Detection of Recent Myocardial Infarction Using Native T1 Mapping in a Swine Model: A Validation Study

Abstract Late gadolinium enhancement (LGE) imaging is the currently the gold standard for in-vivo detection of myocardial infarction. However, gadolinium contrast administration is contraindicated in patients with renal insufficiency. We aim to evaluate the diagnostic sensitivity and specificity of...

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Autores principales:	Chen Cui, Shuli Wang, Minjie Lu, Xuejing Duan, Hongyue Wang, Liujun Jia, Yue Tang, Arlene Sirajuddin, Sanjay K. Prasad, Peter Kellman, Andrew E. Arai, Shihua Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9ff281db452a47eb86493c0a2a6196d1
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spelling	oai:doaj.org-article:9ff281db452a47eb86493c0a2a6196d12021-12-02T16:08:14ZDetection of Recent Myocardial Infarction Using Native T1 Mapping in a Swine Model: A Validation Study10.1038/s41598-018-25693-12045-2322https://doaj.org/article/9ff281db452a47eb86493c0a2a6196d12018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25693-1https://doaj.org/toc/2045-2322Abstract Late gadolinium enhancement (LGE) imaging is the currently the gold standard for in-vivo detection of myocardial infarction. However, gadolinium contrast administration is contraindicated in patients with renal insufficiency. We aim to evaluate the diagnostic sensitivity and specificity of this contrast-free MRI technique, native T1 mapping, in detecting recent myocardial infarction versus a reference histological gold standard. Ten pigs underwent CMR at 2 weeks after induced MI. The infarct size and transmural extent of MI was calculated using native T1 maps and LGE images. Histological validation was performed using triphenyl tetrazolium chloride (TTC) staining in the corresponding ex-vivo slices. The infarct size and transmural extent of myocardial infarction assessed by T1 mapping correlated well with that assessed by LGE and TTC images. Using TTC staining as the reference, T1 mapping demonstrated underestimation of infarct size and transmural extent of infarction. Additionally, there was a slight but not significant difference found in the diagnostic performance between the native T1 maps and LGE images for the location of MI. Our study shows that native T1 mapping is feasible alternative method to the LGE technique for the assessment of the size, transmural extent, and location of MI in patients who cannot receive gadolinium contrast.Chen CuiShuli WangMinjie LuXuejing DuanHongyue WangLiujun JiaYue TangArlene SirajuddinSanjay K. PrasadPeter KellmanAndrew E. AraiShihua ZhaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chen Cui Shuli Wang Minjie Lu Xuejing Duan Hongyue Wang Liujun Jia Yue Tang Arlene Sirajuddin Sanjay K. Prasad Peter Kellman Andrew E. Arai Shihua Zhao Detection of Recent Myocardial Infarction Using Native T1 Mapping in a Swine Model: A Validation Study
description	Abstract Late gadolinium enhancement (LGE) imaging is the currently the gold standard for in-vivo detection of myocardial infarction. However, gadolinium contrast administration is contraindicated in patients with renal insufficiency. We aim to evaluate the diagnostic sensitivity and specificity of this contrast-free MRI technique, native T1 mapping, in detecting recent myocardial infarction versus a reference histological gold standard. Ten pigs underwent CMR at 2 weeks after induced MI. The infarct size and transmural extent of MI was calculated using native T1 maps and LGE images. Histological validation was performed using triphenyl tetrazolium chloride (TTC) staining in the corresponding ex-vivo slices. The infarct size and transmural extent of myocardial infarction assessed by T1 mapping correlated well with that assessed by LGE and TTC images. Using TTC staining as the reference, T1 mapping demonstrated underestimation of infarct size and transmural extent of infarction. Additionally, there was a slight but not significant difference found in the diagnostic performance between the native T1 maps and LGE images for the location of MI. Our study shows that native T1 mapping is feasible alternative method to the LGE technique for the assessment of the size, transmural extent, and location of MI in patients who cannot receive gadolinium contrast.
format	article
author	Chen Cui Shuli Wang Minjie Lu Xuejing Duan Hongyue Wang Liujun Jia Yue Tang Arlene Sirajuddin Sanjay K. Prasad Peter Kellman Andrew E. Arai Shihua Zhao
author_facet	Chen Cui Shuli Wang Minjie Lu Xuejing Duan Hongyue Wang Liujun Jia Yue Tang Arlene Sirajuddin Sanjay K. Prasad Peter Kellman Andrew E. Arai Shihua Zhao
author_sort	Chen Cui
title	Detection of Recent Myocardial Infarction Using Native T1 Mapping in a Swine Model: A Validation Study
title_short	Detection of Recent Myocardial Infarction Using Native T1 Mapping in a Swine Model: A Validation Study
title_full	Detection of Recent Myocardial Infarction Using Native T1 Mapping in a Swine Model: A Validation Study
title_fullStr	Detection of Recent Myocardial Infarction Using Native T1 Mapping in a Swine Model: A Validation Study
title_full_unstemmed	Detection of Recent Myocardial Infarction Using Native T1 Mapping in a Swine Model: A Validation Study
title_sort	detection of recent myocardial infarction using native t1 mapping in a swine model: a validation study
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9ff281db452a47eb86493c0a2a6196d1
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Detection of Recent Myocardial Infarction Using Native T1 Mapping in a Swine Model: A Validation Study

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