Study on pivot-point vibration of molecular bond-rupture events by quartz crystal microbalance for biomedical diagnostics

Yong J Yuan, Renjie JiaLaboratory of Biosensing and MicroMechatronics, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, People&#39;s Republic of ChinaAbstract: Bond-rupture scanning for biomedical diagnostics is examined using quartz crystal micro...

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Autores principales:	Yuan YJ, Jia R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9fe752994c9649aba246503d2fd0eddc
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spelling	oai:doaj.org-article:9fe752994c9649aba246503d2fd0eddc2021-12-02T02:31:47ZStudy on pivot-point vibration of molecular bond-rupture events by quartz crystal microbalance for biomedical diagnostics1176-91141178-2013https://doaj.org/article/9fe752994c9649aba246503d2fd0eddc2012-01-01T00:00:00Zhttp://www.dovepress.com/study-on-pivot-point-vibration-of-molecular-bond-rupture-events-by-qua-a9126https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Yong J Yuan, Renjie JiaLaboratory of Biosensing and MicroMechatronics, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, People&#39;s Republic of ChinaAbstract: Bond-rupture scanning for biomedical diagnostics is examined using quartz crystal microbalance (QCM) experiments and microparticle mechanics modeling calculations. Specific and nonspecific interactions between a microparticle and its binding QCM surface can be distinguished by gradually increasing the amplitude of driving voltage applied to QCM and monitoring its frequency changes. This research proposes a mechanical model of interactions between biological molecules and a QCM substrate surface. The mechanical force required to break a biotin&ndash;streptavidin bond was calculated through a one-pivot-point bottom-up vibration model. The bond-rupture force increases with an increase of the microparticle radius, the QCM resonant frequency, and the amplitude of driving voltage applied to the QCM. The significance of the research on biological molecular bond rupture is extremely important in characterizing microbial (such as cells and virus) specificity, due to the force magnitude needed to break bonds using a transducer.Keywords: bond rupture, mechanical force, biomolecular binding energy spectra, quartz crystal microbalance (QCM)Yuan YJJia RDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 381-391 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Yuan YJ Jia R Study on pivot-point vibration of molecular bond-rupture events by quartz crystal microbalance for biomedical diagnostics
description	Yong J Yuan, Renjie JiaLaboratory of Biosensing and MicroMechatronics, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, People&#39;s Republic of ChinaAbstract: Bond-rupture scanning for biomedical diagnostics is examined using quartz crystal microbalance (QCM) experiments and microparticle mechanics modeling calculations. Specific and nonspecific interactions between a microparticle and its binding QCM surface can be distinguished by gradually increasing the amplitude of driving voltage applied to QCM and monitoring its frequency changes. This research proposes a mechanical model of interactions between biological molecules and a QCM substrate surface. The mechanical force required to break a biotin&ndash;streptavidin bond was calculated through a one-pivot-point bottom-up vibration model. The bond-rupture force increases with an increase of the microparticle radius, the QCM resonant frequency, and the amplitude of driving voltage applied to the QCM. The significance of the research on biological molecular bond rupture is extremely important in characterizing microbial (such as cells and virus) specificity, due to the force magnitude needed to break bonds using a transducer.Keywords: bond rupture, mechanical force, biomolecular binding energy spectra, quartz crystal microbalance (QCM)
format	article
author	Yuan YJ Jia R
author_facet	Yuan YJ Jia R
author_sort	Yuan YJ
title	Study on pivot-point vibration of molecular bond-rupture events by quartz crystal microbalance for biomedical diagnostics
title_short	Study on pivot-point vibration of molecular bond-rupture events by quartz crystal microbalance for biomedical diagnostics
title_full	Study on pivot-point vibration of molecular bond-rupture events by quartz crystal microbalance for biomedical diagnostics
title_fullStr	Study on pivot-point vibration of molecular bond-rupture events by quartz crystal microbalance for biomedical diagnostics
title_full_unstemmed	Study on pivot-point vibration of molecular bond-rupture events by quartz crystal microbalance for biomedical diagnostics
title_sort	study on pivot-point vibration of molecular bond-rupture events by quartz crystal microbalance for biomedical diagnostics
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/9fe752994c9649aba246503d2fd0eddc
work_keys_str_mv	AT yuanyj studyonpivotpointvibrationofmolecularbondruptureeventsbyquartzcrystalmicrobalanceforbiomedicaldiagnostics AT jiar studyonpivotpointvibrationofmolecularbondruptureeventsbyquartzcrystalmicrobalanceforbiomedicaldiagnostics
_version_	1718402427307163648

Study on pivot-point vibration of molecular bond-rupture events by quartz crystal microbalance for biomedical diagnostics

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