Twenty-four-hour ambulatory blood-pressure variability is associated with total magnetic resonance-imaging burden in cerebral small-vessel disease

Shuna Yang,* Junliang Yuan,* Wei Qin, Lei Yang, Huimin Fan, Yue Li, Wenli Hu Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China *These authors contributed equally to this work Background: Lacunae, brain atrophy, white matter hyperintensity, enlarged per...

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Autores principales:	Yang S, Yuan J, Qin W, Yang L, Fan H, Li Y, Hu W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	cerebral small vessel diseases blood pressure variability ambulatory blood pressure monitoring magnetic resonance imaging burden Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/9fe9ae63c92f4362adee26b6c9b44303
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spelling	oai:doaj.org-article:9fe9ae63c92f4362adee26b6c9b443032021-12-02T01:41:37ZTwenty-four-hour ambulatory blood-pressure variability is associated with total magnetic resonance-imaging burden in cerebral small-vessel disease1178-1998https://doaj.org/article/9fe9ae63c92f4362adee26b6c9b443032018-08-01T00:00:00Zhttps://www.dovepress.com/twenty-four-hour-ambulatory-blood-pressure-variability-is-associated-w-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Shuna Yang,* Junliang Yuan,* Wei Qin, Lei Yang, Huimin Fan, Yue Li, Wenli Hu Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China *These authors contributed equally to this work Background: Lacunae, brain atrophy, white matter hyperintensity, enlarged perivascular space and microbleed are magnetic resonance imaging (MRI) markers of cerebral small-vessel disease (cSVD). Studies have reported that higher blood pressure variability (BPV) predicted cardiovascular risk in hypertensive patients; however, the association between BPV and the total MRI burden of cSVD has not been investigated. In this study, we aimed to explore this relationship between BPV and cSVD MRI burden. Methods: We prospectively recruited patients who attended our hospital for annual physical examination. Twenty-four-hour ambulatory BP monitoring was performed using an automated system. BPV was quantified by SD, weighted SD, and coefficient of variation. One point was awarded for the presence of each marker, producing a score between 0 and 5. Spearman correlation and ordinal logistic regression analyses were used to test the relationship between BPV and total cSVD MRI burden. Results: A total of 251 subjects with an average age of 68 years were enrolled in this study, and 52.6% were male; 163 (64.94%) had one or more markers of cSVD. Correlation analysis indicated that higher systolic BP (SBP) levels and BPV metrics of SBP were positively related to higher cSVD burden. Ordinal logistic regression analyses demonstrated that higher SBP levels and SBP variability were independent risk factors for cSVD. There were no significant differences in 24-hour, day and night diastolic BP levels or BPV metrics of diastolic BP among the five subgroups. Conclusion: Twenty-four-hour, day and night SBP levels and SBP variability were positively related to cSVD burden. Higher SBP levels and SBP variability were independent risk factors for cSVD. Keywords: cerebral small-vessel diseases, blood pressure variability, ambulatory blood pressure monitoring, magnetic resonance-imaging burdenYang SYuan JQin WYang LFan HLi YHu WDove Medical Pressarticlecerebral small vessel diseasesblood pressure variabilityambulatory blood pressure monitoringmagnetic resonance imaging burdenGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 1419-1427 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	cerebral small vessel diseases blood pressure variability ambulatory blood pressure monitoring magnetic resonance imaging burden Geriatrics RC952-954.6
spellingShingle	cerebral small vessel diseases blood pressure variability ambulatory blood pressure monitoring magnetic resonance imaging burden Geriatrics RC952-954.6 Yang S Yuan J Qin W Yang L Fan H Li Y Hu W Twenty-four-hour ambulatory blood-pressure variability is associated with total magnetic resonance-imaging burden in cerebral small-vessel disease
description	Shuna Yang,* Junliang Yuan,* Wei Qin, Lei Yang, Huimin Fan, Yue Li, Wenli Hu Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China *These authors contributed equally to this work Background: Lacunae, brain atrophy, white matter hyperintensity, enlarged perivascular space and microbleed are magnetic resonance imaging (MRI) markers of cerebral small-vessel disease (cSVD). Studies have reported that higher blood pressure variability (BPV) predicted cardiovascular risk in hypertensive patients; however, the association between BPV and the total MRI burden of cSVD has not been investigated. In this study, we aimed to explore this relationship between BPV and cSVD MRI burden. Methods: We prospectively recruited patients who attended our hospital for annual physical examination. Twenty-four-hour ambulatory BP monitoring was performed using an automated system. BPV was quantified by SD, weighted SD, and coefficient of variation. One point was awarded for the presence of each marker, producing a score between 0 and 5. Spearman correlation and ordinal logistic regression analyses were used to test the relationship between BPV and total cSVD MRI burden. Results: A total of 251 subjects with an average age of 68 years were enrolled in this study, and 52.6% were male; 163 (64.94%) had one or more markers of cSVD. Correlation analysis indicated that higher systolic BP (SBP) levels and BPV metrics of SBP were positively related to higher cSVD burden. Ordinal logistic regression analyses demonstrated that higher SBP levels and SBP variability were independent risk factors for cSVD. There were no significant differences in 24-hour, day and night diastolic BP levels or BPV metrics of diastolic BP among the five subgroups. Conclusion: Twenty-four-hour, day and night SBP levels and SBP variability were positively related to cSVD burden. Higher SBP levels and SBP variability were independent risk factors for cSVD. Keywords: cerebral small-vessel diseases, blood pressure variability, ambulatory blood pressure monitoring, magnetic resonance-imaging burden
format	article
author	Yang S Yuan J Qin W Yang L Fan H Li Y Hu W
author_facet	Yang S Yuan J Qin W Yang L Fan H Li Y Hu W
author_sort	Yang S
title	Twenty-four-hour ambulatory blood-pressure variability is associated with total magnetic resonance-imaging burden in cerebral small-vessel disease
title_short	Twenty-four-hour ambulatory blood-pressure variability is associated with total magnetic resonance-imaging burden in cerebral small-vessel disease
title_full	Twenty-four-hour ambulatory blood-pressure variability is associated with total magnetic resonance-imaging burden in cerebral small-vessel disease
title_fullStr	Twenty-four-hour ambulatory blood-pressure variability is associated with total magnetic resonance-imaging burden in cerebral small-vessel disease
title_full_unstemmed	Twenty-four-hour ambulatory blood-pressure variability is associated with total magnetic resonance-imaging burden in cerebral small-vessel disease
title_sort	twenty-four-hour ambulatory blood-pressure variability is associated with total magnetic resonance-imaging burden in cerebral small-vessel disease
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/9fe9ae63c92f4362adee26b6c9b44303
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_version_	1718402911155781632

Twenty-four-hour ambulatory blood-pressure variability is associated with total magnetic resonance-imaging burden in cerebral small-vessel disease

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