Metabolic signatures of extreme longevity in northern Italian centenarians reveal a complex remodeling of lipids, amino acids, and gut microbiota metabolism.
The aging phenotype in humans has been thoroughly studied but a detailed metabolic profiling capable of shading light on the underpinning biological processes of longevity is still missing. Here using a combined metabonomics approach compromising holistic (1)H-NMR profiling and targeted MS approache...
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Autores principales: | Sebastiano Collino, Ivan Montoliu, François-Pierre J Martin, Max Scherer, Daniela Mari, Stefano Salvioli, Laura Bucci, Rita Ostan, Daniela Monti, Elena Biagi, Patrizia Brigidi, Claudio Franceschi, Serge Rezzi |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2013
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Materias: | |
Acceso en línea: | https://doaj.org/article/9fea8025779a466e820ab41554a56f61 |
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