Comparisons of microvascular and macrovascular changes in aldosteronism-related hypertension and essential hypertension

Abstract Case-control observational study to evaluate the microvascular and macrovascular changes in patients with hypertension secondary to primary aldosteronism (PA), essential hypertension (EH) and healthy subjects. Measurements of arterial stiffness including augmentation index (AIx) and pulse w...

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Autores principales:	Monica Varano, Pierluigi Iacono, Massimiliano M. Tedeschi, Claudio Letizia, Mario Curione, Claudio Savoriti, Erika Baiocco, Laura Zinnamosca, Cristiano Marinelli, Barbara Boccassini, Mariacristina Parravano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9ff4a7eec43f4a788575bc7b74fe07fb
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spelling	oai:doaj.org-article:9ff4a7eec43f4a788575bc7b74fe07fb2021-12-02T15:04:55ZComparisons of microvascular and macrovascular changes in aldosteronism-related hypertension and essential hypertension10.1038/s41598-017-02622-22045-2322https://doaj.org/article/9ff4a7eec43f4a788575bc7b74fe07fb2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02622-2https://doaj.org/toc/2045-2322Abstract Case-control observational study to evaluate the microvascular and macrovascular changes in patients with hypertension secondary to primary aldosteronism (PA), essential hypertension (EH) and healthy subjects. Measurements of arterial stiffness including augmentation index (AIx) and pulse wave velocity (PWV) were assessed using a TensioClinic arteriograph system. Retinal microcirculation was imaged by a Retinal Vessel Analyzer (RVA) and a non-midriatic camera (Topcon-TRC-NV2000). IMEDOS software analyzed the retinal artery diameter (RAD), retinal vein diameters (RVD) and arteriole-to-venule ratio (AVR) of the vessels coming off the optic disc. Thirty, 39 and 35 patients were included in the PA, EH and control group, respectively. The PA group showed higher PWV values compared only with the control group. The mean brachial and aortic AIx values did not show significant difference between groups. In the PA group, the mean RVD and AVR values were significantly lower than in the EH and control groups, whereas the parameters did not differ between the EH and control groups. In conclusion, AVR appears significantly modified in the PA group compared with the EH group and could represent an early and more reliable indicator of microvascular remodeling.Monica VaranoPierluigi IaconoMassimiliano M. TedeschiClaudio LetiziaMario CurioneClaudio SavoritiErika BaioccoLaura ZinnamoscaCristiano MarinelliBarbara BoccassiniMariacristina ParravanoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Monica Varano Pierluigi Iacono Massimiliano M. Tedeschi Claudio Letizia Mario Curione Claudio Savoriti Erika Baiocco Laura Zinnamosca Cristiano Marinelli Barbara Boccassini Mariacristina Parravano Comparisons of microvascular and macrovascular changes in aldosteronism-related hypertension and essential hypertension
description	Abstract Case-control observational study to evaluate the microvascular and macrovascular changes in patients with hypertension secondary to primary aldosteronism (PA), essential hypertension (EH) and healthy subjects. Measurements of arterial stiffness including augmentation index (AIx) and pulse wave velocity (PWV) were assessed using a TensioClinic arteriograph system. Retinal microcirculation was imaged by a Retinal Vessel Analyzer (RVA) and a non-midriatic camera (Topcon-TRC-NV2000). IMEDOS software analyzed the retinal artery diameter (RAD), retinal vein diameters (RVD) and arteriole-to-venule ratio (AVR) of the vessels coming off the optic disc. Thirty, 39 and 35 patients were included in the PA, EH and control group, respectively. The PA group showed higher PWV values compared only with the control group. The mean brachial and aortic AIx values did not show significant difference between groups. In the PA group, the mean RVD and AVR values were significantly lower than in the EH and control groups, whereas the parameters did not differ between the EH and control groups. In conclusion, AVR appears significantly modified in the PA group compared with the EH group and could represent an early and more reliable indicator of microvascular remodeling.
format	article
author	Monica Varano Pierluigi Iacono Massimiliano M. Tedeschi Claudio Letizia Mario Curione Claudio Savoriti Erika Baiocco Laura Zinnamosca Cristiano Marinelli Barbara Boccassini Mariacristina Parravano
author_facet	Monica Varano Pierluigi Iacono Massimiliano M. Tedeschi Claudio Letizia Mario Curione Claudio Savoriti Erika Baiocco Laura Zinnamosca Cristiano Marinelli Barbara Boccassini Mariacristina Parravano
author_sort	Monica Varano
title	Comparisons of microvascular and macrovascular changes in aldosteronism-related hypertension and essential hypertension
title_short	Comparisons of microvascular and macrovascular changes in aldosteronism-related hypertension and essential hypertension
title_full	Comparisons of microvascular and macrovascular changes in aldosteronism-related hypertension and essential hypertension
title_fullStr	Comparisons of microvascular and macrovascular changes in aldosteronism-related hypertension and essential hypertension
title_full_unstemmed	Comparisons of microvascular and macrovascular changes in aldosteronism-related hypertension and essential hypertension
title_sort	comparisons of microvascular and macrovascular changes in aldosteronism-related hypertension and essential hypertension
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9ff4a7eec43f4a788575bc7b74fe07fb
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Comparisons of microvascular and macrovascular changes in aldosteronism-related hypertension and essential hypertension

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