The fate of methylmercury through the formation of bismethylmercury sulfide as an intermediate in mice

Abstract A previous study by our group indicated that methylmercury (MeHg) is biotransformed to bismethylmercury sulfide [(MeHg)2S)] by interaction with reactive sulfur species (RSS) produced in the body. In the present study, we explored the transformation of MeHg to (MeHg)2S in the gut and the sub...

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Autores principales:	Yumi Abiko, Yusuke Katayama, Wenyang Zhao, Sawako Horai, Kenji Sakurai, Yoshito Kumagai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9ff19bce70354b1192b4c04562513d22
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spelling	oai:doaj.org-article:9ff19bce70354b1192b4c04562513d222021-12-02T17:51:16ZThe fate of methylmercury through the formation of bismethylmercury sulfide as an intermediate in mice10.1038/s41598-021-96579-y2045-2322https://doaj.org/article/9ff19bce70354b1192b4c04562513d222021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96579-yhttps://doaj.org/toc/2045-2322Abstract A previous study by our group indicated that methylmercury (MeHg) is biotransformed to bismethylmercury sulfide [(MeHg)2S)] by interaction with reactive sulfur species (RSS) produced in the body. In the present study, we explored the transformation of MeHg to (MeHg)2S in the gut and the subsequent fate of (MeHg)2S in vitro and in vivo. An ex vivo experiment suggested the possibility of the extracellular transformation of MeHg to (MeHg)2S in the distal colon, and accordingly, the MeHg sulfur adduct was detected in the intestinal contents and feces of mice administered MeHg, suggesting that (MeHg)2S is formed through reactions between MeHg and RSS in the gut. In a cell-free system, we found that (MeHg)2S undergoes degradation in a time-dependent manner, resulting in the formation of mercury sulfide and dimethylmercury (DMeHg), as determined by X-ray diffraction and gas chromatography/mass spectrometry, respectively. We also identified DMeHg in the expiration after the intraperitoneal administration of (MeHg)2S to mice. Thus, our present study identified a new fate of MeHg through (MeHg)2S as an intermediate, which leads to conversion of volatile DMeHg in the body.Yumi AbikoYusuke KatayamaWenyang ZhaoSawako HoraiKenji SakuraiYoshito KumagaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yumi Abiko Yusuke Katayama Wenyang Zhao Sawako Horai Kenji Sakurai Yoshito Kumagai The fate of methylmercury through the formation of bismethylmercury sulfide as an intermediate in mice
description	Abstract A previous study by our group indicated that methylmercury (MeHg) is biotransformed to bismethylmercury sulfide [(MeHg)2S)] by interaction with reactive sulfur species (RSS) produced in the body. In the present study, we explored the transformation of MeHg to (MeHg)2S in the gut and the subsequent fate of (MeHg)2S in vitro and in vivo. An ex vivo experiment suggested the possibility of the extracellular transformation of MeHg to (MeHg)2S in the distal colon, and accordingly, the MeHg sulfur adduct was detected in the intestinal contents and feces of mice administered MeHg, suggesting that (MeHg)2S is formed through reactions between MeHg and RSS in the gut. In a cell-free system, we found that (MeHg)2S undergoes degradation in a time-dependent manner, resulting in the formation of mercury sulfide and dimethylmercury (DMeHg), as determined by X-ray diffraction and gas chromatography/mass spectrometry, respectively. We also identified DMeHg in the expiration after the intraperitoneal administration of (MeHg)2S to mice. Thus, our present study identified a new fate of MeHg through (MeHg)2S as an intermediate, which leads to conversion of volatile DMeHg in the body.
format	article
author	Yumi Abiko Yusuke Katayama Wenyang Zhao Sawako Horai Kenji Sakurai Yoshito Kumagai
author_facet	Yumi Abiko Yusuke Katayama Wenyang Zhao Sawako Horai Kenji Sakurai Yoshito Kumagai
author_sort	Yumi Abiko
title	The fate of methylmercury through the formation of bismethylmercury sulfide as an intermediate in mice
title_short	The fate of methylmercury through the formation of bismethylmercury sulfide as an intermediate in mice
title_full	The fate of methylmercury through the formation of bismethylmercury sulfide as an intermediate in mice
title_fullStr	The fate of methylmercury through the formation of bismethylmercury sulfide as an intermediate in mice
title_full_unstemmed	The fate of methylmercury through the formation of bismethylmercury sulfide as an intermediate in mice
title_sort	fate of methylmercury through the formation of bismethylmercury sulfide as an intermediate in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9ff19bce70354b1192b4c04562513d22
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The fate of methylmercury through the formation of bismethylmercury sulfide as an intermediate in mice

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