteon in the treatment of sleep disorders
title_full	A review of ramelteon in the treatment of sleep disorders
title_fullStr	A review of ramelteon in the treatment of sleep disorders
title_full_unstemmed	A review of ramelteon in the treatment of sleep disorders
title_sort	review of ramelteon in the treatment of sleep disorders
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/9fe37eaa595747798f535232e235e187
work_keys_str_mv	AT davidnneubauer areviewoframelteoninthetreatmentofsleepdisorders AT davidnneubauer reviewoframelteoninthetreatmentofsleepdisorders
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A review of ramelteon in the treatment of sleep disorders

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