Continuous glucose monitoring during pregnancy in healthy mice

Abstract During pregnancy, metabolic adaptations occur to maintain the balance between maternal and foetal growth, including increased insulin secretion and decreased insulin sensitivity. When the body fails to adjust, gestational diabetes mellitus develops. To gain insight in the pregnancy-induced...

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Autores principales:	Caroline Wuyts, Caroline Simoens, Silvia Pinto, Koenraad Philippaert, Rudi Vennekens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9ff1a63225d3457eb41d247a1e158da1
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spelling	oai:doaj.org-article:9ff1a63225d3457eb41d247a1e158da12021-12-02T13:34:57ZContinuous glucose monitoring during pregnancy in healthy mice10.1038/s41598-021-83901-x2045-2322https://doaj.org/article/9ff1a63225d3457eb41d247a1e158da12021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83901-xhttps://doaj.org/toc/2045-2322Abstract During pregnancy, metabolic adaptations occur to maintain the balance between maternal and foetal growth, including increased insulin secretion and decreased insulin sensitivity. When the body fails to adjust, gestational diabetes mellitus develops. To gain insight in the pregnancy-induced adaptations, we applied continuous glucose monitoring via telemetric transmitters. We show that continuous glucose monitoring in conscious, non-stressed, freely moving mice throughout the full pregnancy is feasible, accurate and safe. We show that healthy mice during a full pregnancy develop adaptations in glucose homeostasis reminiscent of those in pregnant women. Furthermore, continuous glucose monitoring allows the complete analysis of all aspects of glucose excursions associated with spontaneous feeding episodes, and the thorough analysis of glycaemic variability. In conclusion, continuous glucose monitoring allows a detailed description of the glycaemic status during pregnancy, which will help to unravel specific mechanisms for gestational diabetes mellitus.Caroline WuytsCaroline SimoensSilvia PintoKoenraad PhilippaertRudi VennekensNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Caroline Wuyts Caroline Simoens Silvia Pinto Koenraad Philippaert Rudi Vennekens Continuous glucose monitoring during pregnancy in healthy mice
description	Abstract During pregnancy, metabolic adaptations occur to maintain the balance between maternal and foetal growth, including increased insulin secretion and decreased insulin sensitivity. When the body fails to adjust, gestational diabetes mellitus develops. To gain insight in the pregnancy-induced adaptations, we applied continuous glucose monitoring via telemetric transmitters. We show that continuous glucose monitoring in conscious, non-stressed, freely moving mice throughout the full pregnancy is feasible, accurate and safe. We show that healthy mice during a full pregnancy develop adaptations in glucose homeostasis reminiscent of those in pregnant women. Furthermore, continuous glucose monitoring allows the complete analysis of all aspects of glucose excursions associated with spontaneous feeding episodes, and the thorough analysis of glycaemic variability. In conclusion, continuous glucose monitoring allows a detailed description of the glycaemic status during pregnancy, which will help to unravel specific mechanisms for gestational diabetes mellitus.
format	article
author	Caroline Wuyts Caroline Simoens Silvia Pinto Koenraad Philippaert Rudi Vennekens
author_facet	Caroline Wuyts Caroline Simoens Silvia Pinto Koenraad Philippaert Rudi Vennekens
author_sort	Caroline Wuyts
title	Continuous glucose monitoring during pregnancy in healthy mice
title_short	Continuous glucose monitoring during pregnancy in healthy mice
title_full	Continuous glucose monitoring during pregnancy in healthy mice
title_fullStr	Continuous glucose monitoring during pregnancy in healthy mice
title_full_unstemmed	Continuous glucose monitoring during pregnancy in healthy mice
title_sort	continuous glucose monitoring during pregnancy in healthy mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9ff1a63225d3457eb41d247a1e158da1
work_keys_str_mv	AT carolinewuyts continuousglucosemonitoringduringpregnancyinhealthymice AT carolinesimoens continuousglucosemonitoringduringpregnancyinhealthymice AT silviapinto continuousglucosemonitoringduringpregnancyinhealthymice AT koenraadphilippaert continuousglucosemonitoringduringpregnancyinhealthymice AT rudivennekens continuousglucosemonitoringduringpregnancyinhealthymice
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Continuous glucose monitoring during pregnancy in healthy mice

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