DYNAMICS OF CYTOKINE LEVELS IN THE HOSPITALIZED PATIENTS WITH DIFFERENT CLINICAL TYPES OF ACUTE CORONARY SYNDROME

The study included 120 patients with acute coronary syndrome (ACS), which were divided: in two groups, respectively, with ACS-ST segment elevation (group 1, n = 80), and without this clinical sign (group 2, n = 40). The levels of interleukins (IL)-6, -8, -10, and tumor necrosis factor-α (TNFα) were...

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Autores principales:	S. A. Berns, E. S. Kiprina, E. A. Shmidt, A. V. Veremeev, O. L. Barbarash
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	cytokine dynamics acute coronary syndrome st elevation trait Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/9ff210b355834ee0a967fbcd61616b9b
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spelling	oai:doaj.org-article:9ff210b355834ee0a967fbcd61616b9b2021-11-18T08:03:45ZDYNAMICS OF CYTOKINE LEVELS IN THE HOSPITALIZED PATIENTS WITH DIFFERENT CLINICAL TYPES OF ACUTE CORONARY SYNDROME1563-06252313-741X10.15789/1563-0625-2016-1-33-40https://doaj.org/article/9ff210b355834ee0a967fbcd61616b9b2016-04-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/986https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe study included 120 patients with acute coronary syndrome (ACS), which were divided: in two groups, respectively, with ACS-ST segment elevation (group 1, n = 80), and without this clinical sign (group 2, n = 40). The levels of interleukins (IL)-6, -8, -10, and tumor necrosis factor-α (TNFα) were determined by quantitative ELISA test on the 1st and 10th days of the study. In both groups, the IL-8 and TNFα values on day 1 were similar to the reference level, whereas IL-10 levels were significantly reduced as compared to the standard values. IL-6 level was increased in patients with ACS-ST elevation only in acute phase of ACS, while the patients from group 2 showed normal IL-6 values. On the day 10, TNFα levels in the both groups of patients were significantly increased as compared to the 1st day, whereas IL-6 and IL-10 levels were significantly decreased by the day 10 in both groups of patients. Differential dynamics of IL-8 was observed for these groups of the patients from the day 1 to day 10, i.e., the IL-8 concentration showed a tendency to increase (by 40%) for the group 1 and decrease by 54% in the group 2. In conclusion, the patient grouped by different clinical ACS variants exhibit a similar dynamics of cytokine concentrations, but an increase of IL-8 by the day 10 of the disease was seen only in patients with ACS segment elevation. It may be indicative of different intensity of the inflammatory response.S. A. BernsE. S. KiprinaE. A. ShmidtA. V. VeremeevO. L. BarbarashSPb RAACIarticlecytokine dynamicsacute coronary syndromest elevation traitImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 18, Iss 1, Pp 33-40 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytokine dynamics acute coronary syndrome st elevation trait Immunologic diseases. Allergy RC581-607
spellingShingle	cytokine dynamics acute coronary syndrome st elevation trait Immunologic diseases. Allergy RC581-607 S. A. Berns E. S. Kiprina E. A. Shmidt A. V. Veremeev O. L. Barbarash DYNAMICS OF CYTOKINE LEVELS IN THE HOSPITALIZED PATIENTS WITH DIFFERENT CLINICAL TYPES OF ACUTE CORONARY SYNDROME
description	The study included 120 patients with acute coronary syndrome (ACS), which were divided: in two groups, respectively, with ACS-ST segment elevation (group 1, n = 80), and without this clinical sign (group 2, n = 40). The levels of interleukins (IL)-6, -8, -10, and tumor necrosis factor-α (TNFα) were determined by quantitative ELISA test on the 1st and 10th days of the study. In both groups, the IL-8 and TNFα values on day 1 were similar to the reference level, whereas IL-10 levels were significantly reduced as compared to the standard values. IL-6 level was increased in patients with ACS-ST elevation only in acute phase of ACS, while the patients from group 2 showed normal IL-6 values. On the day 10, TNFα levels in the both groups of patients were significantly increased as compared to the 1st day, whereas IL-6 and IL-10 levels were significantly decreased by the day 10 in both groups of patients. Differential dynamics of IL-8 was observed for these groups of the patients from the day 1 to day 10, i.e., the IL-8 concentration showed a tendency to increase (by 40%) for the group 1 and decrease by 54% in the group 2. In conclusion, the patient grouped by different clinical ACS variants exhibit a similar dynamics of cytokine concentrations, but an increase of IL-8 by the day 10 of the disease was seen only in patients with ACS segment elevation. It may be indicative of different intensity of the inflammatory response.
format	article
author	S. A. Berns E. S. Kiprina E. A. Shmidt A. V. Veremeev O. L. Barbarash
author_facet	S. A. Berns E. S. Kiprina E. A. Shmidt A. V. Veremeev O. L. Barbarash
author_sort	S. A. Berns
title	DYNAMICS OF CYTOKINE LEVELS IN THE HOSPITALIZED PATIENTS WITH DIFFERENT CLINICAL TYPES OF ACUTE CORONARY SYNDROME
title_short	DYNAMICS OF CYTOKINE LEVELS IN THE HOSPITALIZED PATIENTS WITH DIFFERENT CLINICAL TYPES OF ACUTE CORONARY SYNDROME
title_full	DYNAMICS OF CYTOKINE LEVELS IN THE HOSPITALIZED PATIENTS WITH DIFFERENT CLINICAL TYPES OF ACUTE CORONARY SYNDROME
title_fullStr	DYNAMICS OF CYTOKINE LEVELS IN THE HOSPITALIZED PATIENTS WITH DIFFERENT CLINICAL TYPES OF ACUTE CORONARY SYNDROME
title_full_unstemmed	DYNAMICS OF CYTOKINE LEVELS IN THE HOSPITALIZED PATIENTS WITH DIFFERENT CLINICAL TYPES OF ACUTE CORONARY SYNDROME
title_sort	dynamics of cytokine levels in the hospitalized patients with different clinical types of acute coronary syndrome
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/9ff210b355834ee0a967fbcd61616b9b
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DYNAMICS OF CYTOKINE LEVELS IN THE HOSPITALIZED PATIENTS WITH DIFFERENT CLINICAL TYPES OF ACUTE CORONARY SYNDROME

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