INI1-Intact Sinonasal Carcinoma with Rhabdoid Features

Sinonasal malignancies are known for their associated poor prognosis and diversity of histologic features. While poor prognosis is largely due to advanced disease at presentation, histologic features also play a significant role. Therefore, accurate pathologic diagnosis is of utmost importance. Here...

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Autores principales:	Erin Mulry, Danielle M. Blake, Poornima Hegde, Todd E. Falcone
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Otorhinolaryngology RF1-547
Acceso en línea:	https://doaj.org/article/9ff2de932d7746bd9b20a7903bee602b
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spelling	oai:doaj.org-article:9ff2de932d7746bd9b20a7903bee602b2021-11-29T00:57:01ZINI1-Intact Sinonasal Carcinoma with Rhabdoid Features2090-677310.1155/2021/6075130https://doaj.org/article/9ff2de932d7746bd9b20a7903bee602b2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/6075130https://doaj.org/toc/2090-6773Sinonasal malignancies are known for their associated poor prognosis and diversity of histologic features. While poor prognosis is largely due to advanced disease at presentation, histologic features also play a significant role. Therefore, accurate pathologic diagnosis is of utmost importance. Here, we describe a 63-year-old male with chronic left-sided nasal obstruction and left-sided epistaxis who was found to have a large mass occupying most of the nasal cavity extending through the nasopharynx to just below the nasopharyngeal surface of the soft palate. During surgical excision, the mass was noted to originate from the floor of the maxillary sinus with erosion of the medial wall of the maxillary sinus. Pathology revealed a diagnosis of INI1-intact poorly differentiated composite carcinoma with rhabdoid phenotype and sarcomatoid and squamous cell carcinoma foci arising within an inverted papilloma. Included in this report is a detailed description of both the patient’s medical course and this pathologically novel sinonasal neoplasm. We aim to elucidate this rare tumor’s complex features in order to improve future diagnosis and stimulate prospective research on sinonasal malignancies with complex histology.Erin MulryDanielle M. BlakePoornima HegdeTodd E. FalconeHindawi LimitedarticleOtorhinolaryngologyRF1-547ENCase Reports in Otolaryngology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Otorhinolaryngology RF1-547
spellingShingle	Otorhinolaryngology RF1-547 Erin Mulry Danielle M. Blake Poornima Hegde Todd E. Falcone INI1-Intact Sinonasal Carcinoma with Rhabdoid Features
description	Sinonasal malignancies are known for their associated poor prognosis and diversity of histologic features. While poor prognosis is largely due to advanced disease at presentation, histologic features also play a significant role. Therefore, accurate pathologic diagnosis is of utmost importance. Here, we describe a 63-year-old male with chronic left-sided nasal obstruction and left-sided epistaxis who was found to have a large mass occupying most of the nasal cavity extending through the nasopharynx to just below the nasopharyngeal surface of the soft palate. During surgical excision, the mass was noted to originate from the floor of the maxillary sinus with erosion of the medial wall of the maxillary sinus. Pathology revealed a diagnosis of INI1-intact poorly differentiated composite carcinoma with rhabdoid phenotype and sarcomatoid and squamous cell carcinoma foci arising within an inverted papilloma. Included in this report is a detailed description of both the patient’s medical course and this pathologically novel sinonasal neoplasm. We aim to elucidate this rare tumor’s complex features in order to improve future diagnosis and stimulate prospective research on sinonasal malignancies with complex histology.
format	article
author	Erin Mulry Danielle M. Blake Poornima Hegde Todd E. Falcone
author_facet	Erin Mulry Danielle M. Blake Poornima Hegde Todd E. Falcone
author_sort	Erin Mulry
title	INI1-Intact Sinonasal Carcinoma with Rhabdoid Features
title_short	INI1-Intact Sinonasal Carcinoma with Rhabdoid Features
title_full	INI1-Intact Sinonasal Carcinoma with Rhabdoid Features
title_fullStr	INI1-Intact Sinonasal Carcinoma with Rhabdoid Features
title_full_unstemmed	INI1-Intact Sinonasal Carcinoma with Rhabdoid Features
title_sort	ini1-intact sinonasal carcinoma with rhabdoid features
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/9ff2de932d7746bd9b20a7903bee602b
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INI1-Intact Sinonasal Carcinoma with Rhabdoid Features

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